Navegação por Revista "Ecotoxicology and Environmental Contamination"

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  • IPEN-DOC 23178

    MARTINI, G.A. ; ROGERO, S.O. ; ROGERO, J.R. . Cytotoxic effects caused by N,N-diethyl-meta-toluamide and radiation in Perna perna mussels. Ecotoxicology and Environmental Contamination, v. 12, n. 1, p. 33-37, 2017. DOI: 10.5132/eec.2017.01.05

    Abstract: The aim of this study was to evaluate the biological effects of ionizing radiation in combination with DEET on marine aquatic biota. It was studied the exposure of irradiated and non-irradiated marine mussels to different concentrations of DEET. It was compared the recoverability of mussels which were exposed to DEET after suffering another stressful action by the ionizing radiation. The cytotoxicity by the neutral red retention time assay was used to verify the DEET effect on the lysosomal membrane of Perna perna mussels hemocytes in non-irradiated and irradiated organisms. The organisms were irradiated at 3, 11 and 107 Gy doses of 60Co gamma rays and exposed to 0.1; 1.0 and 20.0 μg L-1 DEET. The results were obtained 24, 48 and 72h after irradiation. It was observed statistic significance at concentrations of 1.0 and 20.0 μg L-1 in non-irradiated mussels for all exposure times. In mussels irradiated with 3 Gy and 11 Gy it was observed that the retention time was not significantly different from trials in which the organisms were not irradiated. The 107 Gy dose caused some adverse effects to organisms showing a significant reduction in the number of cells compared with the other doses. The present study showed cytotoxic effect of DEET to Perna perna mussels at concentrations above 0.1 μg L-1 a value very close to the concentrations identified in the environment suggesting attention to this concentration range.


  • IPEN-DOC 22774

    SOUZA, A. ; MORENO, B.B.; ALMEIDA, J.E.; ROGERO, S.O. ; PEREIRA, C.D.S.; ROGERO, J.R. . Cytotoxicity evaluation of Amoxicillin and Potassium Clavulanate in Perna perna mussels. Ecotoxicology and Environmental Contamination, v. 11, n. 1, p. 21-26, 2016. DOI: 10.5132/eec.2016.01.04

    Abstract: Pharmaceutical compounds are identified in environmental matrices in the order of magnitude of ng L-1 to μg L-1. Among the drugs, antibiotics have been receiving special attention due to the problems caused to aquatic biota. The aim of this study was to evaluate the cytotoxicity of Amoxicillin and Potassium Clavulanate, in isolated and associated forms, to marine mussels Perna perna through neutral red retention time assay (NRRT), which assesses the stability of lisossomal membrane of test-organisms hemocytes. Amoxicillin caused cytotoxicity to the mussels in concentrations of OEC= 1 ng L-1, IC25-24h= 0.44 ng L-1, IC25-48h= 1.19 ng L-1 and IC25-72h= 0.85 ng L-1, Potassium Clavulanate was cytotoxic at concentrations of OEC= 10 ngL-1 in 24h; 50 ng L-1 and 100 ng L-1 at 48h and 72h. The inhibitory concentration values (IC25) were: 3.11 ng L-1, 3.45 ng L-1 and 3.43 ng L-1 at 24h, 48h and 72h respectively. In the test conducted with the combination of drugs, all concentrations were cytotoxic to mussels in 48h. In 72h only 40 ng L-1 Amoxicillin + 10 ng L-1 Potassium Clavulanate and 200 ng L-1 Amoxicillin + 50 ng L-1 Potassium Clavulanate were cytotoxic. The IC25 for Amoxicillin was 1.67 ng L-1 in 48h and 1.36 ng L-1 in 72h. For Potassium Clavulanate was 0.42 ng L-1 in 48h and in 72h was 0.34 ng L-1.

    Palavras-Chave: toxicity; antibiotics; mussels; animals; amines; indicators; pyrazines; drugs; pollutants


  • IPEN-DOC 26658

    BOIANI, N.F. ; SILVA, V.H.O.; GARCIA, V.S.G. ; DEL SOLE, S.V. ; BORRELY, S.I. . Electron beam irradiation of pharmaceuticals aiming at toxicity reduction: a binary mixture of fluoxetine and propranolol. Ecotoxicology and Environmental Contamination, v. 14, n. 1, p. 53-58, 2019. DOI: 10.5132/eec.2019.01.06

