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BibliotecaTerezine Arantes Ferraz

Navegação por Agências de fomento "Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)"

Navegação por Agências de fomento "Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)"

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  • IPEN-DOC 23152

    BERECZKI, ALLAN ; WETTER, NIKLAUS U. . 100W continuous linearly polarized, high beam quality output from standard side-pumped Nd:YAG laser modules. Optics and Laser Technology, v. 96, p. 271-275, 2017. DOI: 10.1016/j.optlastec.2017.05.020

    Abstract: Dynamically stable operation with joined stability zones of a linearly polarized resonator is shown for a laser containing two diode side-pumped Nd:YAG rods. The unpolarized resonator generated 115W of output. When polarized by a Brewster plate, it reached 100.5W of output power at a beam quality M2 < 2. Best measured beam quality was of 1.1 and 1.3 in the x and y directions respectively, with 76W of 95% polarized output. The output power achieved is, to our knowledge, the highest reported for continuous polarized, fundamental-mode lasers using standard side-pumped Nd:YAG modules.


  • IPEN-DOC 26856

    BOAS, CRISTIAN W.V. ; SILVA, JEFFERSON de J. ; BENEDETTO, RAQUEL ; MENGATTI, JAIR ; ARAUJO, ELAINE B. de . 177Lu-PSMA-617: Brazilian experience. Journal of Nuclear Medicine, v. 60, supplement 1 200, 2019.

    Abstract: Introduction: PSMA-617 radiolabeled with lutetium-177 has shown good results in compassionate studies around the world, and there is great interest in this kind of therapy in Brazil. The Nuclear and Research Institute (IPEN-CNEN) in São Paulo city, is a national radiopharmaceutical producer and the distribution of radiopharmaceuticals for therapy in a country of continental dimensions such as Brazil, becomes a challenge from the standpoint of guaranteeing the stability of the product. This work evaluated the scheduling of pilot batches for the production of 177Lu-PSMA-617 and studied the effect of dilution and freezing on the stability of mono-doses of the product. Materials and Methods: Radiolabeling of PSMA-617 (ABX, Germany) with lutetium-177 (JSC, Russia) was performed in heating block at 90 °C for 30 minutes, 37 GBq (1 Ci), 500 μg of peptide and sodium ascorbate (0,5 M pH 4,7) as buffer. At the end of the radiolabel, 0,5 mL of DTPA solution (4 mg/mL pH 4,5) was added and the product was diluted with an appropriate volume of saline solution 0,9%. The final product was filtrated in 0.22 membrane and the doses were fractionated (7,4 GBq calibrated for 24 hours in approximately 2,4 mL) and conditioned in appropriate lead chambers inside a dry ice bucket for transport simulation. The radiochemical purity (RP) was evaluated in a stability study at, 24 and 48 hours by TLC and HPLC. The radionuclidic purity, sterility and bacterial endotoxins were also evaluated. Results and discussion: The radiopharmaceutical was stable after 48 hours (99.47% TLC and 99.39% HPLC), and was approved in radionuclidic, sterility and endotoxins assays. The vials fractionated in mono-doses calibrated for 24 hours showed high stability through freezing and dilution, which allowed the transportation to the Cancer Hospital of Barretos, distant 420 km from the production center in São Paulo. All these mono-doses were administrated to the patients after 24 hours of the production. Also, these results denote that is possible to scale up this production until 74 GBq and be used in a clinical trial that is being planned. Conclusions: These carried out experiments demonstrated that it is possible to produce 177Lu-PSMA-617 for use in clinical trials in Brazil. Until now, four patients are under treatment (compassionate use). Also, these results demonstrate that it is still possible to increase production activity to 74 GBq, just like is normally done with 177Lu-DOTATATE.

