Effects of photobiomodulation on breast tumor- bearing mice before radiotherapy
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2020
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Lasers in Medical Science
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Photobiomodulation (PBM) has been studied to modify the cellular
response to ionizing radiation. However, its combination with
radiotherapy (RT) has not been reported in cancer treatment. The
aim of this study was to evaluate the effects of PBM applied
before RT on breast tumor-bearing mice. Female BALB/c mice
were inoculated with breast 4T1 cells into mammary fat pad
and divided into 4 groups (n =5 per group): control (with no
treatment), only RT, and PBM combined to RT in two different
protocols. RT was locally applied using a 60Co source with dose
of 60 Gy in fractions of 15 Gy. For PBM, a red laser (660 nm,
500 mW/cm2) was used in two regimes: single exposure 24 h
before RT (fluence of 150 J/cm2) and immediately before each
RT session (fluence of 37.5 J/cm2 per session). After treatment,
tumor volume, platelets, white and red blood cell levels were
evaluated during 14 days. Our results showed no statistically significant
differen ces in t umor volume, platelet and red blood cell
levels comparing control, RT and PBM+RT groups. However,
PBM was able to sustain normal white blood cell levels compared
to RT and control groups. In addition, mice that received PBM
concomitant with RT presented a longer survival. In fact, for this
group only 12.5 % of the animals died during experimental period.
These findings indicate that PBM could be combined to RT to
provide therapeutic anti-cancer benefits.
Como referenciar
SILVA, C.R.; RIBEIRO, M.S. Effects of photobiomodulation on breast tumor- bearing mice before radiotherapy. Lasers in Medical Science, v. 35, n. 1, p. 269-269, 2020. DOI: 10.1007/s10103-019-02900-7. Disponível em: http://repositorio.ipen.br/handle/123456789/31111. Acesso em: 19 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.