Dissolving microneedles with aminolevulinic acid for PDT
Carregando...
Data
Data de publicação:
2019
Autores IPEN
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
SÃO PAULO SCHOOL OF ADVANCED SCIENCE ON MODERN TOPICS IN BIOPHOTONICS
Exportar
Resumo
Photodynamic Therapy (PDT) is a therapeutic modality that has been applied mainly to skin cancer treatment. For
topical PDT, the photosensitizer (PS) precursors are usually applied in a cream form. Aminolevulinic Acid (ALA)
and its derivatives are the most common photosensitizer’s precursors used, allowing the Protoporphyrin IX (PpIX)
accumulation. One of the challenges in topical PDT for skin cancer is to increase the cream permeation to
improve the success rate and treat deeper lesions. Microneedles (MNs) are minimally invasive systems already
used for intradermal vaccination, delivery of systemic drugs such as antibiotics or hormones. In this study, we
prepared dissolving MNs using 5% ALA concentration and 20% of Gantrez AN-139 polymer. The patch has 361
pyramidal microneedles with 500 μm high. The tests of mechanic strength, dissolution, and stability of MNs were
encouraging to perform this study. Three healthy volunteers received the MNs patches on the forearm, and
optical coherence tomography (OCT) images were collected showing the induced microholes in the skin after the
MN removal. We compared the superficial PpIX formation of the dissolving MNs and the standard cream at 20%
concentration by a fluorescence spectroscopy system. The study showed that even in lower concentration, the
MNs were able to produce a similar amount of PpIX compared to the cream in the same incubation time. The
results were encouraging to perform an animal tumor model to support the understanding of the PDT.
Como referenciar
REQUENA, MICHELLE B.; PIRES, LAYLA; PERMANA, ANDI D.; FREITAS, ANDERSON Z. de; KURACHI, CRISTINA; SALVIO, ANA G.; DONNELLY, RYAN F.; BAGNATO, VANDERLEI S. Dissolving microneedles with aminolevulinic acid for PDT: a pilot study in human skin. In: SÃO PAULO SCHOOL OF ADVANCED SCIENCE ON MODERN TOPICS IN BIOPHOTONICS, March 20-29, 2019, São Carlos, SP. Abstract... p. 67-68. Disponível em: http://repositorio.ipen.br/handle/123456789/30197. Acesso em: 19 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.