Navegação Periódicos - Artigos por Autores IPEN "FAINTUCH, BLUMA L."

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  • IPEN-DOC 18044

    FAINTUCH, BLUMA L. ; OLIVEIRA, ERICA A.; NUNEZ, EUTIMIO G.F.; MORO, ANA M.; NANDA, P.K.; SMITH, CHARLES J.. Comparison of two peptide radiotracers for prostate carcinoma targeting. Clinics, v. 67, n. 2, p. 163-170, 2012.

    Palavras-Chave: neoplasms; prostate; targets; labelling; peptides; technetium 99; comparative evaluations


  • IPEN-DOC 21229

    FAINTUCH, BLUMA L. ; OLIVEIRA, ERICA A. ; NUNEZ, EUTIMIO G.F. ; MORO, ANA M.; NANDA, P.K.; SMITH, CHARLES J.. Comparison of two peptide radiotracers for prostate carcinoma targeting. Clinics, v. 67, n. 2, p. 163-170, 2012. DOI: 10.6061/clinics/2012(02)12

    Abstract: OBJECTIVES: Scintigraphy is generally not the first choice treatment for prostate cancer, although successful studies using bombesin analog radiopeptides have been performed. Recently, a novel peptide obtained using a phage display library demonstrated an affinity for prostate tumor cells. The aim of this study was to compare the use of a bombesin analog to that of a phage display library peptide (DUP-1) radiolabeled with technetium-99m for the treatment of prostate carcinoma. The peptides were first conjugated to S-acetyl-MAG3 with a 6-carbon spacer, namely aminohexanoic acid. METHODS: The technetium-99m labeling required a sodium tartrate buffer. Radiochemical evaluation was performed using ITLC and was confirmed by high-performance liquid chromatography. The coefficient partition was determined, and in vitro studies were performed using human prostate tumor cells. Biodistribution was evaluated in healthy animals at various time points and also in mice bearing tumors. RESULTS: The radiochemical purity of both radiotracers was greater than 95%. The DUP-1 tracer was more hydrophilic (log P = -2.41) than the bombesin tracer (log P = -0.39). The biodistribution evaluation confirmed this hydrophilicity by revealing the greater kidney uptake of DUP-1. The bombesin concentration in the pancreas was greater than that of DUP-1 due to specific gastrin-releasing peptide receptors. Bombesin internalization occurred for 78.32% of the total binding in tumor cells. The DUP-1 tracer showed very low binding to tumor cells during the in vitro evaluation, although tumor uptake for both tracers was similar. The tumors were primarily blocked by DUP- 1 and the bombesin radiotracer primarily targeted the pancreas. CONCLUSION: Further studies with the radiolabeled DUP-1 peptide are recommended. With further structural changes, this molecule could become an efficient alternative tracer for prostate tumor diagnosis.

    Palavras-Chave: neoplasms; prostate; targets; labelling; peptides; technetium 99; comparative evaluations


  • IPEN-DOC 13735

    SANTOS, RODRIGO L.S.R.; FAINTUCH, BLUMA L. ; TEODORO, RODRIGO. Estudos in vitro e in vivo de analogo da timidina marcada com complexo organometalico de tecnecio-99m para potencial uso em diagnostico tumoral. Revista Brasileira de Ciencias Farmaceuticas, v. 44, n. 1, p. 85-95, 2008.

    Palavras-Chave: thymidine; radiopharmaceuticals; technetium 99; organometallic compounds; tracer techniques; neoplasms; diagnosis


  • IPEN-DOC 23929

    OLIVEIRA, ERICA A. de ; FAINTUCH, BLUMA L. ; TARGINO, ROSELAINE C.; MORO, ANA M.; MARTINEZ, RAQUEL C.R.; PAGANO, ROSANA L.; FONOFF, ERICH T.; CARNEIRO, CAMILA de G.; GARCEZ, ALEXANDRE T.; FARIA, DANIELE de P.; BUCHPIGUEL, CARLOS A.. Evaluation of GX1 and RGD‑GX1 peptides as new radiotracers for angiogenesis evaluation in experimental glioma models. Amino Acids, v. 48, n. 3, p. 821-831, 2016. DOI: 10.1007/s00726-015-2130-y

