Light-based non-thermal therapy
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2021
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CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th
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Light-based non-thermal therapies are evolving as promising non-invasive and cost-effective medical
technologies. These therapeutic platforms mainly encompass photobiomodulation (PBM) and
photodynamic therapy (PDT), which use visible or near infrared (NIR) light to induce biological responses
without any significant heating effects. For PBM, it is most commonly used red or NIR light to optimize
light penetration into biological tissues. The photon absorption by natural chromophores at these spectral
regions cause photophysical and photochemical reactions inside cells that trigger several biological
effects such as to accelerate wound healing, reduce inflammation and relief pain, depending on light
parameters and target tissue. On the other hand, PDT makes use of photoactivated drugs, also called as
photosensitizers, which absorb light to induce chemical reactions that kill microbial or cancer cells by
oxidative stress. Our group have been investigating the mechanisms and several applications of PBM
and antimicrobial PDT (APDT) for almost 20 years. In this lecture I will share our experience in the area
to discuss how PBM and APDT could be used to revolutionize health care in the photonics era. An
integrated perspective from the basic mechanisms, preclinical and clinical trials for both therapies will be
presented, including PBM on cancer management and APDT against drug-resistant pathogens. The
lecture will also highlight future perspectives.
Como referenciar
RIBEIRO, MARTHA S. Light-based non-thermal therapy: from basis to clinical applications. In: CONGRESS OF THE INTERNATIONAL UNION FOR PURE APPLIED BIOPHYSICS, 20th; ANNUAL MEETING OF THE BRAZILIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, 50th; CONGRESS OF BRAZILIAN BIOPHYSICS SOCIETY, 45th; BRAZILIAN SOCIETY ON NUCLEAR BIOSCIENCES CONGRESS, 13th, October 4-8, 2021, São Paulo, SP. Abstract... São Paulo, SP: Sociedade Brasileira de Bioquímica e Biologia Molecular (SBBq), 2021. p. 39-39. Disponível em: http://repositorio.ipen.br/handle/123456789/32860. Acesso em: 25 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.