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IPEN-DOC 25820
- SOUZA, CARLA D. de
; - NOGUEIRA, BEATRIZ R.
; - ROSTELATO, MARIA E.C.M.
. Review of the methodologies used in the synthesis gold nanoparticles by chemical reduction.
Journal of Alloys and Compounds,
v. 798,
p. 714-740,
2019.
DOI:
10.1016/j.jallcom.2019.05.153
Abstract: This paper presents a review in gold nanoparticles focusing on chemical reduction synthesis mechanisms.
We hope to aid students and researchers starting in the nanotechnology field by compiling the
most used synthesis methods, so they can select the ones that best suit them. The compiled information
in this paper approached the following methods: Turkevich Method; Synthesis with NaBH4 with/without
citrate; Seeding- Growth; Synthesis by Ascorbic Acid; Green Synthesis; Brust-Schiffrin; and synthesis
using other reducing agents. Papers that had clear synthesis information were selected for this work, but
that doesn't mean they were synthesis focused. Over 150 papers were analyzed. After compiling the
information for these papers, we can conclude that nanoscience is revolutionizing all the areas that are
applied to.
Palavras-Chave: gold; nanoparticles; synthesis; chemical reactions; reduction; nanotechnology; citrates; sodium compounds; ascorbic acid; surfactants; borohydrides; bromides; seeds
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IPEN-DOC 25206
- FREITAS, LUCAS F. de
; - VARCA, GUSTAVO H.C.
; - BATISTA, JORGE G. dos S.
; - LUGAO, ADEMAR B.
. An overview of the synthesis of gold nanoparticles using radiation technologies.
Nanomaterials,
v. 8,
n. 11,
2018.
DOI:
10.3390/nano8110939
Abstract: At a nano-level, optical properties of gold are unique and gave birth to an emerging
platform of nanogold-based systems for diverse applications, because gold nanoparticle properties
are tunable as a function of size and shape. Within the available techniques for the synthesis of gold
nanoparticles, the radiolytic synthesis allows proper control of the nucleation process without the need
for reducing agents, in a single step, combined or not with simultaneous sterilization. This review
details and summarizes the use of radiation technologies for the synthesis and preparation of gold
nanoparticles concerning fundamental aspects, mechanism, current pathways for synthesis and
radiation sources, as well as briefly outlines final applications and some toxicity aspects related to
nanogold-based systems.
Palavras-Chave: gold; nanoparticles; gamma radiation; electron beams; x-ray sources; radiolysis; nanotechnology; medicine; diagnostic uses; ionizing radiations
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IPEN-DOC 24361
- PASCUAL, LLUIS
;- CERQUEIRA-COUTINHO, CRISTAL
;- GARCIA-FERNANDEZ, ALBA
;- LUIS, BEATRIZ de
;- BERNARDES, EMERSON S.
; - ALBERNAZ, MARTA S.
;- MISSAILIDIS, SOTIRIS
;- MARTINEZ-MANEZ, RAMON
;- SANTOS-OLIVEIRA, RALPH
;- ORZAEZ, MAR
;- SANCENON, FELIX
. MUC1 aptamer-capped mesoporous silica nanoparticles for controlled drug delivery and radio-imaging applications. Nanomedicine: Nanotechnology, Biology, and Medicine, v. 13, n. 8, p. 2495-2505, 2017. DOI: 10.1016/j.nano.2017.08.006 Abstract: Mucin 1 (MUC1) is a cell surface protein overexpressed in breast cancer. Mesoporous silica nanoparticles (MSNs) loaded with safranin O, functionalized with aminopropyl groups and gated with the negatively charged MUC1 aptamer have been prepared (S1-apMUC1) for specific targeting and cargo release in tumoral versus non-tumoral cells. Confocal microscopy studies showed that the S1-apMUC1 nanoparticles were internalized in MDA-MB-231 breast cancer cells that overexpress MUC1 receptor with subsequent pore opening and cargo release. Interestingly, the MCF-10-A non-tumorigenic breast epithelial cell line that do not overexpress MUC1, showed reduced (S1- apMUC1) internalization. Negligible internalization was also found for S1-ap nanoparticles that contained a scrambled DNA sequence as gatekeeper. S2-apMUC1 nanoparticles (similar to S1-apMUC1 but loaded with doxorubicin) internalized in MDA-MB-231 cells and induced a remarkable reduction in cell viability. Moreover, S1-apMUC1 nanoparticles radio-labeled with 99mTc (S1-apMUC1-Tc) showed a remarkable tumor targeting in in vivo studies with MDA-MB-231 tumor-bearing Balb/c mice. © 2017 Elsevier Inc. All rights reserved.Palavras-Chave: radiopharmaceuticals; nanotechnology; neoplasms; tumor cells; nanoparticles; silica; porous materials; drugs
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IPEN-DOC 26645
- BONFIM, LETICIA
; - PASSOS, PRISCILA de Q.S.