    Palavras-Chave: lutetium 177; radiopharmaceuticals; prostate; neoplasms; brazil


  • IPEN-DOC 24704

    ARAGAO, LUIZ E.O.C.; ANDERSON, LIANA O.; FONSECA, MARISA G.; ROSAN, THAIS M.; VEDOVATO, LAURA B.; WAGNER, FABIEN H.; SILVA, CAMILA V.J.; SILVA JUNIOR, CELSO H.L.; ARAI, EGIDIO; AGUIAR, ANA P.; BARLOW, JOS; BERENGUER, ERIKA; DEETER, MERRITT N.; DOMINGUES, LUCAS G. ; GATTI, LUCIANA ; GLOOR, MANUEL; MALHI, YADVINDER; MARENGO, JOSE A.; MILLER, JOHN B.; PHILLIPS, OLIVER L.; SAATCHI, SASSAN. 21st Century drought-related fires counteract the decline of Amazon deforestation carbon emissions. Nature Communications, v. 9, n. 536, 2018. DOI: 10.1038/s41467-017-02771-y

    Abstract: Tropical carbon emissions are largely derived from direct forest clearing processes. Yet, emissions from drought-induced forest fires are, usually, not included in national-level carbon emission inventories. Here we examine Brazilian Amazon drought impacts on fire incidence and associated forest fire carbon emissions over the period 2003-2015. We show that despite a 76% decline in deforestation rates over the past 13 years, fire incidence increased by 36% during the 2015 drought compared to the preceding 12 years. The 2015 drought had the largest ever ratio of active fire counts to deforestation, with active fires occurring over an area of 799,293 km(2). Gross emissions from forest fires (989 +/- 504 Tg CO2 year(-1)) alone are more than half as great as those from old-growth forest deforestation during drought years. We conclude that carbon emission inventories intended for accounting and developing policies need to take account of substantial forest fire emissions not associated to the deforestation process.

    Palavras-Chave: carbon dioxide; deforestation; forests; monitoring; greenhouse gases; tropical regions; climates; droughts; fires; amazon river; brazil


  • IPEN-DOC 19230

    VIANA, R.S.; AGASTHYA, G.A.; YORIYAZ, H. ; KAPADIA, A.J.. 3D element imaging using NSECT for the detection of renal cancer: a simulation study in MCNP. Physics in Medicine and Biology, v. 58, n. 17, p. 5867-5883, 2013.

    Palavras-Chave: kidneys; carcinomas; computerized tomography; three-dimensional calculations; neutron emission; stimulated emission; simulation; m codes


  • IPEN-DOC 26646

    SILVA, J.P.L. ; TEIXEIRA, L.F. ; BELLINI, M.H. . [6]-Gingerol decreases clonogenicity and radioresistance of human prostate cancer cells. Clinical Oncology and Research, v. 2, n. 5, p. 1-3, 2019. DOI: 10.31487/j.COR.2019.05.07

    Abstract: The phenolic compound [6]-Gingerol, isolated from Zingiber officinale, has been demonstrated to have antitumor activity for different types of malignant tumours. Prostate cancer is the most common malignancy among males worldwide, being the second leading cause of cancer death in men. In the present study, we investigated the antitumor action of [6]-Gingerol on a human prostate cancer cell line (LNCaP). Our data shows that [6]-Gingerol treatment induced a dose-dependent decrease in the cell viability. Compared with the vehicle control, the cell viabilities were 79.90 ± 3.56% and 53.06 ± 7.82% when the LNCaP cells were exposed to 150 μg/mL and 300 μg/mL of [6]-Gingerol, respectively. The treatment of LNCaP with 300 μM of [6]-Gingerol led to a significant reduction (~25%) on the clonogenic survival of these cells. Furthermore, [6]-gingerol acted as a radiosensitizer for LNCaP cells. The pretreatment of these cells with [6]-Gingerol significantly enhanced the killing effects of ionizing radiation with a dose enhancement ratio of 1.25. Our results demonstrate the anti-tumour activities of [6]-Gingerol. Further studies are needed to elucidate the mechanisms involved.

    Palavras-Chave: prostate; neoplasms; radiosensitivity effects; radiosensitizers; radiosensitivity; clone cells; cloning; viability; medicinal plants; spices; radiotherapy; tumor cells


  • IPEN-DOC 25024

    VIEIRA, A.; SAMAD, R.E. ; VIEIRA JUNIOR, NILSON D. ; ROSSI, WAGNER de . Ablação a laser com pulsos ultracurtos do aço DIN 16MnCr5: um estudo do processo de furação / Laser ablation with ultrashort laser pulses in steel DIN 16 MnCr5: a study of drill process. In: CONGRESSO BRASILEIRO DE ENGENHARIA DE FABRICACAO, 9., 26-29 de junho, 2017, Joinville, SC. Anais... Rio de Janeiro, RJ: Associação Brasileira de Engenharia e Ciências Mecânicas, 2017.