    Abstract: Significant evidence is available in the literature justifying the search for treatment technologies or process combinations to improve the decomposition of dozens of pharmaceuticals in wastewater. Conventional processing techniques are insufficient in removal of the pharmaceuticals, for having resistant waste and low biodegradability. Electron beam irradiation (EBI) may play an important role in this context, and relatively low doses have been reported for such purposes. The objective of this study was to apply the process of irradiation with electron beam in order to reduce the toxic effects of fluoxetine, propranolol, and a binary mixture of these pharmaceuticals in aqueous solution. Ecotoxicological tests conducted in two model organisms, Daphnia similis microcrustacean, and Vibrio fischeri bacterium. It was observed that D. similis was more sensitive to the pharmaceuticals and binary mixture, when compared to V. fischeri. When EBI was applied, all doses showed significant reduction of toxicity for D. similis, and the opposite for V. fischeri, when only 5.0 kGy showed a significant reduced of toxicity for the pharmaceuticals and binary mixture. 5.0 kGy was the best removal efficiency for toxicity, approximately 80% for D. similis and 20% for V. fischeri.

    Palavras-Chave: electron beams; irradiation; waste water; drugs; pollutants; pollution sources; removal; water treatment; chemical analysis; toxic materials; daphnia; bacteria; aquatic organisms


  • IPEN-DOC 24466

    CAVALCANTE, A.K. ; LOPES-FERREIRA, M.; ROGERO, S.O. ; ROGERO, J.R. . Evaluation of resveratrol toxicity in the embryolarval stage of Danio rerio fish. Ecotoxicology and Environmental Contamination, v. 12, n. 01, p. 133-139, 2017. DOI: 10.5132/eec.2017.01.15

    Abstract: Human beings concern about healthy life has driven researchers to study new compounds capable of reaching that desire. Resveratrol (3, 4 ‘, 5-trihydroxystilbene) a phenolic compound, is one of these substances which presents a variety of pharmacological actions, as antioxidant potential, anti-inflammatory capacity, protection against heart and cancer diseases. Despite the resveratrol health benefits studies, there is a little evidence of its toxicity in the literature in aquatic organisms, and especially the data on the concentration of resveratrol in the environment, making the present study fundamental for information about resveratrol ecotoxicity in the aquatic system. The aim of this study was to evaluate the toxicity of resveratrol in embryos and larvae of Danio rerio (zebrafish). The in vitro cytotoxicity and ecotoxicity assays were performed. The IC50 obtained in the NCTC-L929 cell line cytotoxicity assay was 38.5 mg L-1. The LC50 (96h) obtained in fish embryo toxicity test was 75.3 mg L-1 and the mean value of resveratrol LC50 (168h) obtained in the short-term chronic ecotoxicity assays performed with zebrafish larvae was 51.4 mg L-1. This work provided data on the toxicity of resveratrol in the embryonic stage of fish of the species Danio rerio and the toxic effects are dependent on its concentration.


  • IPEN-DOC 19561

    MOREIRA, E.G. ; MATHOR, M.B. ; VASCONCELLOS, M.B.A. . Gamma ray sterilization study on a Perna perna mussel reference material. Ecotoxicology and Environmental Contamination, v. 8, n. 1, p. 149-152, 2013.

    Palavras-Chave: calibration standards; mussels; sterilization; gamma radiation


  • IPEN-DOC 25728

    DAMASCENO, K.C. ; CAVALCANTE, A.K. ; MAZIERO, J.S. ; MARTINI, G.A. ; ORMENIO, M.B. ; MAMEDE, F.C. ; MIRANDA, C.S. ; CAMPELLO, F.A. ; IZIDORO, J.C. ; ROGERO, S.O. ; FUNGARO, D.A. ; LOPES-FERREIRA, M.; ROGERO, J.R. . In vitro and in vivo toxicity of coal fly Ash Lechatee. Ecotoxicology and Environmental Contamination, v. 13, n. 1, p. 73-78, 2018. DOI: 10.5132/eec.2018.01.08

    Abstract: Coal Fly ash is a major solid waste from coal-fired power stations. In Brazil, more than 4 million tons per year of fly ash are generated and only 30% is applied as raw material for cement and concrete production. The remaining is disposed in on-site ponds, nearby abandoned or active mine sites and landfills. The inadequate disposal of fly ash may pose a significant risk to the environment due to the possible leaching of hazardous pollutants into the surrounding soil and groundwater. A combination of leaching tests, cytotoxicity and ecotoxicological assays were used in this studyin order toevaluate the possible adverse effects of coal fl y ash in non-target organisms. The sample was collected from coal-fi red power plant located in Southern Brazil and the coal fly ash was submitted to a leaching procedure using USEPA SW 864 Method 1311. The leachate was prepared in six dilutions: 1.56%, 3.12%, 6.25%, 12.5%, 25% and 50%. Acute toxicity tests were performed on NCTC clone 929 (CCIAL-020) culture cells by neutral red uptake cytotoxicity method; acute ecotoxicity usingDaphnia similisand Danio rerio embryos according to ABNT NBR 12713 and OECD 236, respectively were employed. The cytotoxicity index (CI50) obtained was 33%; the EC50of D. similis after 48 h of exposure to the leachate was 7.25% and the LC50of D. rerio after 96 h of exposure was 4.39%. The results of these bioassays indicated toxicity of the coal fly ash leachate toward exposed organisms.

