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  • IPEN-DOC 26095

    ZACARIAS, ENIO A. ; GOMES, ALISSANDRA de M. ; JESUS, GUSTAVO P.P. de ; YOSIDAKI, VANESSA de L. ; BARTOLINI, PAOLO ; PERONI, CIBELE N. . Efficiency comparison between vectors containing the genomic or complementary DNA sequences of human growth hormone in an animal model of gene therapy. Journal of Cell Science & Therapy, v. 10, p. 34-34, 2019. DOI: 10.4172/2157-7013-C2-053

    Abstract: Our group has been working with gene therapy models for growth hormone deficiency. We are using an in vivo approach in which expression vectors containing the growth hormone (GH) gene are administered in mice, followed by electrotransference. In previous studies, elevated levels of human GH (hGH) in mice serum (~20 ng/ mL) and high growth approximation to normal mice (catch-up growth) of ~70% for body weight and of ~80% for femur length were obtained, using a plasmid containing the genomic sequence (gDNA) of GH with the ubiquitin-C promoter. On the other hand, we had an indication that the complementary sequence (cDNA) may have an advantage over gDNA in gene therapy protocols. Our objective is to carry out a comparative study between vectors containing the hGH gDNA or cDNA sequences. First, the two vectors were analyzed for in vitro expression levels by transfecting HEK-293 cells. Expression levels reached 250+50 ng hGH/mL for gDNA and 20+9.4 ng hGH/mL for cDNA transfected cells. Although in vitro expression of cDNA-containing vector was lower than that containing gDNA, we believe the cDNA vector may have better expression in vivo, due to a possible better incorporation by the muscle cells in electrotransference. Then, bioassays will be performed administering these vectors into dwarf mice, via electrotransference in the muscle. This will verify the expression profile of GH in vivo, concerning levels and durability, as well as body weight, total body, tail and femur length, mouse insulin-like growth factor-1 levels and catch-up growth.

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  • IPEN-DOC 26094

    JESUS, GUSTAVO P.P. de ; GOMES, ALISSANDRA de M. ; ZACARIAS, ENIO A. ; YOSIDAKI, VANESSA de L. ; BARTOLINI, PAOLO ; PERONI, CIBELE N. . Intramuscular growth hormone plasmid DNA eletrotransfer effects on bone quality in a murine model of osteogenesis imperfecta. Journal of Cell Science & Therapy, v. 10, p. 36-36, 2019. DOI: 10.4172/2157-7013-C2-053

    Abstract: Osteogenesis imperfecta (OI) is a congenital dysplasia of connective tissue characterized mainly by fragility and low bone density. The type I OI, a mild form of the disease, is associated with the quantitative decrease of type I collagen in the extracellular matrix, a characteristic also observed in the oim mice used in pre-clinical OI research. Previous studies have shown the efficiency of recombinant human growth hormone (GH) treatment for OI, both in animal and human models, reducing bone fragility, increasing bone density and stimulating α 1 and α 2 procollagen synthesis. This work aimed at using plasmid containing the murine GH (mGH) gene to treat oim heterozygous mice. Serological quantification of mGH by ELISA was carried out to evaluate the plasmid expression, bone density by DEXA and three-point flexion test were performed on the femurs to assess bone quality. In a short-term (3-day) trial, mGH levels of treated animals were 20.6±6.6 ng/mL, versus 3.3±2.2 ng/mL for those receiving saline and 2.3±1.3 ng/mL for the untreated wild-type group. A 90-day assay with plasmid applications at 0, 30 and 60 days was performed in parallel. The results of bone density showed greater effectiveness of the hormone during the first month of treatment, with a 34% increase in comparison with the saline group, whereas in the second month there was no significant statistical difference (p>0.05). The three-point bending test and the final analysis of bone density are currently being carried out.

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  • IPEN-DOC 26093

    GOMES, ALISSANDRA de M. ; JESUS, GUSTAVO P.P. de ; ZACARIAS, ENIO A. ; YOSIDAKI, VANESSA L. ; HIGUTI, ELIZA; RANGEL, ERIKA B.; BARTOLINI, PAOLO ; PERONI, CIBELE N. . Electrotransference of the mouse growth hormone gene associated with the administration of mesenchymal stem cells, in a murine model of osteogenesis imperfecta. Journal of Cell Science & Therapy, v. 10, p. 35-35, 2019. DOI: 10.4172/2157-7013-C2-053

    Abstract: Osteogenesis imperfecta (OI) is an inherited connective tissue disease characterized by fragility, deformity and low bone density, as well as by other clinical manifestations. Type I OI is the mildest and most common form of the disease, caused by mutation in the COL1A1 gene, resulting in the production of only ~50% of normal collagen. The corresponding animal model is the oim mouse, presenting a phenotype very similar to human type I OI. We aim, for the first time, at evaluating the electrotransference of mouse growth hormone (mGH) gene, encoding a protein that already showed therapeutic effects, together with the administration of murine mesenchymal stem cells (MSCs), for improving heterozygous oim mice phenotype. We already prepared and evaluated two populations of MSCs (bone marrow and adipose tissue) that emit red fluorescence. These are administrated in different amounts and via three routes (intravenously, intraperitoneally or locally into the femoral condyles) using the in vivo imaging system and histological sections of femur, liver and kidneys, a methodology we recently set up and adapted to our specific conditions. Then, we will administer the most efficient MSCs population combined with mGH gene electrotransfer. In this bioassay, we are ready to analyse different parameters: body weight, total body, tail and femur length, bone mineral density and femur fragility by a biomechanical flexion test. The results will indicate if the administration of GH by gene therapy, together with MSCs infusion, can be a promising treatment for improving type I OI phenotype.

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  • IPEN-DOC 26092

    ALMEIDA, SHIRLANE B. de ; VILLANI, DANIEL ; SAKURABA, ROBERTO K.; REZENDE, ANA C.P. de; SANTOS, SILAS C. ; CAMPOS, LETICIA L. . Dosimetric evaluation employing TL and OSL techniques with different luminescent materials for clinical evaluation of extremity doses using electron beams applied to Total-Irradiation-of-Skin treatments. International Journal of Modern Physics: Conference Series, v. 48, p. 1860110-1 - 1860110-9, 2018. DOI: 10.1142/S2010194518601102

    Abstract: Total-skin electron beam (TSEB) irradiation is used to deliver a homogeneous dose distribution over the entire skin surface of a patient. TSEB dosimetry is quite complex as to the evaluation and measurement of absorbed dosage in the cutaneous region. This paper evaluates the performance of different dosimetric materials, using TL and OSL dosimetry, in the extremity-dose assessment of TSEB treatments using the six-dual-field technique and an anthropomorphic phantom. Dosimeters were selected with repeatability better than ±5.0% and calibrated to 6-MeV electron-beam dosimetry. Measurements were conducted in the abdominal region as a reference point and on the extremities. Results show expected deviations ranging up to 20% in the dose received in the extremities and good results in dose assessment using all dosimetric materials tested.

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  • IPEN-DOC 26087

    LOPES, CARLA R.B.; SILVA, FLAVIA R. de O. ; FERRARI, VITOR B.; OKAMOTO, DEBORA N.; VASCONCELOS, SUZAN P. de; COURROL, LILIA C.. Facile synthesis of gold nanoparticles using Mimusops coriacea leaves extract. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: Gold nanoparticles have attracted great interest from the scientific community in recent years due to their wide variety of applications in various science areas. The green synthesis shows a sustainable alternative to obtain nanomaterials and aims to use biological materials to replace chemical reagents, traditionally used in these processes. In this work gold nanoparticles (AuNP) were synthesized using aqueous leaf of Mimusops coriacea (McAuNP). The obtained nanoparticles were characterized by different techniques, such as UV-Vis; fluorescence; FTIR; transmission electron microscopy (TEM); dynamic light scattering (DLS) and Zeta potential. Variations in the pH of the medium, concentration of the reagents and pH were applied, aiming to optimize the synthesis processes. The method to synthesize gold nanoparticles using Mimusops coriacea leaves extract presented high reproducibility and is in accordance with the principles of green chemistry and sustainability, presenting a low-cost and biocompatible alternative to obtain AuNPs. Antimicrobial action of McAuPs was tested using minimum inhibitory concentration test.

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  • IPEN-DOC 26086

    VIEIRA JUNIOR, NILSON D. ; SAMAD, RICARDO E. ; MALDONADO, EDISON P.. Compact laser accelerators towards medical applications: perspectives for a Brazilian program. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: Laser particle acceleration is now in a new trend due to an enormous worldwide effort to increase the peak power of femtosecond lasers, as well as increasing their average power in order to make them useful for applications. The leading example is the Extreme Light Infrastructure in Europe, which has led to the establishment of three large research facilities in the Czech Republic, Romania and Hungary that host some of the most powerful lasers worldwide (above PW peak power). This action is now being followed by the USA LaserNetUS initiative, that comprises all the big laser facilities in US, and similar efforts also happen in Asia. We are starting a program to establish a laser accelerator facility in Brazil, aiming to produce radiation (electrons, protons and X rays) to be used in medical applications, like X ray and electron therapy, nuclear reactions and, eventually, protontherapy.

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  • IPEN-DOC 26085

    ZUFFI, ARMANDO V.F. ; ALMEIDA, ANDREIA A. ; VIEIRA JUNIOR, NILSON D. ; SAMAD, RICARDO E. . Below threshold harmonics dependence with phase-matching parameters in argon. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: This work reports the generation of Below Threshold Harmonics generated in Argon by ultrashort laser pulses. The 3rd, 5th, 7th and 9th harmonics of the laser were generated in the UV and VUV regions, and the frequency conversion occurred in flowing gas in a glass nozzle into a vacuum chamber. The harmonics generated show a blue-shift and an efficiency that depend on the laser pulses intensity and also on the gas pressure. These parameters determine the phase-matching condition, which governs the energy conversion from the laser into the harmonics, and this study shows that is possible to tune the harmonics intensity and wavelength, providing a versatile light source.

