Histopathological changes in zebrafish exposed to sublethal concentrations of 89nm silver nanoparticles for application in environmental diagnostics
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2020
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Human and Ecological Risk Assessment
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The use of biomarkers as indicators of environmental contamination
has been shown to be an excellent indicator of changes in biota.
Histopathological lesions are commonly used in biomonitoring studies
as they provide information regarding both acute and chronic
exposure. The use of nanoparticle materials has been widespread in
recent years. However, not much is known about their ecological
effects on the natural environment. Thus, the aim of this study was
to assess the sublethal effects of silver nanoparticles (AgNP) with
mean diameters of 89nm in the zebrafish Danio rerio by the determination
of the LC50; 48 h and histopathological assays in gills. The
obtained LC50; 48 h was 8.18 mgL 1. The histopathological gill assessment
showed primary responses indicative of acute damage as
aneurysms (32.76%), hyperplasia (20.69%) and partial (30.17%) and
total lamellar fusion (6.9%) of secondary lamellae. No deposition of
AgNP was observed in any tested sample gills, suggesting other
organs target to absorption and detoxification. In fact, the AgNP
causes sublethal damage in the gills of zebrafish but is not able to
accumulate in this tissue. Finally, the data shown in this study contribute
to the construction of a database on the AgNP exposure in
aquatic organisms.
Como referenciar
AZEVEDO, JULIANA de S.; QUINTINO, MARILIA T.A.; ROGERO, SIZUE O.; ZAMPIERI, MARIA C.T.; ROGERO, JOSE R. Histopathological changes in zebrafish exposed to sublethal concentrations of 89nm silver nanoparticles for application in environmental diagnostics. Human and Ecological Risk Assessment, v. 26, n. 5, p. 1207-1220, 2020. DOI: 10.1080/10807039.2018.1560219. Disponível em: http://repositorio.ipen.br/handle/123456789/31328. Acesso em: 24 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.