Hypanus americanus mucus
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2020
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Fish skin plays important biological roles, such as the control of the osmotic
pressure gradient, protection against mechanical forces and microorganism
infections. The mucus, on the other hand, is a rich and complex
fluid, important for the fish acting as innate immunity system, swimming
and nutrition. The elasmobranch epidermis is characterized mainly by
mucus secretory cells, and marine stingrays have already been described to
present secretory glands spread throughout the body. Little is known
about the biochemical composition of the stingray mucus, but recent
studies denoted the importance of mucus in the envenomation process.
Stingrays venom are largely studied due the human medical importance of
envenoming caused by sting puncture, that evolve with local inflammation
and necrosis, and these toxic events can be correlated to the chemical
composition of the sting skin, according to the literature. Aiming to analyse the mucus composition, a new non-invasive mucus collection method was
developed that focused on peptides and proteins, and biological assays
were performed to analyze preliminary toxic and immune activities of the
Hypanus americanus mucus. Pathophysiological characterization showed
the presence of peptidases on mucus, as well that the induction of edema
and leukocyte recruitment in mice. The fractionated mucus improved
phagocytosis on macrophages and showed antimicrobial activity against T.
rubrum, C. neoformans and C. albicans in vitro. The proteomic analyses
showed the presence of immune-related proteins like actin, histones,
hemoglobin, and ribosomal proteins. This protein pattern is similar to
those reported for other fish mucus and stingray venom. This is the first
report depicting the Hypanus stingray mucus composition, highlighting its
biochemical composition and importance for the stingray immune system
and the possible role on the envenomation process.
Como referenciar
COELHO, GUILHERME R.; PREZOTTO NETO, JOSE P.; BARBOSA, FERNANDA C.; SANTOS, RAFAEL S.; BRIGATTE, PATRICIA; SPENCER, PATRICK J.; SAMPAIO, SANDRA C.; D'AMELIO, FERNANDA; PIMENTA, DANIEL C.; SCIANI, JULIANA M. Hypanus americanus mucus: a new point of view about stingray immunity and toxins. Toxicon, v. 177, p. S34-S34, 2020. Supplement 1. DOI: 10.1016/j.toxicon.2019.12.047. Disponível em: http://200.136.52.105/handle/123456789/31673. Acesso em: 20 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.