In loco retention effect of magnetic core mesoporous silica nanoparticles doped with trastuzumab as intralesional nanodrug for breast cancer
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2018
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Artificial Cells, Nanomedicine, and Biotechnology
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Breast cancer is women’s most common type of cancer, with a global rate of over 522,000 deaths per
year. One of the main problems related to breast cancer relies in the early detection, as the specialized
treatment. In this direction was developed, characterized and tested in vivo a smart delivery system,
based on radiolabelled magnetic core mesoporous silica doped with trastuzumab as intralesional nanodrug
for breast cancer imaging and possible therapy. The results showed that nanoparticles had a size
of 58.9 ± 8.1 nm, with specific surface area of 872 m2/g and pore volume of 0.85 cm3/g with a pore
diameter of 3.15 nm. The magnetic core mesoporous silica was efficiently labelled with 99mTc (97.5%
±0.8) and doped >98%. The cytotoxicity assay, demonstrated they are safe to use. The data were corroborated
with the IC50 result of: 829.6 mg ± 43.2. The biodistribution showed an uptake by the tumour
of 7.5% (systemic via) and 97.37% (intralesional) with less than 3% of these nanoparticles absorbed by
healthy tissues. In a period 6-h post-injection, no barrier delimited by the tumour was crossed, corroborating
the use as intralesional nanodrug.
Como referenciar
PORTILHO, FILIPE L.; PINTO, SUYENE R.; BARROS, ALINE O. da S. de; HELAL-NETO, EDWARD; SANTOS, SOFIA N. dos; BERNARDES, EMERSON S.; ILEM-OZDEMIR, DERYA; ASIKOGLU, MAKBULE; ALENCAR, LUCIANA M.R.; SANTOS, CLENILTON C. dos; RICCI-JUNIOR, EDUARDO; SANCENON, FELIX; MARTINEZ-MANEZ, RAMON; SANTOS-OLIVEIRA, RALPH. In loco retention effect of magnetic core mesoporous silica nanoparticles doped with trastuzumab as intralesional nanodrug for breast cancer. Artificial Cells, Nanomedicine, and Biotechnology, v. 46, p. S725-S733, 2018. S3. DOI: 10.1080/21691401.2018.1508030. Disponível em: http://repositorio.ipen.br/handle/123456789/29945. Acesso em: 19 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.