    Abstract: A indústria automobilística tem como um de seus principais desafios, e consequentemente, foco de pesquisa, a redução do coeficiente de atrito entre alguns componentes e sistemas presentes nos automóveis. Um dos grandes benefícios dos avanços nesta área é o aumento da vida útil dos componentes e a melhor eficiência do motor. Desta maneira, uma das formas propostas pela tribologia para a redução de atrito é a texturização de superfícies por laser. Neste trabalho, foi abordada a interação de pulsos laser de femtossegundos com o aço DIN 16MnCr5, utilizado na indústria automotiva. Objetivou-se buscar os melhores parâmetros de processo para obter micro cavidades com pouca ou nenhuma zona afetada pelo calor e sem a presença de rebarbas e material ressolidificado, presentes na texturização com laser de pulsos longos (nanossegundos). Para a realização do estudo foi utilizada a técnica de escaneamento diagonal, D-Scan, para determinação dos limiares de ablação em função da sobreposição de pulsos. Também foram realizados estudos de formação das cavidades com a variação da posição do ponto focal e do perfil espacial do feixe laser. São apresentados resultados de análises obtidas por microscopia óptica e de varredura e interferometria de luz branca.


  • IPEN-DOC 24719

    CARVALHO, SABRINA G.M. ; MUCCILLO, ELIANA N.S. ; MUCCILLO, REGINALDO . AC electric field assisted pressureless sintering zirconia: 3mol% yttria solid electrolyte. Physica Status Solidi A: applications and materials science, v. 215, n. 6, p. 1700647-1 - 1700647-5, 2018. DOI: 10.1002/pssa.201700647

    Abstract: 3mol% yttria ionic conductors are sintered by applying AC electric fields with frequencies in the 0.5-1.0kHz range at 1100 degrees C. The sintering experiments are conducted in pressed pellets positioned between platinum electrodes inside a dilatometer furnace. The dilatometer is modified in order to allow for the simultaneous monitoring of thickness shrinkage, electric voltage, and current across the pellet. The results show that the higher the frequency of the electric field, the higher the attained shrinkage and the apparent density of the pellets. Increasing the frequency of the applied electric field leads to an increase in the Joule heating promoted by the electric current pulse through the polycrystalline ceramic sample. A higher frequency therefore leads to higher amount of thermal energy delivered to the sample, favoring enhanced densification. The ionic resistivity decreases in pellets sintered with increasing frequency of the applied electric field. We suggest that Joule heating favors pore elimination and the removal of chemical species at the space charge region, inhibiting the blocking of oxide ions at the interfaces.

    Palavras-Chave: ac systems; ceramics; dilatometry; electric fields; electric impedance; hz range; ionic conductivity; joule heating; pellets; polycrystals; porosity; shrinkage; sintered materials; sintering; density; solid electrolytes; temperature range 1000-4000 k; thickness; yttrium oxides; zirconium oxides


  • IPEN-DOC 18371

    AZEVEDO, JULIANA de S.; HORTELLANI, MARCOS A. ; SARKIS, JORGE E.S. . Accumulation and distribution of metals in the tissues of two catfish species from Cananéia and Santos - São Vicente Estuaries. Brazilian Journal of Oceanography, v. 60, n. 4, p. 463-472, 2012.

    Palavras-Chave: brazil; coastal waters; estuaries; contamination; metals; copper; zinc; cadmium; lead; fishes; animal tissues; biological accumulation


  • IPEN-DOC 06792

    SHIBUYA, ELISA K. . Acoplamento laser - espectrometro de massa de dupla focalizacao com fonte de plasma induzido (LA-HR-ICPMS): estudos fundamentais e analises quantitativa em amostras solidas. 1999. Dissertacao (Mestrado) - Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP, São Paulo. 159 p. Orientador: Jorge Eduardo Souza Sarkis.