; - GONÇALVES, KARINA de O.
;- COURROL, LILIA C.
;- SILVA, FLAVIA R. de O.
; - VIEIRA, DANIEL P.
. Microwave-mediated synthesis of iron-oxide nanoparticles for use in magnetic levitation cell cultures.
Applied Nanoscience,
v. 9,
n. 8,
p. 1707-1717,
2019.
DOI:
10.1007/s13204-019-00962-1
Abstract: The use of three-dimensional cell cultures has been widely used for efficacy and/or toxicity testing of compounds. One of the
most promising systems, based on magnetic levitation, is dependent on proper cell magnetization, achieved through adsorption
of iron-oxide nanoparticles on cell membranes. These particles must bare not only significant responses to magnetic
fields, but also a stable mechanism to attachment to cells. This work proposes a simple, one-pot synthesis method to produce
magnetite nanoparticles, using a Fe2+
precursor associated with amino acids under microwave heating, and successive
steps to confer positive charges to particles. X-ray diffraction could confirm Fe3O4
composition, and TEM analysis showed
cubic-like crystallites with less than 50 nm. Zeta-potential experiments showed that particles remained positively charged
(20.98 ± 0.28 mV) in physiological pH, suggesting ability to attach to (negatively charged) cell membranes, observed through
optical microscopy. Iron colloid was found to be non-cytotoxic in concentrations up to 8% in cell culture media. Finally,
human prostate cancer cells were cultured in 96-well plates using magnetic levitation and could be kept 8 days in culture.
The results showed a feasible way to produce spheroids relying on magnetic levitation, using a newly described method of
magnetic and cell adherent nanoparticle production.
Palavras-Chave: nanotechnology; iron oxides; microwave equipment; synthesis; nanoparticles; iron oxides; paramagnetism; toxicity; x-ray diffraction
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IPEN-DOC 22655
- SARCINELLI, MICHELLE A.
;- ALBERNAZ, MARTA de S.
;- SZWED, MARZENA
;- ISCAIFE, ALEXANDRE
;- LEITE, KATIA R.M.
;- JUNQUEIRA, MARA de S.
;- BERNARDES, EMERSON S.
; - SILVA, EMERSON O. da
;- TAVARES, MARIA I.B.
;- SANTOS-OLIVEIRA, RALPH
. Nanoradiopharmaceuticals for breast cancer imaging: development, characterization, and imaging in inducted animals. OncoTargets and Therapy, v. 9, p. 5847-5854, 2016. DOI: 10.2147/OTT.S110787 Abstract: Monoclonal antibodies as polymeric nanoparticles are quite interesting and endow this new drug category with many advantages, especially by reducing the number of adverse reactions and, in the case of radiopharmaceuticals, also reducing the amount of radiation (dose) administered to the patient. In this study, a nanoradiopharmaceutical was developed using polylactic acid (PLA)/polyvinyl alcohol (PVA)/montmorillonite (MMT)/trastuzumab nanoparticles labeled with technetium-99m (99mTc) for breast cancer imaging. In order to confirm the nanoparticle formation, atomic force microscopy and dynamic light scattering were performed. Cytotoxicity of the nanoparticle and biodistribution with 99mTc in healthy and inducted animals were also measured. The results from atomic force microscopy showed that the nanoparticles were spherical, with a size range of ~200–500 nm. The dynamic light scattering analysis demonstrated that over 90% of the nanoparticles produced had a size of 287 nm with a zeta potential of -14,6 mV. The cytotoxicity results demonstrated that the nanoparticles were capable of reaching breast cancer cells. The biodistribution data demonstrated that the PLA/PVA/MMT/trastuzumab nanoparticles labeled with 99mTc have great renal clearance and also a high uptake by the lesion, as ~45% of the PLA/PVA/MMT/trastuzumab nanoparticles injected were taken up by the lesion. The data support PLA/PVA/MMT/trastuzumab labeled with 99mTc nanoparticles as nanoradiopharmaceuticals for breast cancer imaging.Palavras-Chave: medicine; neoplasms; radiopharmaceuticals; nanotechnology; mammary glands; molecular structure; image processing; nanostructures; diagnosis; nuclear medicine
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IPEN-DOC 24861
- RUBIO-MARCOS, FERNANDO
;- DEL CAMPO, ADOLFO
;- ROJAS-HERNANDEZ, ROCIO E.
