Advanced design, simulation, and dosimetry of a novel rectal applicator for contact brachytherapy with a conventional HDR 192Ir source
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2020
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Brachytherapy
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PURPOSE: Dose escalation yields higher complete response to rectal tumors, which may enable
the omission of surgery. Dose escalation using 50 kVp contact x-ray brachytherapy (CXB) allow the
treatment of a selective volume, resulting in low toxicity and organs-at-risk preservation. However,
the use of CXB devices is limited because of its high cost and lack of treatment planning tools.
Hence, the MAASTRO applicator (for HDR 192Ir sources) was developed and characterized by
measurements and Monte Carlo simulations to be a cost-effective alternative to CXB devices.
METHODS AND MATERIALS: A cylindrical applicator with lateral shielding was designed to
be used with a rectoscope using its tip as treatment surface. Both the applicator and the rectoscope
have a slanted edge to potentially allow easier placement against tumors. The applicator design was
achieved by Monte Carlo modeling and validated experimentally with film dosimetry, using the
Papillon 50 (P50) device as reference.
RESULTS: The applicator delivers CXB doses in less than 9 min using a 20375 U source for a
treatment area of approximately 20 20 mm2 at 2 mm depth. Normalized at 2 mm, the dose falloff
for depths of 0 mm, 5 mm, and 10 mm are 130%, 70%, and 43% for the P50 and 140%, 67%, and
38% for the MAASTRO applicator, respectively.
CONCLUSIONS: The MAASTRO applicator was designed to use HDR 192Ir sources to deliver a
dose distribution similar to those of CXB devices. The applicator may provide a cost-effective solution
for endoluminal boosting with clinical treatment planning system integration.
Como referenciar
BELLEZZO, MURILLO; FONSECA, GABRIEL P.; VONCKEN, ROBERT; VERRIJSSEN, AN-SOFIE; VAN BEVEREN, CELINE; ROELOFS, ERIK; YORIYAZ, HELIO; RENIERS, BRIGITTE; VAN LIMBERGEN, EVERT J.; BERB EE, MAAIKE; VERHAEGEN, FRANK. Advanced design, simulation, and dosimetry of a novel rectal applicator for contact brachytherapy with a conventional HDR 192Ir source. Brachytherapy, v. 19, n. 4, p. 544-553, 2020. DOI: 10.1016/j.brachy.2020.03.009. Disponível em: http://repositorio.ipen.br/handle/123456789/31351. Acesso em: 19 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.