    Palavras-Chave: ablation; icp mass spectroscopy; lasers; chemical analysis; glass; trace amounts; impurities; sample preparation; geologic surveys


  • IPEN-DOC 26619

    NANDENHA, J. ; NAGAHAMA, I.H.F. ; YAMASHITA, J.Y. ; FONTES, E.H. ; AYOUB, J.M.S. ; SOUZA, R.F.B. de ; FONSECA, F.C. ; NETO, A.O. . Activation of methane on PdZn/C electrocatalysts in an acidic electrolyte at low temperatures. International Journal of Electrochemical Science, v. 14, n. 12, p. 10819-10834, 2019. DOI: 10.20964/2019.12.76

    Abstract: PdZn/C electrocatalysts were prepared by sodium borohydride utilized as reducing agent for activation methane in an acidic medium at room temperature and in a proton exchange membrane fuel cell (PEMFC) at 80°C. The materials prepared were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). The diffractograms of the PdZn/C electrocatalysts showed only peaks associated with Pd face-centered cubic (fcc) structure. Cyclic voltammograms (CV) of all electrocatalysts after adsorption of methane shown an increment in current during the anodic scan, this effect was more pronounced for Pd(70)Zn(30)/C. In situ ATR-FTIR (Attenuated Total Reflectance-Fourier Transform Infrared) experiments was not observed the formation of intermediates adsorbed for PdZn/C electrocatalysts, this behavior indicated that the methane oxidation occurs by parallel mechanisms. Polarization curves at 80°C in PEMFC show that Pd(90)Zn(10)/C has superior performance over the other electrocatalysts in methane oxidation.

    Palavras-Chave: methane; palladium; zinc; electrocatalysts; sodium compounds; borohydrides; reduction; oxidation; polarization; electrolytes; diagrams


  • IPEN-DOC 26397

    QUEIROZ, CARLA M.S. ; MACHADO, ARTHUR P. ; PAIVA, ANA R.N. ; ANTONIASSI, RODOLFO M. ; VAZ, JORGE M. ; SPINACE, ESTEVAM V. . Active Pt/CeO2 catalysts prepared by an alcohol‑reduction process for low‑temperature CO‑PROX reaction. Materials for Renewable and Sustainable Energy, v. 8, n. 3, p. 1-8, 2019. DOI: 10.1007/s40243-019-0155-y

    Abstract: Pt/CeO2 catalysts were prepared with 0.5 and 1 wt% of Pt loadings by an alcohol-reduction process using a solution of ethylene glycol and water as a reducing agent and solvent. The obtained catalysts were characterized by energy-dispersive X-ray spectroscopy, X-ray diffraction, and transmission electron microscopy. Transmission electron micrographs showed Pt nanoparticles with average sizes of 2.2 and 2.4 nm for Pt content of 0.5 and 1 wt%, respectively. The preferential oxidation of carbon monoxide in hydrogen-rich stream (CO-PROX reaction) was studied in the temperature range of 25–150 °C. Pt/CeO2 catalysts showed maximum CO conversions in the range of 80–98% and CO2 selectivity in the range of 50–70% at 50 °C.

    Palavras-Chave: catalysts; cerium; cerium oxides; platinum; alcohols; reduction; hydrogen; carbon monoxide; selective catalytic reduction


  • IPEN-DOC 26398

    PAPAI, RODRIGO; FREITAS, MILLENA A.S. de; FONSECA, KARINA T. da; ALMEIDA, GILMAR A. de ; SILVEIRA, JOÃO R.F. da; SILVA, ANDRE L.N. da; FERREIRA NETO, JOÃO B.; SANTOS, CELIA A.L. dos; LANDGRAF, FERNANDO J.G.; LUZ, MACIEL S.. Additivity of optical emissions applied to neodymium and praseodymium quantification in metallic didymium and (Nd,Pr)-Fe-B alloy samples by low-resolution atomic emission spectrometry: an evaluation of the mathematical approach used to solve spectral interferences. Analytica Chimica Acta, v. 1085, p. 21-28, 2019. DOI: 10.1016/j.aca.2019.07.049