    Palavras-Chave: coal; fly ash; ecology; toxicity; combustion products; waste disposal; water pollution; fishes; elutriation; environmental impacts; aquatic organisms; acute exposure; leachates; ore composition


  • IPEN-DOC 25068

    BORRELY, S.I. ; GARCIA, V.S.G. ; BORRELY, T.; FAVARO, D.I.T. . Metals, trace elements and ecotoxicity in sediments of the Cubatão River, Brazil. Ecotoxicology and Environmental Contamination, v. 13, n. 2, p. 49-61, 2018. DOI: 10.5132/eec.2018.02.07

    Abstract: The Cubatão River is one of the most important waterways of the coast of São Paulo. The continuous discharge of domestic and industrial effluents into the river and its tributaries resulted in loss of water quality across the system. Industrial and domestic landfills are also located around the studied area. The purpose of this study was to assess two aspects of sediments from the river and two of its tributaries (Perequê and Pilões Rivers): presence of trace elements and toxic metals, and ecotoxicity. Four sampling surveys were conducted from 2010 to 2011 on six different sites (here named P0, P2, P4, P5, P7 and P8). Ecotoxicity was assessed by exposing Hyalella azteca to the collected sediments. Instrumental Neutron Activation Analysis (INAA) and Atomic Absorption Spectrometry (GF AAS and CV AAS) techniques were applied for measuring concentration of metals and trace elements. The latter enabled quantification of Cd, Pb and Hg, while the former enabled quantification of a wide range of metals and trace elements. As, Cr and Zn concentrations obtained by INAA as well as AAS results were compared to threshold effect levels (TEL) and probable effect levels (PEL), the sediment quality guidelines proposed by the Canadian Council of Ministers of the Environment (CCME) for evaluating the potential effects on aquatic organisms. Cd and Hg values did not exceed TEL at the most of samples. Pb exceeded TEL at only one site campaign. As, Cr and Zn values exceeded TEL in most of sampling sites, with P2 and P4 showing the highest concentrations. Enrichment Factor (EF) and Geoaccumulation Index (IGeo) were calculated for the elements determined by INAA using North American Shale Composite (NASC) and regional background values. In short, As, Br, Cr, Hf, Pb, Sb and Zn were the elements found in concerning amounts, especially As, Br, Cr and Zn. Toxicity results revealed toxic effects on sediments from P2 and P5 (mortality > 50%). Body size analysis demonstrated negative effects at P4 (length smaller than 2,500.00 μm). Data crossing analyses indicate As and Br as main possible contributors to high toxicity levels.


A pesquisa no RD utiliza os recursos de busca da maioria das bases de dados. No entanto algumas dicas podem auxiliar para obter um resultado mais pertinente.

É possível efetuar a busca de um autor ou um termo em todo o RD, por meio do Buscar no Repositório , isto é, o termo solicitado será localizado em qualquer campo do RD. No entanto esse tipo de pesquisa não é recomendada a não ser que se deseje um resultado amplo e generalizado.

A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em Navegar

Os filtros disponíveis em Navegar tais como: Coleções, Ano de publicação, Títulos, Assuntos, Autores, Revista, Tipo de publicação são autoexplicativos. O filtro, Autores IPEN apresenta uma relação com os autores vinculados ao IPEN; o ID Autor IPEN diz respeito ao número único de identificação de cada autor constante no RD e sob o qual estão agrupados todos os seus trabalhos independente das variáveis do seu nome; Tipo de acesso diz respeito à acessibilidade do documento, isto é , sujeito as leis de direitos autorais, ID RT apresenta a relação dos relatórios técnicos, restritos para consulta das comunidades indicadas.

A opção Busca avançada utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.


Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.

Autor: Maprelian

Título: loss of coolant

Tipo de publicação: Texto completo de evento

Ano de publicação: 2015

Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da International Atomic Energy Agency – IAEA , por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.

95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN, .

Ao efetuar a busca por um autor o RD apresentará uma relação de todos os trabalhos depositados no RD. No lado direito da tela são apresentados os coautores com o número de trabalhos produzidos em conjunto bem como os assuntos abordados e os respectivos anos de publicação agrupados.

O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.

Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.

Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).



O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.

2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.