    Abstract: Gliomas are the most common type among all central nervous system tumors. The aggressiveness of gliomas is correlated with the level of angiogenesis and is often associated with prognosis. The aim of this study is to evaluate the novel GX1 peptide and the heterodimer RGD-GX1 radiolabeled with technetium-99m, for angiogenesis detection in glioma models. Radiolabeling and radiochemical controls were assessed for both radioconjugates. In vitro binding studies in glioma tumor cells were performed, as well as biodistribution in SCID mice bearing tumor cells, in order to evaluate the biological behavior and tumor uptake of the radiocomplexes. Blocking and imaging studies were also conducted. MicroSPECT/ CT images were acquired in animals with experimentally implanted intracranial tumor. Open field activity was performed to evaluate behavior, as well as perfusion and histology analysis. The radiochemical purity of both radiotracers was greater than 96 %. In vitro binding studies revealed rather similar binding profile for each molecule. The highest binding was for RGD-GX1 peptide at 120 min in U87MG cells (1.14 ± 0.35 %). Tumor uptake was also favorable for RGD-GX1 peptide in U87MG cells, reaching 2.96 ± 0.70 % at 1 h p.i. with 47 % of blocking. Imaging studies also indicated better visualization for RGD-GX1 peptide in U87MG cells. Behavior evaluation pointed brain damage and histology studies confirmed actual tumor in the uptake site. The results with the angiogenesis seeking molecule 99mTc-HYNIC-E- [c(RGDfk)-c(GX1)] were successful, and better than with 99mTc-HYNIC-PEG4-c(GX1). Future studies targeting angiogenesis in other glioma and nonglioma tumor models are recommended.


  • IPEN-DOC 23930

    OLIVEIRA, ERICA A. de ; LAZOVIC, JELENA; GUO, LEA; SOTO, HORACIO; FAINTUCH, BLUMA L. ; AKHTARI, MASSOUD; POPE, WHITNEY. Evaluation of magnetonanoparticles conjugated with new angiogenesis peptides in intracranial glioma tumors by MRI. Applied Biochemistry and Biotechnology, 2017. DOI: 10.1007/s12010-017-2443-2

    Abstract: Angiogenesis plays a critical role in progression of malignant gliomas. The development of glioma-specific labeling molecules that can aid detection and visualization of angiogenesis can help surgical planning and improve treatment outcome. The aim of this study was to evaluate if two peptides (GX1 and RGD-GX1) linked to angiogenesis can be used as an MR-imaging markers of angiogenesis. MR imaging was performed in U87 glioblastoma-bearing NOD-SCID mice at different time points between 15 and 120 min post-injection to visualize particle distribution. GX1 and RGD-GX1 exhibited the highest accumulation in U87 glioblastoma at 120 min post i.v. administration. GX1-conjugated agents lead to higher decrease in transverse relaxation time (T2) (i.e., stronger contrast enhancement) than RGD-GX1-conjugated agents in U87 glioblastoma tumor model. In addition, we tested if U87-IDH1R132 mutated cell line had different pattern of GX1 or RGD-GX1 particle accumulation. Responses in U87-IDH1WT followed a similar pattern with GX1 contrast agents; however, lower contrast enhancement was observed with RGD-GX1 agents. The specific binding of these peptides to human glioblastoma xenograft in the brain was confirmed by magnetic resonance imaging. The contrast enhancement following injection of magnetonanoparticles conjugated to GX1 peptide matched well with CD31 staining and iron staining.


  • IPEN-DOC 23933

    FAINTUCH, BLUMA L. ; SEO, DANIELE ; OLIVEIRA, ERICA A. de ; TARGINO, ROSELAINE C.; MORO, ANA M.. Evaluation of the influence of the conjugation site of the chelator agent HYNIC to GLP1 antagonist radiotracer for insulinoma diagnosis. Current Radiopharmaceuticals, v. 10, n. 1, p. 65-72, 2017. DOI: 10.2174/1874471010666170126143636

    Abstract: Background and Objective: Radiotracer diagnosis of insulinoma, can be done using somatostatin or glucagon-like peptide 1 (GLP-1). Performance of GLP-1 antagonists tends to be better than of agonists. Methods: We investigated the uptake of the antagonist exendin (9-39), radiolabeled with technetium-99m. Two different sites of the biomolecule were selected for chelator attachment. Results: HYNIC-beta Ala chelator attached to serine (C-terminus) of exendin, was associated with higher tumor uptake than to aspartate (N-terminus). Conclusion: The chelator position in the biomolecule influenced receptor uptake.