    Abstract: In this work, the effectiveness of a mathematical approach to solve the spectral interferences involved in the optical emission of two chemical species (neodymium and praseodymium) when using monochromators with low-resolution in atomic spectrometry is evaluated. Although recent technological advances have promoted spectrometers equipped with high-resolution monochromators, which have a great instrumental capability in the separation of nearby lines and consequently avoid spectral interferences, many laboratories still have old spectrometers installed with insufficient resolution to overcome such interferences. In order to evaluate a mathematical approach based on Lambert-Beer's Law, the optical emissions of neodymium and praseodymium were monitored on a low-resolution (200 pm) flame atomic emission spectrometry (F-AES). These two elements were strategically chosen as an application model because they exhibit similar physicochemical properties, joint occurrence in nature and because they are increasingly used in the manufacture of super-magnets, a material increasingly required by the high technology industry. The effectiveness of the mathematical approach was evaluated in three different ways: (i) by recovery of the analytes in synthetic mixtures containing known quantities of the species; (ii) by spike and recovery trials on a representative blend of dissolved samples and (iii) by comparing the results obtained with another analytical method: Inductively coupled plasma optical emission spectrometry (ICP-OES) with a higher spectral resolution. The results indicate the effectiveness of this simple mathematical approach, allow the “survival” of instruments equipped with low-resolution monochromators and demonstrate the applicability of this approach to spectral correction. In addition, this work contributes an analytical method for the quantification of neodymium and praseodymium in metallic alloy samples involved in the production of super-magnets, aiding in the strict quality control of these materials.

    Palavras-Chave: additives; emission; absorption spectroscopy; neodymium; praseodymium; spectra; interference; atoms


  • IPEN-DOC 12314

    BOTTA, SERGIO B.; ANA, PATRICIA A. da; ZEZELL, DENISE M. ; POWERS, JOHN M.; MATOS, ADRIANA B.. Adhesion after erbium, chromium: yttrium-scandium-gallium-garnet laser aplication at three different irradiation conditions. Lasers in Medical Science, v. 24, n. 1, p. 67-73, 2009.

    Palavras-Chave: erbium; chromium; yttrium; scandium; gallium; garnets; laser radiation; teeth; caries; tissues; cooling; water; bonding


  • IPEN-DOC 24839

    OSHIRO, MAURICIO T. ; SAKATA, SOLANGE K. ; POTIENS JUNIOR, ADEMAR J. . Adsorption isotherms for the removal of Am-241 in radioactive liquid wastes using magnetite nanoparticles. In: PAN AMERICAN CONGRESS OF NANOTECHNOLOGY, 1st, 27-30 de novembro, 2017, Guarujá, SP. Abstract... 2017.

    Abstract: Americium-241 (Am-241) is a radionuclide with half-life of 432 years, emitting alpha particles and low gamma energy and it is also considered radiotoxic. Am-241 is produced, in a low level, from nuclear fuel and laboratory wastes. Magnetite nanoparticles (Fe3O4) are iron oxides that possess highly magnetic properties, and its application for removal of water contaminants refers due to its high surface area which allows the adsorption capability and the facility to be prepared and removed from the aqueous medium. In This study, magnetite was synthesized by coprecipitation method largely described. Batch experiments were accomplished at room temperature, at pH 6 and the contacts varying from 2.5, 5, 10, 20, 30, 40, 50, 60 minutes and at 30 minutes for the isotherms experiments. The solid containing magnetite and Am-241 were removed with a magnet and the solution analyzed in a gamma-ray spectrometer (Canberra Model GX2518) which could be quantified. Results show that magnetite possess a capability of removal up to 80% of Am-241 at room temperature, indicating that magnetite nanoparticles are a good sorbent for the removal of radionuclides. Langmuir and Freundlich Isotherms models were investigated and the parameters obtained. Langmuir’s isotherm showed constants of KL (75.7575 L/mg), Q (0.1617 mg/g) and R2 (0.9892) and Freundlich’s isotherm exhibited values of KF (2.6416 [(mg/g).(L/mg)1/n]), 1/n (0.7853 mg/g) and R2 (0.8395), which indicates that the Am- 241 removal from magnetite fits more suitable the Langmuir isotherm model. The thermodynamics parameters, such as the enthalpy and entropy of adsorption, the activation energy, as well as, the kinetics studies are under development.


