Metformin release with pseudoboehmite
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2019
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BRAZIL MRS MEETING, 18th
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Diabetes Mellitus is a chronic disease in which high levels of blood glucose are
found. It arises when the pancreas does not produce enough insulin, a hormone
that regulates blood sugar concentration. It also occurs when the body does not
properly use the insulin it produces. There are two main forms of diabetes: type 1
diabetes, the treatment of which is insulin injections, and type 2 diabetes, where
the body's cells do not respond to insulin properly. In Brazil the diseases that
most affect the population are diabetes, hypertension and stroke. The number of
Brazilians diagnosed with diabetes has grown 61.8% in the last 10 years. In 2006,
5.5% of the population had the disease and in 2016 8.9% [1]. It has also been
observed in Brazil that diabetes increases with age and is almost three times
higher among those with lower schooling. People between the ages of 18 and 24
have a rate of 0.9%, between 35 and 44 years old, the rate is 5.2%, and among
people aged 55-64 years, the number reaches 19.6%. The largest registry,
however, is in the population aged 65 years or older, which presents an index of
27.2%. In recent years, several papers reported the use of pseudoboehmite for
use in controlled drug delivery systems. The drugs tested include atenolol [2],
Glucantime® [3], acyclovir [4] and DOX, a typical chemotherapeutic anticancer
drug [5]. In this research pseudoboehmite was produced by sol-gel process and
metformin was incorporated in the gel of pseudoboehmite. After that the gel was
vacuum filtered and dried to obtain a powder by freeze-drying. The dry powder
was characterized by x-ray diffraction, thermal analysis (Thermogravimetric
analysis and differential thermal analysis), nitrogen adsorption isotherm, specific
surface area by B.E.T. method and scanning electron microscopy using secondary
electron detector and EDS detector. The results shows that the drug was
homogeneously incorporated in the pseudoboehmite.
Como referenciar
LAZARIN JUNIOR, ELOI; MUNHOZ JUNIOR, ANTONIO H.; MIRANDA, LEILA F. de; SARMENTO, BRUNO F.C.C.; BERNUSSI, AYRTON; LIMA, NELSON B. de; ROSSI, MAURA V.; PERES, RENATO M.; FLORENCIO, ODILA. Metformin release with pseudoboehmite. In: BRAZIL MRS MEETING, 18th, September 22-26, 2019, Balneário Camburiú, SC. Abstract... São Carlos, SP: Aptor Software, 2019. p. 955-956. Disponível em: http://repositorio.ipen.br/handle/123456789/31045. Acesso em: 19 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.