  • IPEN-DOC 22802

    SCHIPER, LUIS; FAINTUCH, BLUMA L. ; BADARO, ROBERTO J. da S.; OLIVEIRA, ERICA A. de ; CHAVEZ, VICTOR E.A.; CHINEN, ELISANGELA; FAINTUCH, JOEL. Functional investigation of bone implant viability using radiotracers in a new model of osteonecrosis. Clinics, v. 71, n. 10, p. 617-625, 2016. DOI: 10.6061/clinics/2016(10)11

    Abstract: OBJECTIVES: Conventional imaging methods are excellent for the morphological characterization of the consequences of osteonecrosis; however, only specialized techniques have been considered useful for obtaining functional information. To explore the affinity of radiotracers for severely devascularized bone, a new mouse model of isolated femur implanted in a subcutaneous abdominal pocket was devised. To maintain animal mobility and longevity, the femur was harvested from syngeneic donors. Two technetium-99m-labeled tracers targeting angiogenesis and bone matrix were selected. METHODS: Medronic acid and a homodimer peptide conjugated with RGDfK were radiolabeled with technetium-99m, and biodistribution was evaluated in Swiss mice. The grafted and control femurs were evaluated after 15, 30 and 60 days, including computed tomography (CT) and histological analysis. RESULTS: Radiolabeling achieved high (>95%) radiochemical purity. The biodistribution confirmed good blood clearance 1 hour after administration. For Tc-99m-hydrazinonicotinic acid (HYNIC)-E-[c(RGDfK)(2), remarkable renal excretion was observed compared to Tc-99m-methylene diphosphonate (MDP), but the latter, as expected, revealed higher bone uptake. The results obtained in the control femur were equal at all time points. In the implanted femur, Tc-99m-HYNIC-E-[c(RGDfK)(2) uptake was highest after 15 days, consistent with early angiogenesis. Regarding Tc-99m-MDP in the implant, similar uptake was documented at all time points, consistent with sustained bone viability; however, the uptake was lower than that detected in the control femur, as confirmed by histology. CONCLUSIONS: 1) Graft viability was successfully diagnosed using radiotracers in severely ischemic bone at all time points. 2) Analogously, indirect information about angiogenesis could be gathered using Tc-999m-HYNIC-E-[c(RGDfK)(2). 3) These techniques appear promising and warrant further studies to determine their potential clinical applications.

    Palavras-Chave: skeleton; implants; viability; tracer techniques; radioactive tracers; necrosis; mice; animals; angiogenesis; femur; technetium isotopes; technetium 99; biological models; images


  • IPEN-DOC 14527

    NUNEZ, EUTIMIO G.F.; FAINTUCH, BLUMA L. ; TEODORO, RODRIGO; WIECEK, DANIELLE P.; MARTINELLI, JOSE R.; SILVA, NATANAEL G. da ; CASTANHEIRA, CLAUDIA E.; OLIVEIRA FILHO, RENATO S. de; PASQUALINI, ROBERTO. Influence of colloid particle profile on sentinel lymph node uptake. Nuclear Medicine and Biology, v. 36, n. 7, p. 741-747, 2009.

    Palavras-Chave: colloids; dextran; lymph nodes; particle size; radiopharmaceuticals; rats; rhenium sulfides; technetium 99; tin; tissues; distribution; uptake


  • IPEN-DOC 19184

    FAINTUCH, BLUMA L. ; SOSA PEREIRA, NILDA P. ; FAINTUCH, SALOMAO; MURAMOTO, EMIKO; SILVA, CONSTANCIA P.G. . Lanreotide and octreotide complexed with technetium-99m: labeling stability and biodistribution studies. Revista Brasileira de Ciencias Farmaceuticas, v. 40, n. 1, p. 101-110, 2004.

    Palavras-Chave: endocrine diseases; somatostatin; peptides; labelling; technetium 99; radiopharmaceuticals; diagnosis; nuclear medicine


  • IPEN-DOC 16453

    FAINTUCH, BLUMA L. ; TEODORO, RODRIGO; OLIVEIRA, ERICA A. de; FERNANDEZ NUNEZ, EUTINMIO G.; FAINTUCH, JOEL. Neovascularization after ischemic injury. Evaluation with sup(99m)Tc-HYNIC-RGD. Acta Cirúrgica Brasileira, v. 26, n. 1, p. 58-63, 2011.

    Palavras-Chave: ischemia; diagnosis; technetium; labelling; scintiscanning; rats


  • IPEN-DOC 17841

    TEODORO, RODRIGO; FAINTUCH, BLUMA L. ; NUNEZ, EUTIMIO G.F.; QUEIROZ, RODRIGO G.. Neurotensin(8-13) analogue: radiolabeling and biological evaluation using different chelators. Nuclear Medicine and Biology, v. 38, n. 1, p. 113-120, 2011.

