Photobiomodulation activates glucose uptake in brown adipose tissue of obese mice
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2020
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Lasers in Medical Science
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Resumo
Mammal fat consists ofwhite and brown adipose tissues (WATand BAT).
Although most fat is energy-storing WAT, brown adipocytes dissipate
energy as heat. Obese subjects exhibit BAT hyporesponsiveness to classical
stimuli as cold, hence increasing BAT thermogenic capacity
could be an i n t er e s t i n g t a rget f o r t r eating obesity.
Photobiomodulation (PBM) seems to be a feasible alternative to
activate BAT, although it has not been applied for this purpose
until now. In this study, adult C57Bl/6 mice were fed with a
hyperlipidic diet (HF) during 15 weeks to induce obesity. Then,
they were divided into two groups: HF and HF660. The
interscapular BAT of HF660 mice was exposed to a single irradiation
using a 662 ± 20 nm LED (5.7 Jcm-2 at 19 mWcm-2,
delivered during 300 s). The HF group was sham-irradiated.
Eutrophic animals were also used. Animals received 200 mCi of
18F-FDG and were exposed to cold for basal register of PET-CT
images. After PBM or sh am treat ment, mice were once again
exposed to cold before PET-CT image acquisition. Our results
showed that PBM was able to activate BAT in obese mice
through higher glucose uptake. In contrast, PBM and shamirradiated
normal fed mice presented similar levels of glucose
uptake. Taking together, our findings suggest that PBM applied
to the BAT is able to promote glucose uptake by obese mice and
could be an interesting approach to manage obesity and its correlated
morbidities.
Como referenciar
YOSHIMURA, TANIA; RIBEIRO, MARTHA S. Photobiomodulation activates glucose uptake in brown adipose tissue of obese mice. Lasers in Medical Science, v. 35, n. 1, p. 280-280, 2020. DOI: 10.1007/s10103-019-02900-7. Disponível em: http://repositorio.ipen.br/handle/123456789/31113. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.