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  • IPEN-DOC 26084

    PENHA JUNIOR, TARCISO; RODRIGUES, MONICA de A.P.; ZEZELL, DENISE M. ; VIEIRA JUNIOR, NILSON D. ; SAMAD, RICARDO E. ; DUTRA-CORREA, MARISTELA. Evaluation of the adhesive strength in dentin after irradiation with Ti:Sapphire ultrashort laser pulses. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: This study was done to evaluate whether the irradiation of dentine with ultrashort laser pulses prior to adhesive procedures contributes to increase the adhesive resistance to microtraction essays. Twenty-four human teeth (third molars) were used, divided into 4 groups (n=6): standard adhesive procedures with etch-rinse adhesive were used in the control group, and in the experimental groups, the dentin was irradiated by 25 fs pulses prior to the adhesive procedures, with varying fluences. One tooth from each group was used to evaluate its surface roughness. After 24h, the teeth were sectioned with perpendicular cuts, producing toothpicks that were submitted to the microtraction test. The results showed that the groups irradiated with fluences under 4 J/cm² presented similar results among themselves, comparable to the control group, while the group irradiated with 8 J/cm² showed lower adhesive strength. We propose that the adhesive strength and surface roughness reduction resulting from the fluence increase is probably related to the shielding arising from an electron plasma formation during the ablation, decreasing the material removal efficiency. Nevertheless, the lower energy densities did not affect the adhesiveness, maintaining values similar to the control.

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  • IPEN-DOC 26083

    WETTER, NIKLAUS U. ; GOMES, ANTONIO A. ; SILVA, DIEGO S. da ; ROSSI, WAGNER de . Production of a microfluidic random laser using ultrashort laser pulses. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: A random rhodamine laser system is produced on board of a femtosecond laser machined microfluidic system. When pumped by a nanosecond pulsed laser beam at 532 nm, laser emission at 610 nm is observed together with the linewidth narrowing typical of random lasers. The system can be easily integrated as an optofluidic component into microfluidic circuits for assessment of optical parameters on board of the lab-on-chip.

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  • IPEN-DOC 26082

    ROCHA, GILBERTO A. dos S. ; VIEIRA JUNIOR, NILSON D. ; SAMAD, RICARDO E. . Measurement of optical materials ablation threshold dependence on the dispersion of ultrashort pulses. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: The ablation threshold for ultrashort pulses of common optical materials (BK7 glass, Sapphire and Fused Silica), was measured using the D-Scan technique, for positive and negative dispersions covering pulse durations from 30 fs to 100 fs. We observed that the ablation threshold for a single shot and at saturation increase with the pulse duration and the material bandgap, and also that defects which decrease the threshold values accumulate faster as the material bandgap increases.

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  • IPEN-DOC 26081

    MALDONADO, EDISON P.; SAMAD, RICARDO E. ; ZUFFI, ARMANDO V.F. ; TABACOW, FABIO B.D. ; VIEIRA JUNIOR, NILSON D. . Self-modulated laser-plasma acceleration in a H2 gas target, simulated in a spectral particle-in-cell algorithm: wakefield and electron bunch properties. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: We evaluate the results of self-modulated, laser wakefield acceleration of electrons in homogeneous, 150-μmthick hydrogen gas target, simulated using the spectral particle-in-cell algorithm FBPIC. Considering a single 2-TW laser pulse at 800-nm, which generates ionization and plasma displacement at relativistic intensities, we discuss the resultant wakefield phases, wave-breaking, and the ejected electron bunch properties: charge, length, divergence and energy, also comparing with experimental results.

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  • IPEN-DOC 26080

    BERECZKI, ALLAN ; WETTER, NIKLAUS U. ; CRUZ, FLAVIO C. da . Dynamically stable continuous single frequency green ring laser. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: A single-frequency ring laser using two standard commercial diode-pumped Nd:YAG modules is demonstrated. Employing a dynamically stable resonator design, multi-longitudinal mode operation at 1064 nm with 53 W of output power was obtained. When inserting a LBO crystal in the resonator, 1.8 W of single-sided, single-frequency output at 532 nm was achieved. The measured linewidth was 3.6 MHz, close to the resolution limit of the scanning etalon used to measure the longitudinal mode structure.

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  • IPEN-DOC 26091

    VELO, A.F. ; CAVALLARO, F.A.; AMADEU, R. de A. ; SANTOS, R.S. dos ; MARTINS, J.F.T.; CARVALHO, D.V.S. ; MESQUITA, C.H. de ; HAMADA, M.M. . Gamma computed tomography performance for petrophysical characterization of sandstone rocks. In: WORLD CONGRESS ON INDUSTRIAL PROCESS TOMOGRAPHY, 9th, September 2-6, 2018, Bath, UK. Proceedings... ISIPT, 2018. p. 249-257.

    Abstract: The gamma ray tomography techniques for industrial processes evaluation have been pointed out as the most promising in order to visualize the structure and the distribution of solids, liquids and gases inside multiphase systems, such as industrial columns or pipes, without interrupting the operation in pharmaceutical, biochemical, petrochemical and chemical industries. The reservoir rocks of fluids have, also, multiphase mixtures in their interior, since the fluids stored in the pore spaces within the reservoir rocks could be gas, oil, and water. However, no studies related to gamma tomography for analysis of oil reservoir rocks have been found in the literature. One type of rock of economic interest is the tar sand rock which has a great potential to act as reservoirs of oil, thus the knowledge of its petro-physical properties related to the filling of fluids in their pores; its structural properties, its internal geometry can contribute significantly to the exploration and recovery of the hydrocarbons of the rocks reservoirs, providing subsidies to the oil engineers in the recovery of hydrocarbons (oil) in their interior, having a significant economic relevance. In this work, the tar sand rock was characterized using the 3th generation gamma-ray industrial process tomography technique developed at IPEN /CNEN-SP. The internal arrangement, distribution of the pores, mineral composition, the fluid and mineral densities of the analysed rocks were evaluated. A high spatial resolution was obtained in the reconstructed image.

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  • IPEN-DOC 26090

    ROLINDO, N.C. ; TESSARO, A.P.G. ; SMITH, R.B. ; CAMPOS, C.; MARUMO, J.T. ; VICENTE, R. . Disused sealed radioactive sources: inventory and characterization at IPEN. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26089

    MORAES, MARCIA C.D. ; PEREIRA, DAISA L. ; ANA, PATRICIA A. da; FREITAS, ANDERSON Z. de ; ZEZELL, DENISE M. . Optical attenuation coefficients obtained through OCT correlates to microhardness in dental human enamel irradiated with Nd: YAG and submitted to demineralization in vitro. In: RECHMANN, PETER (Ed.); FRIED, DANIEL (Ed.) SPIE PHOTONICS WEST; SPIE BIOS, February 2-7, 2019, San Francisco, USA. Abstract... Washington, USA: SPIE, 2019. (Proceedings SPIE 10857, Lasers in Dentistry XXV).

    Abstract: This work aims was to correlate the changes in the optical attenuation coefficients obtained through the OCT technique with the values obtained in Knoop sectional microhardness tests over time in dental human enamel samples irradiated with the Nd: YAG laser and Acid Phosphate Fluoride (APF), aiming the prevention of caries lesions in vitro. After Ethical Committee approval, 160 enamel samples, obtained from 40 human tooth molars, were divided into 4 groups: Control group (where no treatment was performed); Fluoride group (APF - fluoride phosphate acidulated for 4 minutes); Fluoride-Laser group: APF followed by irradiation with Nd:YAG laser (DE = 84.9 J/cm2, contact mode, with the use of carbon paste as photoabsorver); Laser-fluoride group (irradiation with Nd:YAG laser followed by APF). The samples of all groups were subjected to pH cycling during 20 days. On days 5, 10, 15 and 20, 10 samples from each group were removed from the cycling for the Knoop sectional microhardness test. Two samples of each group, at each time, were randomly selected for the analysis with FTIR-ATR (Fourier transform infrared spectroscopy associated with attenuated total reflection technique). The analysis by ATR-FTIR showed changes in the chemical composition of the samples of the irradiated groups in relation to Control and Fluoride group. There was correlation between the values of sectional microhardness tests and the measured optical attenuation coefficient by OCT in irradiated dental enamel, showing that the association between fluoride application and Nd:YAG laser irradiation is an important tool for the prevention of tooth enamel demineralization.

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  • IPEN-DOC 26088

    MAYNARD, ISABELLA F.N.; CAVALCANTI, ELIANE B.; MARTINS, ELAINE A.J. ; SILVA, LARISSA L. da ; PIRES, MARIA A.F. ; MARQUES, MARIA N.. Avaliação da presença de desreguladores endócrinos em água subterrânea e tratada em uma área rural. In: ARENZON, ALEXANDRE (Ed.); NUNES, MARIA E.T. (Ed.); BOTTA, CLARICE M.R. (Ed.); ESPINDOLA, EVALDO L.G. (Org.); NOVELLI, ANDREA (Org.) CONGRESSO BRASILEIRO DE ECOTOXICOLOGIA, 15th, 1-4 de setembro, 2018, Aracaju, SE. Resumo expandido... Campinas: Sociedade Brasileira de Ecotoxicologia, 2018. p. 672-674.

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  • IPEN-DOC 26079

    SILVA, DIEGO S. da; KASSAB, LUCIANA R.P.; JIMENEZ-VILLAR, ERNESTO ; WETTER, NIKLAUS U. . Optimization of BGO Er/Yb doped pedestal waveguide amplifiers with Si nanostructures. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: In this work we review the recent advances in pedestal waveguide amplifier fabrication. The improvement of conventional photolithography and plasma etching methods brings advantages that benefit light guiding and reduce propagation losses, mainly in the 3rd telecommunication windows (λ~1550 nm). Yb3+/Er3+ codoped Bi2O3-GeO2 thin films, with and without Si nanostructures, are obtained by RF Magnetron sputtering deposition and are used as core layer of 500 nm height in the pedestal waveguides. Choosing an appropriate amount of these silicon nanostructures inside the rare-earth waveguides we achieve pump light scattering and at the same time very little scattering at the signal wavelength. The overall effect is again enhancement of 50% thus opening possibilities for potential applications in integrated optics.