    Palavras-Chave: radiopharmaceuticals; technetium 99; radiochemical analysis; chelating agents


  • IPEN-DOC 23935

    SEO, DANIELE ; FAINTUCH, BLUMA L. ; OLIVEIRA, ERICA A. de; FAINTUCH, JOEL. Pancreas and liver uptake of new radiolabeled incretins (GLP-1 and Exendin-4) in models of diet-induced and diet-restricted obesity. Nuclear Medicine and Biology, v. 49, p. 57-64, 2017. DOI: 10.1016/j.nucmedbio.2017.03.002

    Abstract: Introduction: Radiolabeled GLP-1 and its analog Exendin-4, have been employed in diabetes and insulinoma. No protocol in conventional Diet-Induced Obesity (DIO), and Diet-Restricted Obesity (DRO), has been identified. Aiming to assess pancreatic beta cell uptake in DIO and DRO, a protocol was designed. Methods: GLP-1-βAla-HYNIC and HYNIC-βAla-Exendin-4 were labeled with technetium-99m. Four Swiss mouse models were adopted: Controls (C), Alloxan Diabetes Controls (ADC), DIO and DRO. Biodistribution and ex-vivo planar imaging were documented. Results: Radiolabeling yield was in the range of 97% and both agents were hydrophilic. Fasting Blood Glucose (FBG) was 79.2 ± 8.2 mg/dl in C, 590.4 ± 23.3 mg/dl in ADC, 234.3 ± 66.7 mg/dl in DIO, and 96.6 ± 9.3 in DRO (p = 0.010). Biodistribution confirmed predominantly urinary excretion. DIO mice exhibited depressed uptake in liver and pancreas, for both radiomarkers, in the range of ADC. DRO only partially restored such values. 99mTc-HYNIC-βAla-Exendin-4 demonstrated better results than GLP-1-βAla-HYNIC-99mTc. Conclusions: 1) Diet-induced obesity remarkably depressed beta cell uptake; 2) Restriction of obesity failed to normalize uptake, despite robust improvement of FBG; 3) HYNIC-βAla-Exendin-4 was the most useful marker; 4) Further studies are recommended in obesity and dieting, including bariatric surgery.

    Palavras-Chave: alloxan; biomedical radiography; blood; design; diet; excretion; glucose; ice; labelling; liver; metabolic diseases; mice; pancreas; surgery; technetium; technetium 99; uptake; yields


  • IPEN-DOC 17842

    NUNEZ, EUTIMIO G.F.; FAINTUCH, BLUMA L. ; TEODORO, RODRIGO; WIECEK, DANIELLE P.; SILVA, NATANAEL G. ; PAPADOPOULOS, MINAS; PELECANOU, MARIA; PIRMETTIS, IOANNIS; OLIVEIRA FILHO, RENATO S. de; DUATTI, ADRIANO; PASQUALINI, ROBERTO; QUEIROZ, RODRIGO G.. Parameters optimization defined by statistical analysis for cysteine-dextran radiolabeling with technetium tricarbonyl core. Applied Radiation and Isotopes, v. 69, n. 4, p. 663-669, 2011.

    Palavras-Chave: cysteine; dextran; radiopharmaceuticals; labelling; technetium 99; statistics


  • IPEN-DOC 22579

    FERNANDEZ, EUTIMIO G.; FAINTUCH, BLUMA L. ; OLIVEIRA, RELMA T. de; WIECEK, DANIELLE P. ; TEODORO, RODRIGO ; OLIVEIRA FILHO, RENATO S. de. Present and future of the radio-molecules used in detection of sentinel lymphatic nodes. Latin American Journal of Pharmacy, v. 28, n. 2, p. 298-303, 2009.

    Palavras-Chave: neoplasms; melanomas; metastases; radiopharmaceuticals; lymph nodes; detection; tomography; lymphatic system; animals


  • IPEN-DOC 20721

    FAINTUCH, BLUMA L. ; OLIVEIRA, ERICA A.; MUNOZ, JULIAN E.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P.. Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties. Medical Mycology, v. 52, n. 5, p. 544-548, 2014.

