Beta-adrenergic blockade decreases the neuroimmune changes in mice induced by cohabitation with an ehrlich tumor-bearing cage mate
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2017
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Neuroimmunomodulation
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Objectives: Cohabitation with Ehrlich tumor-bearing (ETB)
mice induced behavioral, neurochemical, hormonal, and immune
effects in the conspecifics as a consequence of stressinduced
activation of the sympathetic nervous system (SNS)
with catecholamine release. In the current study, the nonspecific
β-AR blocker d,l -propranolol and the specific β 2 -AR
blocker ICI-118.551 were employed as pharmacological
tools to assess the extent to which catecholamines participated
in the effects induced by cohabitation with ETB mice.
Methods: Two experiments were performed, 1 with d,l -propranolol
treatment and the other with ICI-118.551. One
mouse in the experimental group was called the “companion of the sick partner” (CSP) since it was forced to live in the
same cage with 2 (experiment 1) or 1 (experiment 2) cage
mate that had been i.p. injected with 5 × 10 6 Ehrlich tumor
cells. Results: The d,l -propranolol treatment, but not the ICI-
118.551 treatment, attenuated the effects of cohabitation
with 2 ETB mice on both open-field behavior and the hypothalamic
levels and turnover rate of norepinephrine. The 2
β-AR blockers were unable to change the serum corticosterone
levels and adrenal weights of the CSP mice; however,
these drugs abrogated the effects of cohabitation on neutrophil
oxidative burst and phagocytosis. Finally, an increase in
the 5-HT turnover rate was observed in the olfactory bulb of
CSP mice compared to their respective controls, an effect
that was not modified by β-AR blockade. Conclusion: These
results confirm and strengthen our hypothesis that the SNS
is involved in the effects induced by cohabitation with ETB
mice and point towards β 2 -AR participation in the immune
effects analyzed.
Como referenciar
MARGATHO, RAFAEL O.; MASSOCO, CRISTINA de O.; CALEFI, ATILIO S.; CRUZ, DANIEL S.G.; SANDINI, THAISA M.; ALVES, GLAUCIE J.; FLORIO, JORGE C.; PALERMO-NETO, JOAO. Beta-adrenergic blockade decreases the neuroimmune changes in mice induced by cohabitation with an ehrlich tumor-bearing cage mate. Neuroimmunomodulation, v. 24, n. 1, p. 40-53, 2017. DOI: 10.1159/000477938. Disponível em: http://repositorio.ipen.br/handle/123456789/28448. Acesso em: 20 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.