Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice
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2018
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Work-exacerbated asthma (WEA) is defined as preexisting asthma that worsens with exposure to
irritants [e.g., chlorine (Cl2) derivatives] in the workplace. The maximum allowable concentration in the
workplace of Cl2 exposure is 3 mg/ m3 (described in OSHA). We investigated in an experimental asthma
model in mice the effects of a single exposure to a sodium hypochlorite dose with this allowed chlorine
concentration and a tenfold higher dose. Acute chlorine exposure at 3.3 mg/m3 in the OVA-sensitized
group increased eosinophils in the peribronquial infiltrate, cytokine production, nasal mucus production
and the number of iNOS positive cells in the distal lung compared to only sensitized mice. The exposure
to a higher dose of 33.3 mg/m3 in the OVA-sensitized group resulted in an increase in respiratory
system elastance, in the total and differential numbers of inflammatory cells in bronchoalveolar lavage
fluid, IL-4, IL-5, and IL-17 in the lungs, eosinophils in peribronquial infiltrate and mucus content in
nasal compared to non-exposed and sensitized animals. In this asthma model, chorine exposures at
an allowable dose, contributed to the potentiation of Th2 responses. The functional alterations were
associated with increased iNOS and ROCK-2 activation in the distal lung.
Como referenciar
GENARO, ISABELLA S. de; ALMEIDA, FRANCINE M. de; HIZUME-KUNZLER, DEBORAH C.; MORIYA, HENRIQUE T.; SILVA, RONALDO A.; CRUZ, JOAO C.G.; LOPES, RENAN B.; RIGHETTI, RENATO F.; VIEIRA, RODOLFO de P.; SAIKI, MITIKO; MARTINS, MILTON A.; TIBERIO, IOLANDA de F.L.C.; ARANTES-COSTA, FERNANDA M.; SARAIVA-ROMANHOLO, BEATRIZ M. Low dose of chlorine exposure exacerbates nasal and pulmonary allergic inflammation in mice. Scientific Reports, v. 8, n. 12636, 2018. DOI: 10.1038/s41598-018-30851-6. Disponível em: http://repositorio.ipen.br/handle/123456789/29306. Acesso em: 18 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.