  • IPEN-DOC 24415

    SANTOS, SILAS C. ; RODRIGUES, ORLANDO ; CAMPOS, LETICIA L. . Advances in colloidal processing of rare earth particles. Current Smart Materials, v. 3, p. 1-18, 2018.

    Abstract: Abstract: Background: New insights into materials science provide development of smart nano/micro structured materials for advanced applications. Rare earth includes a set of chemical elements (from La to Lu, including Sc and Y) with unique properties, the use of which is evidenced by luminescence applications. Colloidal processing offers great possibilities to obtain smart materials by controlling inter-particle forces, as well as their evolution during ceramic processing. The present article reports a review on colloidal processing with emphasis on rare earth powders. A general view about rare earths properties, including scientific investigations and applications are also presented. Methods: General view on rare earth sources, classification, properties, studies, and applications are reported. Besides, a review on colloidal processing covering particle characteristics, inter- particle forces, dispersion methods, rheology of suspensions, shaping process, drying-sintering stage, and microstructure formation is reported. Results: Yttria is the most used rare earth oxide in phosphors applications (70%). Synthesis routes imply on powder properties. Particle characteristics as size, shape, density, and surface area are important parameters for colloidal processing. The control of inter- particle forces by zeta potential evaluation and using dispersion methods provide conditions to prepare stable suspensions. Consolidation of colloidal particles into a desired shape depends on both viscosity and rheological behavior of suspensions. Drying-sintering conditions are effective on microstructure formation and component characteristics. Bio-prototyping is a low cost method, which provides components with complex shape and cellular architecture. Conclusion: Rare earths exhibit remarkable properties, being applied in diverse technological end-use. Colloidal processing provides opportunities to form smart materials since synthesis of colloids until development of complex ceramic components by shaping methods and thermal treatment. Even though colloidal processing is quite mature, investigations on rare earths involving inter- particle forces, shaping, drying-sintering stage, and microstructure formation are very scarce.

    Palavras-Chave: rare earths; processing; dispersions; particles; rheology; sintering; colloids


  • IPEN-DOC 26077

    ANA, PATRICIA A.; PEREIRA, DAISA de L. ; FERREIRA, ELIZABETE dos S.; FIGUEREDO, DANIELA C.; DAGUANO, JULIANA K.F.B.; ZEZELL, DENISE M. . Advances in the prevention and monitoring of root dentin demineralization using lasers. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: The increase in the life expectancy and the longer permanence of the teeth in the oral cavity also led to an augment in the prevalence of root caries lesions. These lesions require more attention because of their rapid progression and difficulty in early diagnosis and monitoring. In this context, the irradiation of the tissues with high intensity lasers has been shown as an important way for preventing lesion formation because lasers chemically modify the irradiated dental hard tissues and make them more resistant to acid challenge. In addition, the association with ceramic biomaterials may allow additional remineralizing results. Together with therapeutics, the effective early diagnosis of incipient lesions is indispensable. Techniques that use lasers, such as optical coherence tomography, have also been promising in this aspect because they allow the early diagnosis and monitoring of demineralizations with high resolution and in a non-detrimental way. This article aims to show the actions of high intensity laser therapies when associated or not with biomaterials, on the prevention and remineralization of root caries lesions, as well as the effectiveness of optical coherence tomography in the diagnosis and monitoring the effects of the treatments in these lesions.


  • IPEN-DOC 26975

    SANTIAGO, ELISABETE I. ; MATOS, BRUNO R. ; DRESCH, MAURO A.; ISIDORO, ROBERTA A. ; FONSECA, FABIO C. . Advances on Nafion-based composites for high temperature proton exchange membrane fuel cells. In: BRAZIL MRS MEETING, 16th, September 10-14, 2017, Gramado, RS. Abstract... São Carlos, SP: Aptor Software, 2017. p. 55-55.

