Porphyrins are increased in the faeces of patients with prostate cancer
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2018
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Background: Experimental models of prostate cancer have demonstrated increased levels of protoporphyrin IX
(PpIX) in the blood and faeces of mice. Hence, the quantification of these autofluorescent molecules could be
hypothesized to be a potential marker for this type of tumour. In this case-control study, the autofluorescence of
porphyrins in human faeces from patients with prostate cancer and control subjects was analysed using
fluorescence spectroscopy.
Methods: First, 3 mL of analytical-grade acetone was added to 0.3 g of faeces, and the mixture was macerated and
centrifuged at 4000 rpm for 15 min. The supernatant was analysed spectroscopically. The emission spectra from 550
to 750 nm were obtained by exciting the samples at 405 nm.
Results: A significant difference between the samples from control and cancer subjects was established in the
spectral region of 670–675 nm (p = 0.000127), which corresponds to a significant increase in faecal porphyrins in
patients with cancer. There was no statistically significant correlation between PSA levels and faecal porphyrins.
Conclusion: In this preliminary study conducted in humans, the results show a simple and non-invasive method
to assess faecal porphyrins, which have the potential to function as a tumour biomarker in patients with prostate
cancer. This approach has improved sensitivity and specificity over PSA testing. Additional prospective studies with
larger sample sizes are required to validate these findings.
Como referenciar
GOTARDELO, DANIEL R.; COURROL, LILIA C.; BELLINI, MARIA H.; SILVA, FLAVIA R. de O.; SOARES, CARLOS R.J. Porphyrins are increased in the faeces of patients with prostate cancer: a casecontrol study. BMC Cancer, v. 18, n. 1090, 2018. DOI: 10.1186/s12885-018-5030-1. Disponível em: http://repositorio.ipen.br/handle/123456789/29403. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.