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  • IPEN-DOC 26078

    MOTA, ANA P.P.; SILVA, SALMO P.; BAPTISTA, ALESSANDRA; BARROS, AMANDA F.F.; NAVARRO, RICARDO S.; GARCIA, LIVIA; RIBEIRO, MARTHA S. ; NUNEZ, SILVIA C.. Analysis of the treatment of knee osteoarthritis using photobiomodulation performed with a low power laser. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

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  • IPEN-DOC 26077

    ANA, PATRICIA A.; PEREIRA, DAISA de L. ; FERREIRA, ELIZABETE dos S.; FIGUEREDO, DANIELA C.; DAGUANO, JULIANA K.F.B.; ZEZELL, DENISE M. . Advances in the prevention and monitoring of root dentin demineralization using lasers. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: The increase in the life expectancy and the longer permanence of the teeth in the oral cavity also led to an augment in the prevalence of root caries lesions. These lesions require more attention because of their rapid progression and difficulty in early diagnosis and monitoring. In this context, the irradiation of the tissues with high intensity lasers has been shown as an important way for preventing lesion formation because lasers chemically modify the irradiated dental hard tissues and make them more resistant to acid challenge. In addition, the association with ceramic biomaterials may allow additional remineralizing results. Together with therapeutics, the effective early diagnosis of incipient lesions is indispensable. Techniques that use lasers, such as optical coherence tomography, have also been promising in this aspect because they allow the early diagnosis and monitoring of demineralizations with high resolution and in a non-detrimental way. This article aims to show the actions of high intensity laser therapies when associated or not with biomaterials, on the prevention and remineralization of root caries lesions, as well as the effectiveness of optical coherence tomography in the diagnosis and monitoring the effects of the treatments in these lesions.

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  • IPEN-DOC 26076

    FIGUEREDO, DANIELA C.; DEL VALLE, MATHEUS; ZEZELL, DENISE M. ; DAGUANO, JULIANA K.M.B.; ANA, PATRICIA A.. Radiotherapy compositional and mechanical effects evaluation in radicular dentin by FTIR spectroscopy and microhardness testing. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: Head and neck cancers are responsible for 400 to 600 thousand of new cancer cases per year over the world, presenting a mortality rate of 223 to 300 thousand per year. Radiotherapy can be used as a definitive, adjuvant or palliative treatment. One of the radiotherapy indirect side effect is the radiation-related caries, characterized by presenting a painless, rampant and rapid progression. Hard tissues can be affected by the ionizing radiation, changing their composition, morphology and mechanical properties, although there is a lack of studies relating these changes with radiation caries. Thus, considering that radicular dentin is a tissue with a high incidence of radiation caries, this study aimed to evaluate the compositional and mechanical changes of this tissue when submitted to radiotherapy. To that, it was conducted an in vitro study with 45 bovine teeth roots, where 90 radicular dentin slabs of 4 x 4 cm were obtained. The samples were immersed in artificial saliva and submitted to radiotherapy using cobalt-60, simulating doses for head and neck cancers of 2 Gy per day per 6 weeks, accumulating a total of 60 Gy. FTIR spectroscopy and microhardness testing were performed before and after the radiotherapy. The spectra were analyzed in six IR fingerprint bands: amide I, amide II, amide III, phosphate, carbonate ν2 and carbonate ν3ν4. Statistical analysis was performed by Student’s t-test and Wilcoxon test, considering the level of significance of 5%. The carbonate ν3ν4 and the amide III areas decreased after the radiotherapy, presenting significant statistical difference between both periods. These findings can be related to inorganic and organic changes due to free radicals formation. The Knoop microhardness value decreased after the radiotherapy, also showing statistical difference, which can be associated to collagen reorganization or denaturation and to inorganic changes, leading the tissue to be more prone to cracks formation. It can be concluded that the radiotherapy affects the compositional and mechanical properties of the radicular dentin, and this fact should be considered in future studies.

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  • IPEN-DOC 26075

    GONÇALVES, KARINA de O.; COURROL, LILIA C.; CORAZZA, FULVIO ; VIEIRA, DANIEL P. . Silver and silver-iron nanoparticles synthesized by photoreduction for applications in cancer therapy. In: SBFOTON INTERNATIONAL OPTICS AND PHOTONICS CONFERENCE, October 7-9, 2019, São Paulo, SP. Proceedings... 2019.

    Abstract: Metal nanoparticles have been extensively studied for various purposes including therapeutic applications for cancer. In this study, nanoparticles of silver and silver-iron with aminolevulinic acid (ALA) were synthesized using (ALA:AgNPs and ALA:AgFeNPs) the photoreduction method with a 300 W xenon lamp, characterized by UV/vis absorption, zeta potential, x-rays diffraction, FTIR and transmission electron microscopy. The sizes obtained were ~ 23 nm for silver and ~ 12 nm for iron. Cytotoxicity assays were performed on breast tumor cells (MCF-7) and prostate cancer cells (LNCaP). The results obtained showed that it was possible to synthesize silver and silver-iron nanoparticles by the photoreduction method, and to functionalize their surfaces with ALA, which was delivered to the cells and converted to protoporphyrin IX (PpIX).

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  • IPEN-DOC 26074

    VAN VELZEN, LEO; ROBBINS, REBECCA A.; MARUMO, JULIO T. ; FERNANDO, KAPILA; VAN ISEGHEM, PIERRE; KASHIWAGI, MAKOTO. International network for nuclear waste characterization IAEA-LABONET: facts and future. In: SMETSERS, RONALD (Ed.) EUROPEAN IRPA CONGRESS, 5th, June 4-8, 2018, The Hague, Netherlands. Proceedings... International Radiation Protection Association, 2019. p. 439-444.

    Abstract: LABONET was launched early 2011 by the International Atomic Energy Agency (IAEA) as an international network on nuclear waste characterization. Its objective is to improve the quality of, and harmonize, activities related to the radioactive waste characterization in IAEA Member States. It is widely accepted that proper characterization of radioactive waste through its entire flow-sheet is a key activity and will improve the sustainability of waste (e.g. immobilized waste packages). In particular the needs and problems in radioactive waste characterization in the participating countries are a main concern within LABONET, as the programs are not elaborated to the same level in the various countries. LABONET wants to facilitate the exchange of international experience in the application of proven, quality assured practices for the characterization of waste and waste packages. This will be beneficial for the less developed countries. The objectives of LABONET are achieved via different actions: a) exchanging information and expertise via presentations and discussions at technical meetings; b) expert meetings on particular topics of interest, for instance e-learning and e-platforms; c) training sessions in less developed countries, for instance, on nondestructive assay of waste packages; d) facilitate the exchange of information amongst its members ; and e) assist Member States in establishing characterization plans that are cost effective and of good quality. LABONET is continuously encouraging institutions or professionals who need some assistance or can help in solving questions about characterization to be a member. Currently, LABONET is preparing for its future, including projects addressing common problems of its members. Aiming at the dissemination of this important network for the professionals involved in radioactive waste characterization, this paper will discuss the following issues: (1) the objectives of LABONET, (2) its structure, membership and organization of meetings, (3) some achievements, and (4) plans for the future.

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  • IPEN-DOC 26073

    ALBANO, A.M.S. ; ARTHUR, V. . Efeito da radiação gama na inibição da germinação de ervilha in natura (Pisum sativum L.). In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26072

    CAMPOS, R.F. ; CAMPOS, V.P. ; MITAKE, M.B. ; ARAUJO, E.B. . Analise dosimétrica de um laboratório de radiobiodistribuição in vivo usando CaSO4:Dy. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26071

    SILVA, T.M.; KODAMA, Y. ; SOMESSARI, S.L. ; OMI, N.M. ; NORMANTON, K.A.F.; VASQUES, F.M.F. ; DUARTE, C.L. ; SAMPA, M.H.O. ; CALVO, W.A.P. . Desenvolvimento de procedimentos e metodos de monitoração individual e de área em uma unidade móvel de irradiação por feixe de elétrons. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26070

    COELHO, ANASTACIA L.L.P.B.; PINHEIRO, ANGELICA L.L.P.; SIMPSON, STEPHANIE C.; ZEITUNI, CARLOS ; ROSTELATO, MARIA E.C.M. . A radiação ionizante como forma de tratamento nas mulheres com câncer de colo de útero em Araguaína –TO nos anos de 2000 a 2015. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

    Abstract: O câncer vem se apresentando como um grave problema de saúde pública em todo mundo as sociedades globais, especialmente em países subdesenvolvidos. Em 2005, de um total de 58 milhões de mortes ocorridas no mundo, o câncer foi responsável por 7,6 milhões (13%). Desse total, mais de 70% ocorreram em países de média ou baixa renda. Atualmente, o câncer é a segunda causa de morte no Brasil (10,3% do total), excluídas as causas indeterminadas, ficando atrás somente de doenças cardiovasculares . Para 2018, há uma estimativa de 16.370 novos casos, sendo que, 2.300 se encontram na região Norte do país. O câncer de colo uterino é o segundo tipo de câncer mais frequente entre as mulheres em todo o mundo. A sua frequência, entretanto, é bastante variável de acordo com o desenvolvimento do país estudado, sendo que 83% dos casos registrados no mundo acontecem em países em desenvolvimento, onde o risco cumulativo é de 1,5% aos 65 anos. Este trabalho trata-se de um estudo descritivo, retrospectivo, quantitativo-interpretativo, com analise de dados secundários do período de 2000 a 2015 do Registro Hospitalar de Câncer pelo Sistema de Informação em Saúde (SIS-RHC), vinculado ao Hospital Regional de Araguaína. Os dados foram tabulados em planilhas eletrônicas do excel onde foram obtidas variáveis estatísticas e frequência para análise. . Foram analisadas 2.664 mulheres com câncer de Colo de Útero no Hospital Regional de Araguaína. Sendo divididas em 17 variáveis na “Ficha de Tumor”; o histórico de bebida alcoólica e de tabaco apresentaram as maiores porcentagens de ausência de preenchimento (mais de 31%). Em seguida, 25,9% das fichas não tiveram o preenchimento da escolaridade. De uma forma geral, pode-se notar que das 17 informações utilizadas neste estudo, 55,7% das fichas continham todas as informações e 12, 2% tinham 4 ou mais informações ausentes. Observa-se entre o tempo de diagnóstico e tratamento que as mulheres diagnosticadas tardiamente apresentaram, em média, tempos maiores entre as duas ações. a maioria das pacientes tiveram um diagnóstico tardio, com isso a radioterapia se tornou a principal forma de tratamento.

