Galectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane
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2019
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Galectin-3 (Gal-3) controls intercellular and cell-extracellular matrix interactions during immunological
responses. In chronic inflammation, Gal-3 is associated with fibrotic events, regulates B cell
differentiation and delays lupus progression. Gal-3 deficient mice (Lgals3−/−) have intense germinal
center formation and atypical plasma cell generation correlated to high levels IgG, IgE, and IgA. Here,
we used pristane (2,6,10,14-tetramethylpentadecane) to induce lupus-like syndrome in Lgals3−/− and
Lgals3+/+ BALB/c mice. Mesentery and peritoneal cells were monitored because promptly react to
pristane injected in the peritoneal cavity. For the first time, mesenteric tissues have been associated to
the pathogenesis of experimental lupus-like syndrome. In Lgals3+/+ pristane-induced mice, mesentery
was hallmarked by intense fibrogranulomatous reaction restricted to submesothelial regions and
organized niches containing macrophages and B lymphocytes and plasma cells. In contrast, Lgals3−/−
pristane-treated mice had diffuse mesenteric fibrosis affecting submesothelium and peripheral tissues,
atypical M1/M2 macrophage polarization and significant DLL1+ cells expansion, suggesting possible
involvement of Notch/Delta pathways in the disease. Early inflammatory reaction to pristane was
characterized by significant disturbances on monocyte recruitment, macrophage differentiation and
dendritic cell (DC) responses in the peritoneal cavity of pristane-induced Lgals3−/− mice. A correlative
analysis showed that mesenteric damages in the absence of Gal-3 were directly associated with severe
portal inflammation and hepatitis. In conclusion, it has suggested that Gal-3 orchestrates histological
organization in the mesentery and prevents lupoid hepatitis in experimental lupus-like syndrome by
controlling macrophage polarization, Notch signaling pathways and DC differentiation in mesenteric
structures.
Como referenciar
LEMOS, F.S.; PEREIRA, J.X.; CARVALHO, V.F.; BERNARDES, E.S.; CHAMMAS, R.; PEREIRA, T.M.; CARVALHO, R.S.; LUISETTO, R.; EL-CHEIKH, M.C.; CALIL-ELIAS, S.; OLIVEIRA, F.L. Galectin-3 orchestrates the histology of mesentery and protects liver during lupus-like syndrome induced by pristane. Scientific Reports, v. 9, 2019. DOI: 10.1038/s41598-019-50564-8. Disponível em: http://repositorio.ipen.br/handle/123456789/30432. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.