Synthesis and characterization of PVP nanogels prepared by gamma radiation using 60Co source
Carregando...
Data
Data de publicação:
2019
Orientador
Título da Revista
ISSN da Revista
Título do Volume
É parte de
É parte de
É parte de
É parte de
WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th
Exportar
Resumo
Nanogels are promising and innovative systems in nanometer scale, with particle size range
varying from 0 to 100 nm, of great potential in nanomedicine, pharmaceutics and bionanotechnology.
They present several advantages such as capacity of injection into the
circulation reaching target tissues and ability to deliver their payloads locally and intracellularly.
Nanogels are defined as two-component system on nanometer scale consisting of a permanent
three-dimensional network of linked polymer chains, and molecules of a solvent filling the pores
of this network. They are formed by intramolecular crosslinking that can be achieved by the use
of ionizing radiation, this method allows the formation of nanogels free of additives, rendering
them non-toxic, a fundamental requirement for biomedical application. In this work, five samples
of nanogels were developed using a 25 mM PVP solution. The samples were saturated with
argon and prepared in multipurpose cobalt-60 gamma irradiator using doses of 1, 2, 5, 10 and
25 kGy at a dose rate of 10 kGy/hour corresponding, respectively, to samples A, B, C, D and E.
These samples were morphologically characterized using atomic force microscopy (AFM) as well
as the pristine PVP solution. The mean particle size of the samples as well as the determination
of polydispersity index was performed in equipment Zetasizer Nano ZS - Malvern® and the
determination of radius of gyration and molecular weight was realized in equipment Heleos -
Wyatt®. The mean particle size of the samples A, B, C, D and E, were, respectively, 41.89,
46.85, 61.04, 62.79 and 62.11 nm and the mean particle size of the pristine PVP solution was
43.28 nm. The AFM results revealed the presence of spherical nanostructures in the samples
prepared with dose equal to or more than 5 kGy (samples C, D and E). Under the conditions
evaluated in the study the morphological characterization of the nanogels revealed that the doses
of 5 kGy, 10 and 25 kGy are the most suitable doses for the nanogel formation as it led to
spherical structures when compared to the other conditions assayed.
Como referenciar
BALOGH, T.S.; KADLUBOWSKI, S.; BONTURIM, E.; VARCA, G.; LUGAO, A.B. Synthesis and characterization of PVP nanogels prepared by gamma radiation using 60Co source. In: WORKSHOP DE BIOMATERIAIS, ENGENHARIA DE TECIDOS E ORGÃOS ARTIFICIAIS, 6th, October 29-31, 2019, São Paulo, SP. Abstract... p. 245-245. Disponível em: http://repositorio.ipen.br/handle/123456789/31555. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.