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  • IPEN-DOC 26069

    ALVARENGA, T.S. ; POLO, I.O. ; PEREIRA, W.W.; CALDAS, L.V.E. . Anisotropia da fonte de 241AmBe do laboratório de calibração com nêutrons do IPEN. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26068

    LITVAC, D. ; CALDAS, L.V.E. . Caracterização dosimétrica do LiF-nrpb para calibração de aplicadores clínicos de betaterapia. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26067

    SANTOS, W.S.; NEVES, L.P.; PERINI, A.P.; CALDAS, L.V.E. . Uso de modelagem computacional para avaliação da exposição médica e ocupacional durante procedimento de cardiologia intervencionista. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26066

    CASTRO, M.C. ; SILVA, N.F. ; CALDAS, L.V.E. . Some characterization tests for an extrapolation chamber in CT standard beams in a specific chamber depth. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26065

    ANTONIO, P.L. ; CALDAS, L.V.E. . Comportamento do sinal TL/OSL e PTTL/PTOSL após tratamento térmico pós-irradiação com fonte de 60Co, em amostras de LiF:Mg,Ti e CaSO4:Dy. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26064

    LIMA, B.L.; ALMEIDA, J.S. ; POTIENS, M.P.A. ; PELISSONI, R.A.; SAPIENZA, M.T.; BUCHPIGUEL, C.A.; WILLEGAIGON, J.. Evaluation of biokinetics and dosimetry in [131I]-NaI therapies: whole-body images quantification versus lower limb region. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26063

    TAVARES, P.S.; RODRIGUES JUNIOR, O. ; CAMPOS, L.L. . Princípio de investigação do dosímetro Fricke Gel modificado utilizando um equipamento de CT Óptico. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26062

    SAUEIA, C.H.R. ; NISTI, M.B. ; MAZZILLI, B.P. . Determinação de Cs-137 e radionuclídeos naturais em sedimentos do Sistema Estuário da Baixada Santista, Brasil. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26061

    SILVA, N.F. ; SILVA, T.F.; CASTRO, M.C. ; LUZ, H.N. da; CINTRA, F.B. ; CALDAS, L.V.E. . Simulation of a TH-GEM based detector for standard mammography-quality beam dosimetry using the MCNP5 code. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26060

    SILVA, E. ; SANTOS, L.R. ; ASSEMANY, L.P.F. ; POTIENS, M.P.A. . Evaluation of the performance of radioprotection ionization chambers used in radiometric survey of radiology clinical systems. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26059

    NISTI, M.B. ; CAMPOS, M.P. ; SILVA, G.M. ; MAZZILLI, B.P. . Determinação da taxa de exalação do 222Rn no solo do IPEN. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26058

    TAMURA, T.M.; SOUZA, R.E.; NEVES, L.P.; PERINI, A.P.; SANTOS, W.S. . Cálculo de fator de conversão para dose absorvida em atividade de navegação utilizando o método Monte Carlo e um simulador antropomórfico virtual. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26057

    CORREIA, R.W. ; ROSTELATO, M.E.C.M. ; ZEITUNI, C.A. . Estudo e calibração de detector HPGe para análise radionuclídica de iodo-125. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26056

    ABREU, R.T. ; ANGELOCCI, L.V. ; NOGUEIRA, B.R. ; SANTOS, H.N. ; ZEITUNI, C.A. ; ROSTELATO, M.E.C.M. . Dose-rate constant evaluation of a new 192-Ir brachytherapy source using Monte-Carlo and experimental parameters. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26055

    BAPTISTA, T.S. ; ZEITUNI, C.A. ; RODRIGUES, B. ; MOURA, J. ; ROSTELATO, M.E. . Efficiency test on three types of sanitizers for cleaning sealed radioactive sources for brachyterapy. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26054

    ANDRADE, M.A.B.; ALVES, C.O.; FIN, A.P.C.; SOARES, F.A.P.; SAVI, M. ; POTIENS, M.P.A. . Visual impact of infill percentages for 3D printed radiologic simulators. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26053

    PRADO, E.S.P. ; MIRANDA, F.S.; PETRACONI, G.; POTIENS JUNIOR, A.J. . Tratamento de rejeitos radioativos compactáveis aplicando a tecnologia plasma para redução volumétrica. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26052

    MARTINS, E.W. ; BUENO, L.K. ; POTIENS, M.P.A. . Implementação de uma instalação para implantação da nova metodologia de calibração de ativímetros. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26051

    DIAS, A.J.R. ; VILELA, A.N. ; VICENTE, R. ; DELLAMANO, J.C. . Acidentes radiológicos: dados que auxiliam a proteção radiológica. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26050

    OLIVEIRA, J.J.; VICENTE, R. . Relevância radiológica relativa: Angra 1 e 2. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26049

    TESSARO, A.P.G. ; SMITH, R.B. ; ROLINDO, N.C. ; VICENTE, R. . Opening the Goiania accident unburied waste packages. In: INTERNATIONAL JOINT CONFERENCE RADIO, September 16-20, 2019, São Paulo, SP. Resumo expandido... Maringá, PR: Sociedade Brasileira de Proteção Radiológica, 2019.

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  • IPEN-DOC 26048

    GASPARIAN, P.B.R. ; YOSHIMURA, E.M.; UMISEDO, N.K.; CAMPOS, L.L. ; MALTHEZ, A.L.M.C.. Study of the dosimetric properties of CaSO4:Dy using OSL technique. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 326-326.

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  • IPEN-DOC 26047

    SILVA, A.M.B.; JUNOT, D.O. ; CALDAS, L.V.E. ; SOUZA, D.N.. TL and OSL characterization of CaSO4:Tb, CaSO4:Tb,Ag, and CaSO4:Tb,Ag(NP). In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 321-321.

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  • IPEN-DOC 26046

    POLO, IVON O. ; CALDAS, LINDA V.E. . SOL-GEL α-Al2O3 detectors: TL and OSL response to beta radiation beams. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 317-317.

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  • IPEN-DOC 26045

    JUNOT, DANILO O. ; SOUZA, DIVANIZIA N.; CALDAS, LINDA V.E. . The influence of the preparation route in the TL/OSL signal of CaSO4:Eu,Ag samples. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 310-310.

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  • IPEN-DOC 26013

    ANTONIO, PATRICIA L. ; CALDAS, LINDA V.E. . Phototransfer analysis on TL and OSL responses of LiF:Mg,Ti (TLD-100) after exposure to 60Co radiation. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 302-302.

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  • IPEN-DOC 26012

    ANTONIO, PATRICIA L. ; CALDAS, LINDA V.E. . Influence of the thermal treatment on the PTTL and PTOSL signals from different natural materials. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 301-301.

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  • IPEN-DOC 26044

    VILLANI, D. ; MORENO, C.S.; SAKURABA, R.K.; GONÇALVES, V.D.; CAMPOS, L.L. . Optically stimulated luminescence dosimetry characterization with clinical photon beams and LINAC measurements. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 299-299.

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  • IPEN-DOC 26043

    VENEZIANI, G.R. ; MATSUSHIMA, L.C.; GAGLIARDO, K.M.; CARVALHO, T.P.A.; SAKURABA, R.K.; CAMPOS, L.L. . Development of phantom using 3D printer for veterinary radiosurgery. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 297-297.

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  • IPEN-DOC 26042

    SILVA, NATALIA F. ; SILVA, TIAGO F.; CASTRO, MAYSA C. ; LUZ, HUGO N. da; CINTRA, FELIPE B. ; CALDAS, LINDA V.E. . Simulation of geometry and materials of the TH-GEM based detector for radiation dosimetry. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 253-253.

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  • IPEN-DOC 26041

    BARRERA, GERARDO R.; ALMEIDA, ADRIEL S.; JUNOT, DANILO O. ; SOUZA, DIVANIZIA do N.. Synthesis and TL and OSL characterization of (MgB2O4-MgB4O7): Ce:Li and (MgB2O4-MgB4O7): Dy:Li glasses for dosimetry. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 216-216.

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  • IPEN-DOC 26040

    NASCIMENTO, BRUNA C.; FRIMAIO, AUDREW ; BARRIO, RAMON M.M.; SIRICO, ANA C.A.; COSTA, PAULO R.. Comparative analysis of the transmission properties of radiologically equivalent materials. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 212-212.

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  • IPEN-DOC 26039

    FRIMAIO, AUDREW ; NASCIMENTO, BRUNA C.; BARRIO, RAMON M.M.; CAMPOS, LETICIA L. ; COSTA, PAULO R.. X-ray spectrometry applied for determination of linear attenuation coefficient of tissue-equivalent materials. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 207-207.

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  • IPEN-DOC 26038

    CASTRO, MAYSA C. ; SILVA, NATALIA F. ; SANTOS, LUCAS R. ; CINTRA, FELIPE B. ; CALDAS, LINDA V.E. . Evaluation of an extrapolation chamber for dosimetry in computed tomography beams using Monte Carlo code (MCNP5). In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 204-204.

