Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels
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2020
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International Journal of Polymeric Materials and Polymeric Biomaterials
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Chitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in
poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter
of 250nm and zeta potential of 35mV with drug loading and encapsulation efficiency of
98.4 ± 0.3% and 36.9 ± 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition and micellization
temperatures. PL407-PL403 systems presented G0 >G00 compared to PL407. SAXS patterns
revealed transitions from lamellar to hexagonal phase organizations with low drug release rates, in
the presence of CS-TPP nanoparticles. NPX-CS-TPP-PL407 induced lower cytotoxicity compared to
PL407-PL403 in fibroblasts and osteoblasts, making them promising systems for intra-articular
delivery.
Como referenciar
MARIANO, KELLI C.F.; NASCIMENTO, MONICA H.M. do; QUEROBINO, SAMYR M.; CAMPOS, ESTEFANIA V.R.; OLIVEIRA, JHONES L. de; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.; ALBERTO-SILVA, CARLOS; PAULA, ENEIDA de; LOMBELLO, CHRISTIANE B.; LIMA, RENATA de; FRACETO, LEONARDO F.; ARAUJO, DANIELE R. de. Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicity. International Journal of Polymeric Materials and Polymeric Biomaterials, v. 69, n. 9, p. 592-603, 2020. DOI: 10.1080/00914037.2019.1596909. Disponível em: http://repositorio.ipen.br/handle/123456789/31100. Acesso em: 24 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.