    Abstract: PEMFC (Proton exchange membrane fuel cell) is considered a promising and efficient hydrogen fuelled electrical power source. However, PEMFC faces several technical problems, such as sluggish electrode reaction kinetics involving the limiting rate of the oxygen reduction and alcohol oxidation reactions, and high resistance to ion transport that could be surpassed with increasing of the operation temperature. The main impediment for such a temperature increase is the water dependent performance of the state-of-the-art Nafion electrolyte. Above 80 ºC water starts to evaporate considerably and Nafion microdomains begin to shrink, disrupting its percolative structure, leading from a conductor to insulator transition. In this work, the incorporation in-situ or ex-situ of an inorganic phase with hydrophilic properties, such as TiO2 and SiO2, into Nafion membranes has been evaluated as an interesting alternative to produce stable electrolytes able to operate at higher temperatures (130o C). The physical-chemistry and electrochemical characterisation has shown that the inorganic particles located in both the nonionic and ionic regions of the ionomer have important contributions to enhanced thermal stability and water uptake. Such features resulted in significant improvements of the PEMFCs using composite electrolytes tested at high operating temperature and low relative humidity. In addition, remarkable enhancement on the DEFC (Direct Ethanol Fuel Cell) performance (122 mW cm‑2) has been obtained as a result of an increase of ethanol oxidation reaction rate promoted by the combination of enhanced catalyst activity and high temperature of operation using stable composite Nafion-SiO2 electrolytes.


  • IPEN-DOC 09985

    PEREIRA, ANDREA A. . Alteracoes quimicas e fisicas de tecidos duros irradiados por laser de neodimio chaveado. 2003. Tese (Doutoramento) - Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP, Sao Paulo. 127 p. Orientador: Denise Maria Zezell. Coorientador: Wagner de Rossi.

    Palavras-Chave: dentistry; lasers; teeth; enamels; neodymium lasers; biological effects; animal tissues; biological materials; lasers; chemical analysis


  • IPEN-DOC 23325

    SILVA, LEANDRO G. da ; SAMAD, RICARDO E. ; VIEIRA JUNIOR, NILSON D. ; ROSSI, WAGNER de . Alteração da cor no aço ASTM F138 por meio de irradiação com laser de femtossegundo / Color change in metals by means of regular nanostructures produced by femtosecond laser pulses. In: ABM WEEK; CONGRESSO ANUAL DA ABM, 71.; ENCONTRO NACIONAL DE ESTUDANTES DE ENGENHARIA METALURGICA, DE MATERIAIS E DE MINAS, 16., 26-30 de setembro, 2016, Rio de Janeiro, RJ. Anais... São Paulo: Associação Brasileira de Metalurgia, Materiais e Mineração, 2016. p. 128-134.

    Abstract: Neste trabalho, foram estudados os efeitos da irradiação de uma superfície polida do aço inoxidável tipo ASTM F138 com laser de pulsos ultracurtos. As irradiações foram realizadas variando-se a velocidade de varredura do laser, ou seja, a taxa de sobreposição espacial de pulsos. Foi observado que após a irradiação houve uma visível mudança na coloração da amostra. Também foi verificado que com o aumento da taxa de sobreposição de pulsos a superfície tendeu a tornar-se preta, ou seja, absorvedora de luz. Com essa técnica, pode-se realizar marcações com alto contraste sem que haja formação de camadas de óxidos, nitretos ou alterações microestruturais no metal, o que é importante para um material com a precisão que um implante exige.


  • IPEN-DOC 27075

    SANTOS, G.L.; SANTUCCI, G.; OLIVEIRA-SILVA, T.; PRATES, R.A.; RIBEIRO, M.S. ; KATO, I.T.. Alteração da susceptibilidade de C. albicans resistente ao fluconazol após terapia fotodinâmica. In: VIEIRA NETO, HUGO (Ed.); SOARES, ALCIMAR B. (Ed.); FÉLIX, RODRIGO P.B. da C. (Ed.); VIEIRA NETO, HUGO (Org.); MAIA, JOAQUIM M. (Org.); PICHORIM, SÉRGIO F. (Org.); GAMBA, HUMBERTO R. (Org.); COSTA, EDUARDO T. (Org.) CONGRESSO BRASILEIRO DE ENGENHARIA BIOMÉDICA, 25., 17-20 de outubro, 2016, Foz do Iguaçu, PR. Resumo... Rio de Janeiro, RJ: Sociedade Brasileira de Engenharia Biomédica, 2016. p. 2336-2336.

