Synthesis and characterization of PVP/CaCO3-Ag blend hydrogel by gamma irradiation
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2019
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Characterization of Minerals, Metals, and Materials
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Chronic wounds are skin injuries with failed healing. They have become a
public health problem that affects more than 2% of the population and the presence of
bacteria resistances difficult of treatment. Pseudomonas aeruginosa is opportunist
pathogens and the treatment is difficult and requires a long period of treatment.
Hydrogels are structure polymeric tridimensional and biocompatible. They have been
used as a controlled delivery system for treatment of topic infection. Studies have
reported calcium carbonate and silver ion can improve the mechanical properties and
biocide activity of hydrogel. Here in this study, hydrogels loaded CaCO3-Ag were
prepared using poly (N-vinyl-2-pyrrolidone), poly (ethylene glycol), agar, calcium
carbonate, silver nitrate followed gamma irradiation with 25 kGy dose. The gel
fraction, behavior swelling and biocide action against P. aeruginosawas investigated.
The degree of swelling of the hydrogel loaded CaCO3-Ag was 12% higher than the
unloaded and exhibited antibacterial effects against P. aeruginosa and biofilm.
Como referenciar
ZAFALON, ANGELICA T.; JUVINO, VINICIUS dos S.; KOMATSU, LUIZ G.H.; PARRA, DUCLERC F.; LUGAO, ADEMAR; SAMUEL, TEMESGEN; RANGARI, VIJAYA. Synthesis and characterization of PVP/CaCO3-Ag blend hydrogel by gamma irradiation: study of drug delivery system and antimicrobial activity. In: LI, BOWEN (ed.); LI, JIAN (ed.); IKHMAYIES, SHADIA (ed.); ZHANG, MINGMING (ed.); KALAY, YUNUS E. (ed.); CARPENTER, JOHN S. (ed.); HWANG, JIANN-YANG (ed.); MONTEIRO, SERGIO N. (ed.); BAI, CHENGUANG (ed.); ESCOBEDO-DIAZ, JUAN P. (ed.); SPENA, PASQUALE R. (ed.); GOSWAMI, RAMASIS (ed.). Characterization of Minerals, Metals, and Materials. Cham, CZ, Switzerland: Springer Nature Switzerland AG, 2019. p. 255-265. (The Minerals, Metals & Materials Series). DOI: 10.1007/978-3-030-05749-7_26. Disponível em: http://repositorio.ipen.br/handle/123456789/29841. Acesso em: 23 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.