Nitric oxide-loaded chitosan nanoparticles as an innovative antileishmanial platform
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2019
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Nitric Oxide
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Leishmaniasis is a neglected tropical disease that demands for new therapeutic strategies due to adverse side
effects and resistance development promoted by current drugs. Nitric oxide (NO)-donors show potential to kill
Leishmania spp. but their use is limited because of their instability. In this work, we synthesize, characterize, and
encapsulate S-nitroso-mercaptosuccinic acid into chitosan nanoparticles (NONPs) and investigate their activity
on promastigotes and intracellular amastigotes of Leishmania (Leishmania) amazonensis. Cytotoxicity on macrophages
was also evaluated. We verified that NONPs reduced both forms of the parasite in a single treatment.
We also noticed reduction of parasitophorous vacuoles as an evidence of inhibition of parasite growth and
resolution of infection. No substantial cytotoxicity was detected on macrophages. NONPs were able to provide a
sustained parasite killing for both L. (L.) amazonensis infective stages with no toxicity on macrophages, representing
a promising nanoplatform for cutaneous leishmaniasis.
Como referenciar
CABRAL, FERNANDA V.; PELEGRINO, MILENA T.; SAUTER, ISMAEL P.; SEABRA, AMEDEA B.; CORTEZ, MAURO; RIBEIRO, MARTHA S. Nitric oxide-loaded chitosan nanoparticles as an innovative antileishmanial platform. Nitric Oxide, v. 93, p. 25-33, 2019. DOI: 10.1016/j.niox.2019.09.007. Disponível em: http://repositorio.ipen.br/handle/123456789/30458. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.