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  • IPEN-DOC 26037

    SANTOS, CARLA J.; SANTOS, WILLIAM S.; NEVES, LUCIO P.; BELINATO, WALMIR; CALDAS, LINDA V.E. ; PERINI, ANA P. . Dose determination in pediatric interventional cardiology procedures: Monte Carlo approach. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 191-191.

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  • IPEN-DOC 26036

    SANTOS, WILLIAM S.; SANTOS, CARLA J.; NEVES, LUCIO P.; BELINATO, WALMIR; CALDAS, LINDA V.E. ; PERINI, ANA P. . Numerical dosimetry in brachytherapy to variable mama sizes using two different types of 125I seeds. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 190-190.

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  • IPEN-DOC 26035

    NEVES, LUCIO P.; BORGES, ADRIANE; SOARES, MARIA R.; BELINATO, WALMIR; SANTOS, WILLIAM S.; CALDAS, LINDA V.E. ; PERINI, ANA P. . Computational dosimetry in a pediatric iCAT procedure using a virtual antropomorphic phantom. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 189-189.

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  • IPEN-DOC 26034

    SOUZA, LUCAS W.G.; POZZO, LORENA ; PERINI, ANA P. ; BELINATO, WALMIR; SANTOS, WILLIAM S.; CALDAS, LINDA V.E. ; NEVES, LUCIO P.. Monte Carlo simulation of microPET/CT occupational exposure using 18F and 68Ga tracers. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 179-179.

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  • IPEN-DOC 26033

    SILVA, ROGERIO M.V.; BELINATO, WALMIR; SANTOS, WILLIAM S.; PERINI, ANA P. ; NEVES, LUCIO P.; SANTOS, CARLA J.; SOUZA, DIVANIZIA N.. Low cost electron irradiator using 90Sr+90Y sources. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 178-178.

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  • IPEN-DOC 26032

    MATSUSHIMA, L.C.; VENEZIANI, G.R. ; SAKURABA, R.K.; CAMPOS, L.L. . Verification of absorbed doses using thermoluminescent detectors and mapping of isodose curves in IMRT planning. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 177-177.

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  • IPEN-DOC 26031

    MARTINS, ELAINE W. ; CARDOSO, JOÃO V.; POTIENS, MARIA da P.A. . Paediatric phantom performance evaluation in computed tomography radiation standard beams. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 176-176.

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  • IPEN-DOC 26030

    AMARAL, CAIO E.S.; LIMA, CAIO L.; BELINATO, WALMIR; NEVES, LUCIO P.; PERINI, ANA P. ; SANTOS, WILLIAM S.; ALMEIDA, EDSON P.B. de; NAVARRO, MARCUS V.T.. Simulation of a laboratory for the radiation detectors calibration. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 103-103.

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  • IPEN-DOC 26029

    LIMA, CAIO L.; AMARAL, CAIO E.S.; BELINATO, WALMIR; NEVES, LUCIO P.; PERINI, ANA P. ; SANTOS, WILLIAM S.; ALMEIDA, EDSON P.B. de; NAVARRO, MARCUS V.T.. Computational simulation of the detectors designed for computer tomography. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 102-102.

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  • IPEN-DOC 26028

    CORTEZ, BRUNA ; CHUBACI, JOSE F.D.; GOMES, MONISE B. ; OLIVEIRA, LETICIA M. ; SATIRO, LUCAS C. ; ROCCA, RENE R.; ARIZACA, EDY E.C.; WATANABE, SHIGUEO. Dating sediments from a terrace found in Iguape - Icapara in southeast coast in the state of São Paulo, Brazil. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 85-85.

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  • IPEN-DOC 26027

    GOMES, MONISE B. ; CORTEZ, BRUNA ; OLIVEIRA, LETICIA M. de ; CARMO, LUCAS S. do ; CHUBACI, JOSE F.D.; ROCCA, RENE R.; WATANABE, SHIGUEO. Dating of shells from Pântano da Malhada, Rio de Janeiro. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 81-81.

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  • IPEN-DOC 26026

    GROPPO, DANIELA P. ; SARAIVA, CRYSTIAN W.C.; CALDAS, LINDA V.E. . Determination of the penumbra width of Elekta SRS Cone Collimator for 6 MV FF and 6 MV FFF energies using Gradient-Based Edge Detection. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 72-72.

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  • IPEN-DOC 26025

    FONSECA, T.C.F.; SENIWAL, B.; MENDES, A.M.; BELO, M.C.L.; LACERDA, M.A.S.; MENDES, M.B.; PAIXÃO, R.L.; JOANA, G.S.; SANTANA, P.; MARQUES, J.; SQUAIR, L.P.; ANTUNES, P. ; YORIYAZ, H. ; BASTOS, F.. MCMEG: InterComparison exercise on radiotherapy assessment prostate dose. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 66-66.

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  • IPEN-DOC 26024

    SOUZA, PAULO R.D. de ; RODRIGUES, BRUNA T. ; MACHADO, LUCAS K. ; ZEITUNI, CARLOS A. ; ROSTELATO, MARIA E.C.M. . Evaluation of dose received in adjacent organs in the dosimetric plan of lung cancer. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 64-64.

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  • IPEN-DOC 26023

    SOARES, MARIA R. ; SANTOS, WILLIAM S.; NEVES, LUCIO P.; PERINI, ANA P. ; MAIA, ANA; BELINATO, WALMIR; CALDAS, LINDA V.E. . Computational modeling of thyroid shields and lead eyewear and the impact on the absorbed doses of eye lens and thyroid gland in CBCT exams. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 56-56.

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  • IPEN-DOC 26022

    BELINATO, W.; ALMEIDA, E.P.B. de; NEVES, L.P.; PERINI, A.P. ; CALDAS, L.V.E. ; SANTOS, W.S.. Occupational exposures in PET procedures with 18F-FDG. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 55-55.

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  • IPEN-DOC 26021

    ASSEMANY, LADYJANE P.F. ; RODRIGUES JUNIOR, ORLANDO ; POTIENS, MARIA da P.A. . Evaluation of 3D printing filaments for construction of a pediatric phantom for dosimetry in CBCT. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 54-54.

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  • IPEN-DOC 26020

    ALVARENGA, TALLYSON S. ; POLO, IVON O. ; PEREIRA, WALSAN P.; SILVA, FELIPE S.; FONSECA, EVALDO S.; CALDAS, LINDA V.E. . Contribution of the scattered radiation on the neutron beam fluence in the neutron calibration laboratory at IPEN. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 48-48.

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  • IPEN-DOC 26019

    ALMEIDA, S.B. ; VILLANI, D. ; SAKURABA, R.K.; REZENDE, A.C.P.; CAMPOS, L.L. . Comparison between Al2O3:C pellets and DIODEs for TSEB in vivo dosimetry using an anthropomorphic phantom. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 47-47.

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  • IPEN-DOC 26018

    SILVA-CARRERA, BETZABEL N. ; CANO, NILO F.; WATANABE, SHIGUEO. Low dose radiation dosimetry using natural blue quartz crystal by TL technique. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 39-39.

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  • IPEN-DOC 26017

    COSTA, NATHALIA A. ; POTIENS, MARIA da P.A. ; PATALLO, ILEANA S.; DIMITRIADIS, ALEX. Phantom development and implementation for Gamma Knife® dosimetry. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 24-24.

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  • IPEN-DOC 26016

    CARMO, L.S. do ; WATANABE, S. ; SILVA, R.J.; CHUBACI, J.F.D.. Dating aeolian sediments using ESR Ti-Li center in quartz, TL and OSL-SAR: Dama Branca, study. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 23-23.

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  • IPEN-DOC 26015

    GONZALES-LORENZO, CARLOS; WATANABE, SHIGUEO; BUENO, CARMEN ; KODAIRA, SATOSHI; NASCIMENTO, LUANA. CaSiO3 polycrystal for neutron, proton and carbon detection. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 20-20.

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  • IPEN-DOC 26014

    VILLANI, D. ; DORES, D.S. das; SILVA, V.R. da; COSTA, Z.M. da; CAMPOS, L.L. . Er+Ag-doped phosphate glass as luminescent dosimeters. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 325-325.

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  • IPEN-DOC 26011

    SANTOS, W.S. ; NEVES, L.P. ; PERINI, A.P.; BELINATO, W.; CALDAS, L.V.E. . Evaluation of polymer gels using Monte Carlo simulations. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 80-80.

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  • IPEN-DOC 26010

    SILVA, EZEQUIEL da ; ASSEMANY, LADYJANE P.F. ; POTIENS, MARIA da P.A. . Performance evaluation of a cilindrical ionization chamber used in radiation protection measurements of diagnostic radiology clinical systems. In: RUBIO, MARCELO (Ed.); TIRAO, GERMAN (Ed.) INTERNATIONAL SYMPOSIUM ON RADIATION PHYSICS, 14th, October 7-11, 2018, Córdoba, Argentina. Abstract... Córdoba: Centro de Excelencia en Productos y Procesos, 2018. p. 60-60.

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  • IPEN-DOC 26009

    CASTRO, PEDRO A.A. de ; ZEZELL, DENISE M. ; MORAIS, MYCHEL R.P.T.; ZORN, TELMA M.. Semi quantitative evaluation of skin burn wound healing: ATR-FTIR study. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 42nd, 26-31 de maio, 2019, Aracaju, SE. Resumo... São Paulo: Sociedade Brasileira de Física, 2019.