    Palavras-Chave: brazil; fungal diseases; fungi; mycoses; organs; lungs; chest; radiochemistry; labelling; pharmacology; kinetics; peptides


  • IPEN-DOC 23934

    FAINTUCH, BLUMA L. ; OLIVEIRA, ERICA A. ; MUNOZ, JULIAN E.; TRAVASSOS, LUIZ R.; TABORDA, CARLOS P.. Radiochemical pharmacokinetic profile of P10 peptide with antifungal properties. Medical Mycology, v. 52, n. 5, p. 1-5, 2014. DOI: 10.1093/mmy/myu024

    Abstract: Paracoccidioidomycosis (PCM) is a chronic granulomatous disease that is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis. It is endemic in some countries of Latin America and can cause a high-burden fungal infection with significant morbidity and mortality. The peptide P10, which demonstrates immune protection against experimental PCM, was radiolabeled with a radioisotope and evaluated in vivo. The radiolabeling was conducted to trace the pharmacokinetics of the molecule in principal organs and tissues. This was achieved with high radiochemical purity. Biodistribution and scintigraphic imaging showed fast blood clearance that was mainly renal; however, hepatobiliar excretion was also, withmarked uptake in cervical lymph nodes. This profile may be useful for the development of a prophylactic drug or vaccine for patients exposed to PCM.

    Palavras-Chave: fungal diseases; fungi; mycoses; organs; lungs; chest; radiochemistry; labelling; pharmacology; kinetics; peptides; brazil


  • IPEN-DOC 13040

    FAINTUCH, BLUMA L. ; TEODORO, RODRIGO; DUATTI, ADRIANO; MURAMOTO, EMIKO; FAINTUCH, SALOMAO; SMITH, CHARLES J.. Radiolabeled bombesin analog for prostate cancer diagnosis: preclinical studies. Nuclear Medicine and Biology, v. 35, p. 401-411, 2008.

    Palavras-Chave: cysteine; diagnosis; excretion; gastrin; kidneys; labelling; mice; neoplasms; pancreas; pertechnetates; prostate; radiochemistry; receptors; stability; technetium 99; tracer techniques; tumor cells; uptake


  • IPEN-DOC 24768

    OLIVEIRA, ERICA A. de ; FAINTUCH, BLUMA L. ; SEO, DANIELE ; BARBEZAN, ANGELICA B. ; FUNARI, ANA ; TARGINO, ROSELAINE C.; MORO, ANA M.. Radiolabeled GX1 peptide for tumor angiogenesis imaging. Applied Biochemistry and Biotechnology, p. 1-12, 2018. DOI: 10.1007/s12010-018-2700-z

    Abstract: Early and accurate detection of primary or metastatic tumors is of great value in staging, treatment management, and prognosis. Tumor angiogenesis plays an essential role in the growth, invasion, and metastatic spread of solid cancers, and so, is a promising approach for tumor imaging. The GX1 (CGNSNPKSC) peptide was identified by phage display library and has been investigated as a marker for human cancers. This study aims to evaluate the 99mTc-HYNIC-PEG4-c (GX1) as a biomarker for tumor imaging. Our results showed that GX1 specifically binds to tumor cells in vitro. SKMEL28 and MDA-MB231 cells achieved total binding peak at 60 min of incubation. For B16F10 and MKN45 cells, the total and specific binding were similar during all time points, while A549 cell line showed rapid cellular total uptake of the tracer at 30 min of incubation. Biodistribution showed low non-specific uptakes and rapid renal excretion. Melanoma tumors showed enhanced GX1 uptake in animal model at 60 min, and it was significantly blocked by cold peptide. The radiotracer showed tumor specificity, especially in melanomas that are highly vascularized tumors. In this sense, it should be considered in future studies, aiming to evaluate degree of angiogenesis, progression, and invasion of tumors.

    Palavras-Chave: bacteriophages; biological markers; melanomas; metastases; radiopharmaceuticals; technetium 99; tracer techniques; tumor cells


  • IPEN-DOC 17833

    FAINTUCH, BLUMA L. ; FERNANDEZ NUNEZ, GUSTAVO E.; TEODORO, RODRIGO; MORO, ANA M.; MENGATTI, JAIR . Radiolabeled nano-peptides show specificity for an animal model of human PC3 prostate cancer cells. Clinics, v. 66, n. 2, p. 327-336, 2011.

    Palavras-Chave: human populations; neoplasms; prostate; labelling; technetium 99; peptides


  • IPEN-DOC 18913

    OLIVEIRA, ERICA A.; FAINTUCH, BLUMA L. ; NUNEZ, EUTIMIO G.F.; MORO, ANA M.; NANDA, PRASANT K.; SMITH, CHARLES J.. Radiotracers for different angiogenesis receptors in a melanoma model. Melanoma Research, v. 22, n. 1, p. 45-53, 2012.

    Palavras-Chave: angiogenesis; melanomas; polypeptides; tracer techniques; technetium 99; diagnosis


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