Application of electron beam irradiation for remediation of pharmaceutical compounds in water
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2022
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CONGRESO ARGENTINO DE LA SOCIEDAD DE TOXICOLOGÍA Y QUÍMICA AMBIENTAL, 8th
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Resumo
A significant number of pharmaceutical active compounds have been released in the
aquatic environment. These compounds are not fully removed from water and wastewater
treatment plants. Furthermore, these contaminants are not commonly monitored, and they
possess the potential to cause adverse ecological and human health effects. Electron
Beam Irradiation (EBI) have been applied as an alternatively green method in water
management, being efficient for removing organic recalcitrant pollutants at low doses. This
work aims to assess the effect of EBI on toxicity of four pharmaceuticals from distinct class
(anti-inflammatory, antidepressant, antibiotic, and antidiabetic) using organism from
different trophic levels. Acetylsalicylic acid and fluoxetine hydrochloride were obtained
from Labsynth (>99.5%) and Divis Pharmaceuticals Pvt. Ltd (98.8%), respectively.
Metformin hydrochloride (97%) and ciprofloxacin (>98%) were purchased from Sigma-
Aldrich. All aqueous solution were diluted using ultra-pure water. Acute toxicity assays with
Daphnia similis and Vibrio fischeri were based on ABNT/NBR standard methods. The
evaluated endpoint was immobility and bioluminescence inhibition, respectively. The yeast
assays were carried by monitoring of changes in the specific conductivity of suspensions
of S. cerevisiae. All the assays were performed in triplicate. The toxicity results of the
microcrustacean and the bacteria were expressed in Toxicity Factor. For the yeast, data
were analyzed by F-test and t-test using a significance level of 0.05. The UV-Vis spectrum
showed changes in all pharmaceutical’s spectrum after irradiation at 2.5 kGy. The toxicity
results indicated that the effects varied depending on the organism and the studied
pharmaceutical. For acetylsalicylic acid, increase of toxicity was observed for all three the
organism. In contrast, for fluoxetine, a great toxicity removal was achieved for D. similis
while and for the bacteria and the yeast no changes of toxicity were noted. Regarding
metformin, the radiolytic byproducts were only toxic to the microcrustacean, possibly
including residual hydrogen peroxide. Finally, for ciprofloxacin, toxicity increase was
verified for D. similis and V. fischeri, while detoxification was observed for S. cerevisiae. In
conclusion, the present work demonstrated EBI is effective for removing pharmaceuticals
and showed the importance of using different organism for toxicity assessment.
Como referenciar
TOMINAGA, F.K.; BOIANI, N.F.; SILVA, T.T.; LEO, P.; BORRELY, S.I. Application of electron beam irradiation for remediation of pharmaceutical compounds in water. In: CONGRESO ARGENTINO DE LA SOCIEDAD DE TOXICOLOGÍA Y QUÍMICA AMBIENTAL, 8th, March 7-11, 2022, Mar del Plata, Argentina. Abstract... Mar del Plata, Argentina: Universidad Nacional de Mar del Plata, 2022. p. 253-253. Disponível em: http://repositorio.ipen.br/handle/123456789/33895. Acesso em: 23 Apr 2024.
Esta referência é gerada automaticamente de acordo com as normas do estilo IPEN/SP (ABNT NBR 6023) e recomenda-se uma verificação final e ajustes caso necessário.