Simultaneous hydrogel crosslinking and silver nanoparticle formation by using ionizing radiation to obtain antimicrobial hydrogels
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2019
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Radiation Physics and Chemistry
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Hydrogel dressings are crosslinked hydrophilic polymers able of swelling in presence of water and can be used in
many different types of wound care. In turn, in wound care, silver has been used for a long time as an effective
antimicrobial agent. Recent studies have demonstrated an increase of its antimicrobial action when it is used at
nanometer scale, that is, as silver nanoparticles (AgNPs), which have anti-inflammatory effect on infected
wounds, rashes, and mesh skin grafts. The objective of this work was to study hydrogel dressings containing
AgNPs from silver nitrate, synthesized by radiation involving the formation of silver nanoparticles with simultaneous
occurrence of crosslinking and sterilization of the polymer systems. One of the hydrogels was
prepared with poly(N-vinyl-2- pyrrolidone) (PVP) and the other with poly(vinyl alcohol) (PVA) as main studied
polymers. An aqueous solution of AgNO3 was added to both polymer systems separately. The AgNPs synthesis,
polymer crosslinking and dressing sterilization were achieved simultaneously by irradiating the resultant solutions
with gamma-rays from a 60Co source. Gel fraction, swelling in reverse osmosis water, SEM-EDS, UVvisible
spectroscopy, and antimicrobial activity were performed and characterized. The obtained results showed
that the dressings have a soft consistency, high degree of crosslinking and swelling, homogeneous distribution of
AgNPs with peaks of plasmonic bands about 400 nm, but only PVP hydrogel showed antimicrobial properties to
P. aeruginosa and normal S. aureus. Moreover, this hydrogel also showed antimicrobial properties to S. aureus
strain multiresistant to penicillins, cephalosporins, carbapenems, sulfonamides, tetracyclines, quinolones, and
aminoglycosides, whereas the PVA hydrogel showed antimicrobial properties to P. aeruginosa and bacteriostatic
activity to S. aureus. The results suggest that both synthesized dressings have potential for use in wounds and
burns infected with gram-positive and gram-negative bacteria.
Como referenciar
ALCANTARA, M.T.S.; LINCOPAN, N.; SANTOS, P.M.; RAMIREZ, P.A.; BRANT, A.J.C.; RIELLA, H.G.; LUGAO, A.B. Simultaneous hydrogel crosslinking and silver nanoparticle formation by using ionizing radiation to obtain antimicrobial hydrogels. Radiation Physics and Chemistry, v. 165, p. 1-9, 2019. DOI: 10.1016/j.radphyschem.2019.108369. Disponível em: http://repositorio.ipen.br/handle/123456789/30476. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.