    Abstract: The role of skin wound healing the biochemical mechanisms are still not fully understood and spectroscopy may shine some light on this information. The Fourier Transform Infrared spectroscopy coupled with Attenuated Total Re°ectance (ATR-FTIR) has been demonstrated potential to monitor the biomolecule activity upon biological samples. This work aims to evaluate the feasibility of using ATR-FTIR to discriminate burned skin throughout wound stages. Water vapor at 90±C was applied to the dorsum of Wistar rats resulting in standardized third-degree burns. Tissue samples were collected after 3±, 7±, 14± and 21 days post burn injury. For the acquisition of the spectra, 150 scans were averaged with a resolution of 4 cm¡1 and wavenumbers ranging from 4000 to 400 cm¡1. Analysis of the spectra was calculated using MATLABR°R2015a (MathWorks, Natick, MA) software. Fingerprint region (900 - 1800 cm¡1) and high wavenumber (2800 - 3000 cm¡1) of spectra were o®set-corrected and vector normalized. Area under the curve (AUC) of collagen (1236 cm¡1), amide II (1540 cm¡1), amide I (1632 cm¡1) and lipid (2852 cm¡1) of each group were performed by integration method. The FTIR results exhibit the high biochemical activity of the tissue in the 14o post burn injury when it is compared with control group which correspond to the stage when the new tissue formation is still ongoing. The lipid content decrease in the 21 day, which suggest that the metabolic activity and structural reorganization decrease as the wound healing progress. For future works, micro-FTIR imaging will be used spatially discriminate the bands.

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  • IPEN-DOC 26008

    AMARAL, MARCELLO M.; ARAUJO, JEANN C.R.; ANTUNES, ANDREA; MONTE, ADAMO F.G.; CARA, ANA C.B. de ; FREITAS, ANDERSON Z. de ; ZEZELL, DENISE M. . Phantom validation of optical attenuation coefficient estimation model with depth resolution for Optical Coherence Tomography. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 42nd, 26-31 de maio, 2019, Aracaju, SE. Resumo... São Paulo: Sociedade Brasileira de Física, 2019.

    Abstract: Optical Coherence Tomography (OCT) has been used for imaging and analyzes over a broad number of applications.[1-3] Besides its use for morphological analysis [3] the OCT signal has been used to determine the optical attenuation coe±cient of biological samples for classi¯cation and diagnostic proposes. [1,2] The most common model for estimating the optical attenuation coe±cient based on OCT signal relies on the Lambert- Beers law. It usually assumes a constant attenuation coe±cient value over the image range or over a selected range, losing the in-depth resolution on OCT. Previous published work on literature developed a model to esti- mate the attenuation coe±cient with depth resolution [4], however it assumes that the light is totally attenuated within the image depth range failing for membrane like samples. We present a model that, using the tissue sample transmittance as input, remove this limitation and to estimate the depth-resolved optical attenuation coe±cient. This method allows us to obtain an image of tissue optical properties instead of that from intensity contrast, guiding diagnosis and tissues di®erentiation, extending its application from thin to tick samples. The performance of our method was tested with the assistance of a home built single layer and multi-layer phantoms ( 100¹m each layer). These optical phantoms are composed of a substrate polydimethylsiloxane (PDMS), Zinc- Phthalocyanine (ZnPc) dye as chromophores, and TiO2 as scattering agent. The optical attenuation coe±cient ranges from 0:9 to 2:32 mm¡1, measured using an integrating sphere followed by the Inverse Adding Doubling processing technique. We show that the estimated depth-resolved attenuation coe±cient recovers the reference values, with a error deviation of 7 %.

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  • IPEN-DOC 26007

    LIMA, CASSIO ; BYRNE, HUGH; CORREA, LUCIANA; ZEZELL, DENISE . Molecular pathology via infrared spectral imaging for skin cancer diagnosis. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 42nd, 26-31 de maio, 2019, Aracaju, SE. Resumo... São Paulo: Sociedade Brasileira de Física, 2019.

    Abstract: Fourier Transform Infrared (FTIR) spectroscopy is a rapid and label-free analytical technique that provide information about the overall biochemical pro¯le of biological samples based on the vibrations of its basic molecular components (carbohydrates, proteins, lipids and nucleic acids) that are infrared active. The potential biomedical applications of FTIR spectroscopy as a tool for cancer diagnosis have been well demonstrated over the last years. However, most studies have focused on evaluate the diagnostic ability of FTIR by comparing healthy tissue to cancers on advanced stage and few studies have centered on evaluating the early stages of cancer. Thus, the present study aims to demonstrate the ability of FTIR spectroscopy to discriminate healthy skin from advanced skin cancer (squamous cell carcinoma) as well as from early stages of malignancy using the information retained by spectral data. Cutaneous neoplastic lesions were chemically-induced on Swiss mice using a well-stablished two-stage carcinogenesis protocol. Healthy tissue was collected from animals non-exposed to chemicals and di®erent disease stages were obtained by varying the exposure time of animals to carcinogenenic factors. Tissue sections were obtained from formalin-¯xed para±n-embedded (FFPE) and placed on calcium °uoride substrates. FTIR hyperspectral images were acquired in transmission mode over mid-infrared spectral region and compared using Principal Components Analysis (PCA) associated to Linear Discriminant Analysis (PC-LDA). Satisfactory data discrimination (accuracy, sensitivity and speci¯city) was achieved by PC-LDA and the variables responsible by classi¯cation were evaluated in order to assess the spectral changes of skin components during the transition of healthy into diseased state. Our ¯ndings demonstrate the potential of FTIR spectroscopy not only for skin cancer diagnosis, but also to evaluate the biochemical events triggered by cancer without requiring laborious and time-consuming procedures or expensive labeled probes as biomarkers.

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  • IPEN-DOC 26006

    PEREIRA, DAISA L. ; CASTRO, PEDRO A.A. ; GOMES, GABRIELA V. ; ZAMATARO, CLAUDIA B. ; ZEZELL, DENISE M. ; RIBEIRO, HENRIQUE B.; MATOS, CHRISTIANO J.S.; ANA, PATRICIA A.. Heat-induced depth of Nd:YAG laser irradiation in biological hard tissues. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 42nd, 26-31 de maio, 2019, Aracaju, SE. Resumo... São Paulo: Sociedade Brasileira de Física, 2019.

    Abstract: Confocal Raman spectroscopy is a non-destructive and non-invasive technique which provides surface Raman spectra and depth images of biological structures contactless with the sample, with no use of ionizing radiation to penetrate in the sample under analysis. These characteristics allow its experimental use without any side e®ects to the sample. The depth images are obtained by Raman microscopy and are related to the characteristics of the tissues. This study aims to characterize irradiated hard tissues and correlate the depth reached by the heat of the laser irradiation with the obtained images. For this, thirty 8 mm2 blocks of bovine enamel and bovine root dentin, were randomized into 6 groups: G1- enamel untreated; G2- enamel irradiated with Nd:YAG micropulsed laser (1064 nm, 10 Hz- Lares Research R°) using a coal paste as photoabsorber; G3- enamel irradiated with Nd:YAG nanopulsed laser (1064 nm, 20 Hz, Brilliant, Quantel Laser) using a coal paste as photoabsorber; G4-G6 (bovine root dentin in the same conditions of treatment of G1-G3). The measurements were performed in three di®erent depth regions of the cubic shaped samples: region A- left corner above of the sample, region B- middle of the sample and Region C- right corner below of the sample. The area under the phosphate, carbonate, amide I, II, and III bands were calculated. The Raman spectra of the Nd:YAG irradiated samples detected a reduction in all the organic components of the enamel after laser irradiation. Previous studies of our group demonstrated that di®erences in carbonate substitution in the apatite lattice are related to the apatite instability and demineralization susceptibility. Considering that carbonate free apatite is less susceptible to acid attack, the results of this study suggest that Nd:YAG lased enamel can be more resistant to caries, in a direct correlation to the thickness of the treated area. It was found that for micropulsed Nd:YAG laser, the heat induced depth was 10 § 2 ¹m and for nanopulsed laser the heat induced depth was 8 § 3 ¹m. So, it is possible to correlate the heat penetration depth of the laser irradiation with the images obtained by the confocal Raman.

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  • IPEN-DOC 26005

    ZAMATARO, CLAUDIA B. ; KUCHAR, NIELSEN G. ; SCAPIN, MARCOS A. ; ZANINI, NATHALIA ; CASTRO, PEDRO ; RABELO, THAIS F. ; JUVINO, AMANDA C. ; ZEZELL, DENISE . Calcium analysis from gamma sterilized human dentin and enamel. In: ENCONTRO DE OUTONO DA SOCIEDADE BRASILEIRA DE FÍSICA, 42nd, 26-31 de maio, 2019, Aracaju, SE. Resumo... São Paulo: Sociedade Brasileira de Física, 2019.

    Abstract: Gamma radiation changes the patients0 oral cavity undergoing radiotherapy. Alterations cause an unsaturated environment of calcium and phosphate into the oral cavity. After approval of the Ethics Committee, 20 hu- man teeth were sectioned to obtain 20 human enamel and 20 dentin samples, polished plane. Samples were randomized in the irradiated group and control group (untreated). Then, the treatment group was irradiated with 25:0 kGy at the 60Co multipurpose irradiator. After the gamma irradiation, Fourier Transformed Infrared Spectroscopy (FTIR), percentage of surface microhardness loss (%SMHL) and Scanning Electron Microscopy (SEM) were performed. At the end, acidic biopsies were performed to quantify the concentration of calcium present in the samples. FTIR showed that the molecular structure of HA of the enamel is similar to the non- irradiated, with no formation or loss of molecular compounds occurring. X-ray °uorescence at enamel samples was performed. Microscopic morphological analysis did not shown signi¯cant di®erences. Surface microhardness is an indirect indicator of the mineral content of the samples. The mean obtained was 258:2 (38:8) KHN within the hardness spectrum of the healthy natural enamel. The compounds present in the samples and the values of the ratios of Calcium and Phosphate oxides and relation between the elements Calcium and Phosphorus. The ratio of the most stable oxides shows a variation with linear correlation. In the enamel, the ratio (Ca/P) shows a change in the elemental content with linear correlation (R2 = 1). These ¯ndings lead us to a new hypothesis of behaviour of the HA crystal versus gamma irradiation. On the other hand for the irradiated dentin, the Knoop hardness number was within the range of the spectrum similar to that of natural dentin of human origin. X-ray °uorescence shows that irradiated dentin has great similarity with natural dentin from the point of view of chemical composition. SEM analyses showed that there was no thermal damage or interprismatic morpho- logical changes in the hydroxyapatite structure of human dental dentin outside the buccal environment when using doses of gamma irradiation up to 25 kGy.

