Anticancer activities of the quinone-methide triterpenes maytenin and 22-β-hydroxymaytenin obtained from cultivated Maytenus ilicifolia roots associated with down-regulation of miRNA-27a and miR-20a/miR-17-5p
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2020
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Molecules
Resumo
Natural triterpenes exhibit a wide range of biological activities. Since this group of
secondary metabolites is structurally diverse, effects may vary due to distinct biochemical interactions
within biological systems. In this work, we investigated the anticancer-related activities of the
quinone-methide triterpene maytenin and its derivative compound 22-β-hydroxymaytenin, obtained
from Maytenus ilicifolia roots cultivated in vitro. Their antiproliferative and pro-apoptotic activities
were evaluated in monolayer and three-dimensional cultures of immortalized cell lines. Additionally,
we investigated the toxicity of maytenin in SCID mice harboring tumors derived from a squamous cell
carcinoma cell line. Both isolated molecules presented pronounced pro-apoptotic activities in four cell
lines derived from head and neck squamous cell carcinomas, including a metastasis-derived cell line.
The molecules also induced reactive oxygen species (ROS) and down-regulated microRNA-27a and
microRNA-20a/miR-17-5p, corroborating with the literature data for triterpenoids. Intraperitoneal
administration of maytenin to tumor-bearing mice did not lead to pronounced histopathological
changes in kidney tissue, suggesting low nephrotoxicity. The wide-ranging activity of maytenin and
22-β-hydroxymaytenin in head and neck cancer cells indicates that these molecules should be further
explored in plant biochemistry and biotechnology for therapeutic applications.
Como referenciar
HERNANDES, CAMILA; MIGUITA, LUCYENE; SALES, ROMARIO O. de; SILVA, ELISANGELA de P.; MENDONÇA, PEDRO O.R. de; SILVA, BRUNA L. da; KLINGBEIL, MARIA de F.G.; MATHOR, MONICA B.; RANGEL, ERIKA B.; MARTI, LUCIANA C.; COPPEDE, JULIANA da S.; NUNES, FABIO D.; PEREIRA, ANA M.S.; SEVERINO, PATRICIA. Anticancer activities of the quinone-methide triterpenes maytenin and 22-β-hydroxymaytenin obtained from cultivated Maytenus ilicifolia roots associated with down-regulation of miRNA-27a and miR-20a/miR-17-5p. Molecules, v. 25, n. 3, p. 1-19, 2020. DOI: 10.3390/molecules25030760. Disponível em: http://repositorio.ipen.br/handle/123456789/31401. Acesso em: 29 Mar 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.