    Abstract: Introdução: As doenças infecciosas causadas por fungos ainda representam um grande desafio para os profissionais de saúde e a comunidade científica, especialmente as infecções causadas por micro-organismos resistentes aos fármacos antifúngicos convencionais. Novas alternativas de tratamento foram estudadas, entre elas a terapia fotodinâmica (PDT) que surgiu como uma promissora modalidade terapêutica por causar a morte de micro-organismos a partir da associação de um fotossensibilizador e luz. Recentemente observamos que a PDT realizada em condições subletais aumenta a suscetibilidade do fungo Candida albicans ao fluconazol [1]. Dando continuidade a este estudo iniciamos a investigação em C. albicans que apresentam diferentes mecanismos de resistência aos antifúngicos. Assim, o presente trabalho teve o objetivo de avaliar o efeito antimicrobiano da associação de PDT e fluconazol em C. albicans que apresenta um sistema de efluxo responsável pela resistência ao antifúngico. Materiais e Métodos: Para a realização deste trabalho foi utilizado C. albicans YEM 13, uma cepa com expressão exacerbada de bomba de efluxo da família MFS (Major Facilitator Superfamily). As células foram submetidas a PDT com azul de metileno na concentração final de 50 μM e irradiadas com parâmetros subletais (=660 nm, 75 mW/cm2, 4 min)[1]. Para investigar a atividade antimicrobiana do fluconazol foram determinados os valores de concentração mínima inibitória (CMI) do crescimento celular. A CMI foi determinada pelo método de microdiluição em caldo de acordo com as normas estabelecidas pelo Comitê Europeu de Teste à Susceptibilidade Antimicrobiana (EUCAST)[2]. A solução de fluconazol (Sigma Aldrich, São Paulo, Brasil) foi preparada, considerando a potência do fármaco de 98% e a faixa de concentrações testadas foi de 0,125-64 μg/mL. Os valores de CMI foram determinados por meio da leitura da absorção em 530 nm, em espectrofotômetro (SpectraMax M4, Molecular Devices, EUA). Para cada grupo foi determinada a menor concentração da droga que promoveu a inibição ≥ 50% do crescimento em comparação ao controle livre de drogas. Foram avaliadas células C. albicans YEM 13 sem tratamento e previamente submetidas a PDT subletal. Foi utilizado como controle a cepa de C. albicans ATCC 90028 que não apresenta resistência ao fluconazol. Resultados: C. albicans ATCC 90028 apresentou valor de CMI de 0,5 μg/mL, dado compatível com os descritos na literatura. As amostras de célula YEM 13 que não foram submetidas à PDT apresentaram o valor de CMI de 64 μg/mL, que também coincide com o valor descrito na literatura [3]. Estes dados demonstram que a cepa YEM 13 apresenta um valor de CMI 128 vezes superior ao de uma cepa suscetível ao fluconazol (ATCC 90028). Confirmando nossa hipótese, o fluconazol foi mais ativo em C. albicans submetida previamente à PDT subletal. Dentro da faixa de 0,125-64 μg/mL, houve maior inibição do crescimento celular quando previamente submetido à PDT, resultando na redução do valor de CMI de 64 μg/mL para 32 μg/mL. Conclusões: Foi possível demonstrar que a PDT pode aumentar a susceptibilidade ao fluconazol em cepa de C. albicans que apresentam bombas de efluxo da família MFS. Estes resultados preliminares sugerem que a associação terapêutica entre a PDT e o fluconazol pode ser uma importante alternativa no tratamento de infecções por cepas de C. albicans que apresentam resistência a este antifúngico. Vale ressaltar que neste trabalho foram utilizadas condições subletais e resultados ainda mais promissores podem ser obtidos com a otimização dos parâmetros de irradiação.


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Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.

Autor: Maprelian

Título: loss of coolant

Tipo de publicação: Texto completo de evento

Ano de publicação: 2015

Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da International Atomic Energy Agency – IAEA , por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.

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O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.

2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.