Descriptive epidemiological and pathological study of canine renal cell carcinoma
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2020
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Journal of Veterinary Science & Medical Diagnosis
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Resumo
Renal cell carcinoma (RCC) accounts for 0.5–1.5% of all canine
tumor types and is very aggressive, rapidly growing, and
metastasis-generating, culminating in the death of the animal. The
management of canine RCC lacks predictive biomarkers. The aim
of this study is to conduct an epidemiological and pathological
analysis of dogs affected with RCC.A retrospective and descriptive
review of studies published between January 2001 to December
2019 was carried out using the following electronic databases: Web
of Science, PubMed, SciELO, Science Direct. Twenty-one articles
from 11 countries were included in the study, totaling 258 cases.
Histopathological analysis based on cytological criteria showed
that cromophobic and clear cell carcinoma were the most frequent
subtypes. The histological classification revealed that papillary and
tubular carcinoma accounted for 70% of the cases. Vimentin, Pax8,
CKs (CK AE1/AE3, CK CAM5.2 and CK7), COX-2, Napsin-A, CD10
and CD117 were the most commonly used diagnostic biomarkers,
corresponding to 80% of cases. Moreover, 14-3-3σ and COX-2
were also used as predictive biomarkers for canine RCC.
In conclusionVimentin, Pax8, CKs (CK AE1/AE3, CK CAM5.2
and CK7), COX-2, Napsin-A, CD10 and CD117 were the most
commonly used diagnostic biomarkers, corresponding to 80% of
cases. Moreover, 14-3-3σ and COX-2 were also used as a predictive
biomarker for canine RCC.
Como referenciar
BELLINI, MARIA H.; JORGE, AMANDA S.; MARUMO, MATHEO B.; OLIVEIRA, SORAIA B. de. Descriptive epidemiological and pathological study of canine renal cell carcinoma. Journal of Veterinary Science & Medical Diagnosis, v. 9, n. 3, p. 1-4, 2020. Disponível em: http://repositorio.ipen.br/handle/123456789/31415. Acesso em: 23 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.