Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion
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2020
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Journal of Dentistry
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Objective: To evaluate the anti-erosive effect of solutions containing β-tricalcium phosphate (β-TCP) nanoparticles
functionalized with fluoride or with fluoride plus stannous on enamel and dentin.
Methods: β-TCP nanoparticles were synthesized and characterized by X-ray diffraction (XRD) and transmission
electron microscopy (TEM). Sixty enamel and dentin specimens were randomly allocated into the groups
(n=10): Control (water); F (NaF, 225 ppm F−); F+Sn (NaF+SnCl2, 800 ppm Sn2+); F+β-TCP (F+40 ppm β-
TCP); F+Sn+β-TCP (F+Sn+40 ppm β-TCP); F+Sn+100β-TCP (F+Sn+100 ppm β-TCP). Specimens underwent
erosion-remineralization cycling (5 min immersion into 1 % citric acid solution and 60 min exposure to
artificial saliva, 4×/day, 5 days). Immersion in the test solutions was performed for 2 min, 2×/day. Surface loss
(SL, in μm) was determined by optical profilometry at the end of cycling. Data were analyzed using one way-
ANOVA and Tukey’s tests (α=0.05).
Results: XRD confirmed the β-TCP phase. TEM micrographs showed differences between the bare nanoparticle
and the β-TCP functionalized with F and Sn. All enamel groups presented lower SL than the control, with F+Sn,
F+Sn+β-TCP, and F+Sn+100β-TCP showing the lowest values. For dentin, all the groups had lower SL than
the control. F+β-TCP presented the lowest SL, significantly differing from all the other groups.
Conclusion: β-TCP nanoparticles functionalized with fluoride showed improved anti-erosive effect compared to
the fluoride solution on dentin. There was no significant effect of the β-TCP nanoparticles functionalized with
fluoride plus stannous in both substrates.
Clinical Relevance: β-TCP nanoparticles are a promising agent to be added to oral health products to improve the
protective effect of fluoride against dentin erosion.
Como referenciar
VIANA, ITALLO E.L.; LOPES, RAQUEL M.; SILVA, FLAVIA R.O.; LIMA, NELSON B.; ARANHA, ANA C.C.; FEITOSA, SABRINA; SCARAMUCCI, TAIS. Novel fluoride and stannous -functionalized β-tricalcium phosphate nanoparticles for the management of dental erosion. Journal of Dentistry, v. 92, p. 1-6, 2020. DOI: 10.1016/j.jdent.2019.103263. Disponível em: http://repositorio.ipen.br/handle/123456789/31094. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.