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  • IPEN-DOC 26004

    OLIVEIRA, R.R. ; FUJIMOTO, T.G. ; MUCCILLO, E.N.S. . Estudo da densificação, estrutura e microestrutura do SrTiO3 contendo praseodímio. In: CONGRESSO BRASILEIRO DE CERÂMICA, 63rd, 4-7 de agosto, 2019, Bonito, MS. Resumo... 2019.

    Abstract: Materiais com estrutura do tipo perovsquita apresentam interessantes propriedades físicas que podem ser escritas em termos de distorções estruturais associadas a mudanças na composição química juntamente com os defeitos existentes na rede cristalina. Isso permite uma ampla faixa de aplicação em dispositivos eletrônicos tais como: supercacitores; dispositivos para armazenamento de energia; atuadores piezoelétricos; dentre outras. Particularmente, os materiais baseados em titanato de estrôncio (STO) tem sido intensamente estudados, sobretudo sua estrutura e microestrutura. A estrutura cristalina pode ser alterada por meio de substituições químicas com a introdução de aditivos. Neste trabalho, foi realizado o estudo estrutural e microestrutural do STO contendo diferentes teores de praseodímio. As amostras foram preparadas mediante mistura de óxidos convencional, partindo do STO e Pr6O11 comerciais. As amostras de STO contendo 0,025; 0,050; 0,075 e 1% mol de Pr foram conformadas por compactação uniaxial e isostática e sinterizadas à 1500 ºC durante 6 horas. A caracterização das amostras sinterizadas foi realizada mediante densidade aparente pelo método de Arquimedes, microscopia eletrônica de varredura (MEV) para o estudo da morfologia superficial (em amostras polidas) e difração de raios X para determinação da estrutura por meio de refinamento pelo método de Rietvield. Os resultados mostram que as amostras apresentam densidade próxima à teórica (95%), com exceção da contendo 1% mol do aditivo (83%). As micrografias obtidas por MEV mostram que houve um tênue aumento no tamanho médio de grãos de 28 m em STO para 30 m nas amostras contendo praseodímio. Nos parâmetros de rede obtidos pelo refinamento dos padrões de difração de raios X foi observado que as amostras foram cristalizadas no sistema cúbico e não possuem alterações significativas nas diferentes proporções de aditivos variando de 3,904 à 3,906 Å.

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  • IPEN-DOC 26003

    MUCCILLO, E.N.S. ; FUJIMOTO, T.G. ; SOUZA, J.P. . Avaliação da microestrutura do SrTiO3 comercial e obtido por reação em estado sólido. In: CONGRESSO BRASILEIRO DE CERÂMICA, 63rd, 4-7 de agosto, 2019, Bonito, MS. Resumo... 2019.

    Abstract: Materiais com estrutura do tipo perovskita tem diversas aplicações na indústria eletro-eletrônica, como por exemplo, em dispositivos eletrônicos, capacitores, ou transdutores piezoelétricos. Dentre os principais materiais utilizados com esse tipo de estrutura que vem sendo amplamente estudado destaca-se o titanato de estrôncio. A microestrutura deste tipo de perovskita é essencial para obtenção das propriedades de interesse para estas aplicações. Portanto, neste trabalho foi realizado o estudo da microestrutura do titanato de estrôncio por meio de microscopia eletrônica de varredura e de força atômica. As amostras foram preparadas utilizando o titanato de estrôncio obtido por meio de reação em estado sólido e comercial. Os compactos cerâmicos foram sinterizados a 1500ºC por 6 h de patamar. As amostras foram caracterizadas por meio de densidade, microscopia eletrônica de varredura, espectroscopia de energia dispersiva (EDS) e microscopia de força atômica. Os resultados mostraram que as amostras sintetizadas apresentaram regiões com forma triangular onde foi identificada uma alta concentração de Sr por meio de EDS. A amostra produzida a partir do material comercial apresentou grãos heterogêneos e através do mapa de adesão foi possível observar texturas diferentes dos grãos. As amostras possuem densidades acima de 99% da densidade teórica.

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  • IPEN-DOC 26002

    FERREIRA, L.A.S. ; REIS, S.L. ; MUCCILLO, E.N.S. . Estabilização de fase e microestrutura da zircônia-céria obtida por reação em estado sólido. In: CONGRESSO BRASILEIRO DE CERÂMICA, 63rd, 4-7 de agosto, 2019, Bonito, MS. Resumo... 2019.

    Abstract: Materiais cerâmicos à base de zircônia estabilizada na fase tetragonal têm sido extensivamente estudados e propostos para diversas aplicações devido suas destacadas propriedades termomecânicas. A zircônia contendo 12 mol% em céria (12Ce-TZP) possui estrutura tetragonal, alta resistência à fratura e estabilidade térmica. Este trabalho tem como objetivo verificar o efeito da sinterização na estabilização da fase tetragonal e na microestrutura da 12Ce-TZP preparada por reação em estado sólido. As amostras de 12Ce-TZP foram preparadas pelo método de mistura dos óxidos reagentes seguida de sinterização em diversas temperaturas. As fases cristalinas, densificação e microestrutura foram analisadas por difração de raios X, medidas de densidade hidrostática e microscopia eletrônica de varredura, respectivamente. O teor de fase monoclínica foi quantificado utilizando o método dos polimorfos. Amostras com fase única tetragonal foram obtidas para sinterizações a 1400 °C e densidades próximas à teórica (> 99%) para amostras sinterizadas a 1500 °C.

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  • IPEN-DOC 26001

    GROSSO, R.L. ; MUCHE, D.N.F.; CASTRO, R.H.R.; MUCCILLO, E.N.S. ; DILLON, S.. Testes mecânicos de nano-compressão por MET in-situ em zircônia estabilizada. In: CONGRESSO BRASILEIRO DE CERÂMICA, 63rd, 4-7 de agosto, 2019, Bonito, MS. Resumo... 2019.

    Abstract: Zircônia-escândia (ScZ) possui grande interesse tecnológico para aplicação como eletrólito sólido devido a sua maior condutividade iônica entre os materiais à base de zircônia. No entanto, as propriedades mecânicas de ScZ são pouco conhecidas, principalmente, devido à instabilidade de fase, que limita a aplicação desse material. Considerando que a estrutura cúbica tipo fluorita é dependente do tamanho dos grãos e pode ser estabilizada em nanoescala, nesse trabalho, foram investigadas as propriedades mecânicas de amostras densas de ScZ nanoestruturadas. Amostras ScZ foram obtidas por sinterização assistida por campo elétrico, pelo método, recentemente proposto, que utiliza punções deformáveis. Esse método de sinterização inibe o crescimento de grãos devido às baixas temperaturas utilizadas e elimina a porosidade residual devido à aplicação de alta pressão. Amostras de ZrO2 contendo teor molar de 10% de Sc2O3 foram sintetizadas pelo método de coprecipitação de hidróxidos, calcinadas e sinterizadas em baixas temperaturas (700 a 860 °C) e elevadas pressões (1,4 e 2 GPa). Foram produzidas amostras cúbicas policristalinas com tamanho médio de grãos entre 8 e 17 nm. Testes mecânicos de compressão foram realizados por microscopia eletrônica de transmissão in situ em nanopilares de seção transversal quadrada preparados por feixe de íons focalizado. As propriedades mecânicas foram avaliadas em função do tamanho médio de grãos. Foi observada uma considerável melhoria nas propriedades mecânicas em amostras nanoestruturadas de ScZ. O limite de escoamento aumentou de 1,9 para 4,9 GPa com a diminuição do tamanho médio de grãos de 50 para 13 nm. Os valores de limite de escoamento seguem a relação de Hall-Petch para amostras com tamanho médio de grãos de até 13 nm, onde ocorre a inversão na relação de Hall-Petch.

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  • IPEN-DOC 26000

    REIS, S.L. ; CARVALHO, S.G.M. ; MUCCILLO, E.N.S. ; MUCCILLO, R. . Densificação de céria-samária por meio de sinterização sem pressão assistida por campo elétrico AC. In: CONGRESSO BRASILEIRO DE CERÂMICA, 63rd, 4-7 de agosto, 2019, Bonito, MS. Resumo... 2019.

    Abstract: A solução sólida céria-samária é uma das principais candidatas para aplicação como eletrólito sólido em células a combustível de óxido sólido, devido sua alta condutividade iônica em temperaturas intermediárias de operação (500-750 °C). Um dos problemas ainda não solucionados é sua relativamente baixa sinterabilidade. Altas temperaturas de sinterização, em geral acima de 1500 °C, são necessárias para obter densificação com impermeabilização a gases (> 92% da densidade teórica). Em altas temperaturas pode ocorrer redução de Ce4+ para Ce3+, com consequente aumento na condutividade eletrônica. No entanto, a utilização de métodos de sinterização não convencionais como a sinterização sem pressão assistida por campo elétrico é uma das estratégias para diminuir a temperatura de sinterização e otimizar as propriedades. Este trabalho tem como objetivo avaliar os efeitos do método de sinterização isotérmica assistida por campo elétrico AC durante o patamar em uma temperatura fixa. Foram realizados experimentos variando campo elétrico, tempo de aplicação do campo e limite de corrente elétrica. Os resultados mostraram que é possível densificar a céria-samária em temperaturas inferiores às convencionais por meio de sinterização sem pressão assistida por campo elétrico. O aumento do valor do campo elétrico promoveu diminuição nos valores de resistividade intragranular e intergranular. O aumento na temperatura de aplicação do campo elétrico resultou em amostras com condutividade elétrica maior em relação à amostra sinterizada convencionalmente em 1500 °C/2 h.

