Effects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS)
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2018
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Physica B: Condensed Matter
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Cancer is still a major public health problem. Leaving detection of early stages of tumors and other issues aside,
minimizing unwarranted side effects, for example after clinical usage of a liposomal anticancer drug doxorubicin
(Dox) formulation, is an unmet clinical problem and the focus of many studies. Using compounds typically used in
the preparation of food and/or cosmetics to prepare drug carrier systems, we observed that sodium tetradecyl
sulfate (STS) containing and soybean-oil based carriers are more efficient in reducing the viability of HeLa cells
tumor cells in comparison to their respective counterparts. Here, we probe the doxorubicin (Dox) loading on
structural properties of either soybean oil or coconut oil (Mygliol 812) formulations. Small angle neutron scattering
(SANS) assays were performed using V16 instrument at Helmholtz-Zentrum Berlin (HZB) at 25, 37 and
40 C with two or 11m distance between detector and sample to assess a wide range in scattering vector Q.
Combined with previous measurement using small angle X-ray scattering (SAXS), our results show that the Dox
has different influence in the surface structure of the solid lipid nanoparticles (SLN) and also affects the fractality
in the vesicle aggregates when the concentration of the drug is altered, for Mygliol and soybean oil SLN drug
delivery carrier systems.
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YOKAICHIYA, FABIANO; SCHMIDT, CHRISTIAN; STORSBERG, JOACHIM; VOLLRATH, MONT K.; ARAUJO, DANIELE R. de; KENT, BEN; CLEMENS, DANIEL; WINGERT, FRIEDRICH; FRANCO, MARGARETH K.K.D. Effects of doxorubicin on the structural and morphological characterization of solid lipid nanoparticles (SLN) using small angle neutron scattering (SANS) and small angle X-ray scattering (SAXS). Physica B: Condensed Matter, v. 551, p. 191-196, 2018. DOI: 10.1016/j.physb.2017.12.036. Disponível em: http://repositorio.ipen.br/handle/123456789/28506. Acesso em: 23 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.