Antimicrobial photodynamic therapy
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2019
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INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th
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Antimicrobial photodynamic therapy (APDT) combines the use of light with a photosensitizer (PS) and oxygen to kill
microbial cells. Even though this technique was first reported in the beginning of the 20th century, APDT never took off
as antimicrobial chemotherapy did. However, microbial resistance to chemotherapy is currently expanding in faster rates
than drug discovery. Therefore, introduction of therapeutic alternatives that bypass mechanisms of drug resistance now
presents an urgent status. Fortunately, the scientific and technological development related to APDT made it far more
feasible for mainstream clinical applications. Our research group has been working on mechanisms and applications of
APDT for almost 20 years. We have already reported that successful APDT results depend on a number of factors, such
as PS and light parameters, cell type, and oxygen abundance, among others. We have also demonstrated that APDT is an
effective adjuvant in endodontics and periodontics and can be a non-invasive treatment for caries, candidiasis and
cutaneous leishmaniasis. In Veterinary Medicine, we have reported effective treatment for penguin pododermatitis, snake
stomatitis and dog otitis. This presentation will give an integrated perspective from the basic APDT mechanisms, preclinical
and clinical trials to protocol optimization and future perspectives.
Como referenciar
RIBEIRO, MARTHA S.; SABINO, CAETANO P.; NUNEZ, SILVIA C. Antimicrobial photodynamic therapy: from basis to clinical applications. In: HASAN, TAYYABA (ed.). In: INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th, June 28 - July 4, 2019, Cambridge, Massachusetts, USA. Proceedings... Bellingham, WA, USA: SPIE, 2019. p. 1107048-1 - 1107048-9. (Proceedings SPIE 11070). DOI: 10.1117/12.2527918. Disponível em: http://repositorio.ipen.br/handle/123456789/30947. Acesso em: 23 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.