Solid-liquid equilibrium of paracetamol in water-ethanol and water-propylene glycol mixtures
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2021
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Journal of Molecular Liquids
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Resumo
Solubility is one of most important property to produce active pharmaceutical ingredients (APIs), beyond of
being related to its bioavailability. In this context, itwas determined paracetamol solid-liquid equilibriumin temperatures
from20 to 50 °C for two solvent systems:water - ethanol andwater - propylene glycol (PG), by refractometry
method. The experimental results were compared with five thermodynamic models (Apelblat,Wilson,
UNIQUAC, NRTL and λh) and data from the literature, showing good correlations for Apelblat and the best predictive
fit for the NRTL model in both solvent mixtures. Maximum solubility values were observed in a 75% ethanol
composition, this result being unusual and not the same with PG. the results of this work were compared
with the literature and some references point to similar behavior. Optical microscopy and X-ray diffractionmeasurements
of the solids in equilibrium with the liquid indicate that maximum solubility is not associated with a
change in the crystalline structure of the solid
Como referenciar
ASSIS, GABRIEL P.; GARCIA, RAFAEL H.L.; DERENZO, SILAS; BERNARDO, ANDRE. Solid-liquid equilibrium of paracetamol in water-ethanol and water-propylene glycol mixtures. Journal of Molecular Liquids, v. 323, p. 1-13, 2021. DOI: 10.1016/j.molliq.2020.114617. Disponível em: http://repositorio.ipen.br/handle/123456789/31935. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.