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  • IPEN-DOC 25999

    REIS, S.L. ; MUCCILLO, E.N. . Influence of calcium addition on the electrical conductivity of samarium doped ceria. In: INTERNATIONAL CONFERENCE & EXPOSITION ON ADVANCED CERAMICS AND COMPOSITES, 42nd, January 21-26, 2018, Daytona Beach, Florida, USA. Abstract... Westerville, OH, USA: The American Ceramic Society, 2018. p. 97-97.

    Abstract: Ceria-based ceramics have been proposed to be used as solid electrolyte in solid oxide fuel cells operating at intermediate (500-750°C) temperatures, due to their high ionic conductivity. Samarium ion is recognized as one of the most reliable dopants for cerium oxide because of its lower association energy with oxygen vacancies. One challenge posed to ceria-based solid electrolytes is how to improve sinterability, avoiding high temperatures to attain good densification. Thermal treatments at high temperatures may reduce Ce4+ to Ce3+, favoring electron transport and generation of micropores in the sintered electrolyte. Introduction of a second additive is a usual approach to overcome these constraints. In this work calcium ion was chosen as the second additive. Sm0.2-xCaxCe0.8O1.9-x/2 compositions, with x = 0, 0.025, 0.05, 0.1, 0.15 and 0.2, were prepared by solid-state reaction, and the influence of the additive content on densification and ionic conductivity was investigated. All compositions were found to have cubic fluorite-type structure. The optimal composition was Sm0.175Ca0.025Ce0.8O1.888, which showed a relative density of 97%, single phase and higher ionic conductivity than the Sm0.2Ce0.8O1.9 parent electrolyte.

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  • IPEN-DOC 25998

    SOUZA, J.P. ; MUCCILLO, E.N. . Ionic conductivity and phase stabilization in zirconia-scandia-europia. In: INTERNATIONAL CONFERENCE & EXPOSITION ON ADVANCED CERAMICS AND COMPOSITES, 42nd, January 21-26, 2018, Daytona Beach, Florida, USA. Abstract... Westerville, OH, USA: The American Ceramic Society, 2018. p. 97-97.

    Abstract: Zirconia-8 mol% yttria is widely used as electrolyte in solid oxide fuel cells, due to its high ionic conductivity and good mechanical and chemical properties. Nevertheless, scandia-stabilized zirconia is recognized as exhibiting the highest ionic conductivity among zirconia-based solid electrolytes. Stabilization of the high symmetry and high ionic conductivity cubic phase in this system is non-trivial. Introduction of a second additive (or dopant) is a usual strategy to overcome that constraint. In this work, europium oxide has been added to 10 mol% scandia-stabilized zirconia (10ScSZ) aiming full stabilization of the cubic structure at room temperature. The influence of europia addition (up to 1.25 mol%) on phase stabilization and ionic conductivity of 10ScSZ was investigated by differential scanning calorimetry and impedance spectroscopy. The higher is the fraction of europia into solid solution the lower is the temperature of the endothermic event due to phase transition. The cubic phase is fully stabilized at room temperature for 1 mol% europia addition. The grain and total ionic conductivity show typical Arrhenius behavior. The magnitude of the total conductivity increases with increasing europia addition.

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  • IPEN-DOC 25997

    MUCCILLO, R. ; MUCCILLO, E.N. . Non-conventional joining of a ceramic solid oxide fuel cell to a metallic interconnect. In: INTERNATIONAL CONFERENCE & EXPOSITION ON ADVANCED CERAMICS AND COMPOSITES, 42nd, January 21-26, 2018, Daytona Beach, Florida, USA. Abstract... Westerville, OH, USA: The American Ceramic Society, 2018. p. 208-208.

    Abstract: Co-generation of energy (heat and electric power) with ceramic solid oxide fuel cells requires consolidation of anode-electrolyte- cathode single cells with a dense electrolyte and porous anode and cathode. The consolidation is usually achieved by sintering the three-layer single cells according to special procedures to produce flat square shape cells. Non-conventional consolidation of several ceramic materials used in energy-conversion devices has been done with success in several ceramic materials by electric field-assisted pressureless sintering, producing porous or dense components. The same approach has been tried in a flat single solid oxide fuel cell with yttria-stabilized zirconia solid electrolyte, lanthanum strontium manganite cathode and yttria-stabilized zirconia/nickel oxide anode with promising results, opening new routes for future low cost production of these devices. There is still a challenge in using that technique for joining ceramic single cells to metallic interconnector, one of the research areas of Dr. Mrityunjay Singh. Our efforts now are directed to carry out experiments aiming the joining of ceramic single cells to metallic interconnects by application of electric fields.

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  • IPEN-DOC 25996

    DAMATTO, SANDRA R. ; MADUAR, MARCELO F. ; LEONARDO, LUCIO; BORGES, LARISSA R.; OLIVEIRA, GABRIEL F.M.; SILVA, SANDRA M.C.S. da. Radioatividade natural em castanhas. In: CONGRESSO MULTIPROFISSIONAL DO CENTRO UNIVERSITÁRIO SÃO CAMILO, 3rd, 9-10 de novembro, 2018, São Paulo, SP. Resumo... São Paulo: Centro Universitário São Camilo, 2018. p. 297-297.

    Abstract: INTRODUÇÃO: A radioatividade natural está presente em todos os compartimentos do ecossistema terrestre, como ar, solo, água, alimentos e no ser humano, originada dos radionuclídeos naturais encontrados na crosta terrestre. Os radionuclídeos naturais mais abundantes na natureza são os das séries de decaimento radioativo do 238U e 232Th, e 40K. A radioatividade natural chega até o homem pela cadeia alimentar, por meio dos alimentos vegetais e animais, fazendo com que todos os alimentos possuam diferentes concentrações dos radionuclídeos naturais. Vários tipos de castanhas são utilizadas em dietas e, dentre este grupo de alimentos, destaca-se a castanha-do-brasil, por ser um alimento que possui as maiores concentrações de atividade dos radionuclídeos naturais 226Ra, 228Ra e 40K. OBJETIVO: Determinar as concentrações de atividade dos radionuclídeos naturais 40K, 226Ra, 228Ra e 228Th em castanhas consumidas pela população brasileira: castanha-do-brasil, coco, pecã brasileira, castanha de baru, castanha de caju e pinhão cru e cozido. MATERIAIS E MÉTODOS: A determinação dos radionuclídeos naturais foi realizada por espectrometria gama, utilizando um detector de germânio hiperpuro (HPGe) associado a um sistema eletrônico e tempo de medida de 250.000 s. RESULTADOS: As maiores concentrações de atividade de 226Ra foram obtidas na castanha-do-brasil e de 40K na amostra de coco. Somente na amostra de castanha-do-brasil foram determinadas as concentrações de atividade de 228Th e 228Ra. Pode-se observar que a amostra de pinhão cozido apresentou menores valores de concentração de atividade para os radionuclídeos determinados. CONCLUSÃO: No presente trabalho foram determinadas as concentrações de atividade dos radionuclídeos naturais 40K, 226Ra, 228Ra e 228Th em amostras das castanhas: castanha de baru, castanha de caju, castanha- do-brasil, coco, pecã brasileira e pinhão, cru e cozido. Os valores determinados de 40K e 226Ra para a castanha-do-brasil encontraram-se de acordo com a literatura, e as determinações das concentrações de atividade nas outras amostras contribuíram para um levantamento de banco de dados para cálculo de dose devido ao consumo das demais castanhas.

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A pesquisa apresentará melhor resultado selecionando um dos filtros disponíveis em Navegar

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A opção Busca avançada utiliza os conectores da lógica boleana, é o melhor recurso para combinar chaves de busca e obter documentos relevantes à sua pesquisa, utilize os filtros apresentados na caixa de seleção para refinar o resultado de busca. Pode-se adicionar vários filtros a uma mesma busca.

Exemplo:

Buscar os artigos apresentados em um evento internacional de 2015, sobre loss of coolant, do autor Maprelian.

Autor: Maprelian

Título: loss of coolant

Tipo de publicação: Texto completo de evento

Ano de publicação: 2015

Para indexação dos documentos é utilizado o Thesaurus do INIS, especializado na área nuclear e utilizado em todos os países membros da International Atomic Energy Agency – IAEA , por esse motivo, utilize os termos de busca de assunto em inglês; isto não exclui a busca livre por palavras, apenas o resultado pode não ser tão relevante ou pertinente.

95% do RD apresenta o texto completo do documento com livre acesso, para aqueles que apresentam o significa que e o documento está sujeito as leis de direitos autorais, solicita-se nesses casos contatar a Biblioteca do IPEN, bibl@ipen.br .

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O RD disponibiliza um quadro estatístico de produtividade, onde é possível visualizar o número dos trabalhos agrupados por tipo de coleção, a medida que estão sendo depositados no RD.

Na página inicial nas referências são sinalizados todos os autores IPEN, ao clicar nesse símbolo será aberta uma nova página correspondente à aquele autor – trata-se da página do pesquisador.

Na página do pesquisador, é possível verificar, as variações do nome, a relação de todos os trabalhos com texto completo bem como um quadro resumo numérico; há links para o Currículo Lattes e o Google Acadêmico ( quando esse for informado).

ATENÇÃO!

ESTE TEXTO "AJUDA" ESTÁ SUJEITO A ATUALIZAÇÕES CONSTANTES, A MEDIDA QUE NOVAS FUNCIONALIDADES E RECURSOS DE BUSCA FOREM SENDO DESENVOLVIDOS PELAS EQUIPES DA BIBLIOTECA E DA INFORMÁTICA.

O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.

A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.

1. Portaria IPEN-CNEN/SP nº 387, que estabeleceu os princípios que nortearam a criação do RDI, clique aqui.


2. A experiência do Instituto de Pesquisas Energéticas e Nucleares (IPEN-CNEN/SP) na criação de um Repositório Digital Institucional – RDI, clique aqui.