;- RAMIREZ, MARIOLA O.
;- PARRA, RODRIGO
;- ICHIKAWA, RODRIGO U.
; - RAMAJO, LEANDRO A.
;- BAUSA, LUISA E.
;- FERNANDEZ, JOSE F.
. Experimental evidence of charged domain walls in lead-free ferroelectric ceramics: light-driven nanodomain switching. Nanoscale, v. 10, n. 2, p. 705-715, 2018. DOI: 10.1039/c7nr04304j Abstract: The control of ferroelectric domain walls at the nanometric level leads to novel interfacial properties and functionalities. In particular, the comprehension of charged domain walls, CDWs, lies at the frontier of future nanoelectronic research. Whereas many of the effects have been demonstrated for ideal archetypes, such as single crystals, and/or thin films, a similar control of CDWs on polycrystalline ferroelectrics has not been achieved. Here, we unambiguously show the presence of charged domain walls on a leadfree (K,Na)NbO3 polycrystalline system. The appearance of CDWs is observed in situ by confocal Raman microscopy and second harmonic generation microscopy. CDWs produce an internal strain gradient within each domain. Specifically, the anisotropic strain develops a crucial piece in the ferroelectric domain switching due to the coupling between the polarization of light and the ferroelectric polarization of the nanodomain in the (K,Na)NbO3 ceramic. This effect leads to the tuning of the ferroelectric domain switching by means of the light polarization angle. Our results will help to understand the relevance of charged domain walls on the ferroelectric domain switching process and may facilitate the development of domain wall nanoelectronics by remote light control utilizing polycrystalline ferroelectrics.Palavras-Chave: nanoelectronics; nanotechnology; ferroelectric materials; domain structure; raman spectroscopy; polycrystals
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IPEN-DOC 27711
- NUNES, MARIO A.B.S.
;- MATOS, BRUNO R. de
; - SILVA, GLAURA G.
;- ITO, EDSON N.
;- MELO, TOMAS J.A. de
;- FECHINE, GUILHERMINO J.M.
. Hybrids nanocomposites based on a polymer blend (linear low-density polyethylene/poly(ethylene-co-methyl acrylate) and carbonaceous fillers (graphene and carbon nanotube). Polymer Composites, v. 42, n. 2, p. 661-677, 2021. DOI: 10.1002/pc.25856 Abstract: Interfacial or separate phase location of carbonaceous nanofillers (graphene and carbon nanotubes) in polymer blends with co-continuous phases can lead to double percolation behavior, significantly increasing rheological and electrical properties. The prediction of the morphology and the location of the nanofillers has been used as a tool to evaluate the proprieties of co-continuous polymer blends. This work aims to highlight the superior conductivity levels achieved using a low amount of carbon-based fillers, by the proper selection in a multiphase polymer matrix as a template for controlled dispersion and spatial distribution of the nanoparticles, offering a compromise between easy processability and enhanced performance. Here, two polymers (linear low-density polyethylene [LLDPE] and ethylene-co-methylacrylate [EMA]) and their cocontinuous blend (LLDPE/EMA) were loaded with nanofillers (few-layer graphene [FLG], few-walled carbon nanotube [FWCNT]) via continuous melt mixing in twin-screw extrusion, separate and simultaneously. It was observed that the addition of the nanofillers changed the co-continuity of the blend, with the probable migration of the nanofillers from the EMA (hydrophilic) phase to the LLDPE (hydrophobic) phase. Rheological percolation occurred preferentially in blends containing FWCNT and FLG/FWCNT. Electrical conductivity was observed in all compositions, with higher electrical conductivity being noticed in hybrids.Palavras-Chave: nanocomposites; hybridization; nanotechnology; polyethylenes; polymers; electric conductivity; carbon nanotubes; graphene
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IPEN-DOC 28603
- PERINI, ALINE A.
; - SHIRAISHI, GUILHERME F.
;- FREITAS, ANDERSON Z.
. Matching technological bid in smart cities initiatives: a case study of innovation fairs at research institute in Brazil.
Journal of Business and Economics,
v. 12,
n. 6,
p. 598-607,
2021.
DOI:
10.15341/jbe(2155-7950)/06.12.2021/003
Abstract: The main objective of this work was to present a general
framework of the technology roadmap from a central competence of Nuclear
and Energy Research Institute from Brazil. The approach provides a
structured to strength the join to market mechanism design to survive in
complex environment trends to shape the future. The technological
innovation impact measures depend from (1) quality of diversified
technology knowledge and (2) quality of diversified country industry
knowledge. From this big view picture, the Technology Transfer Office took
these two general dimensions of impact into account and divided them into
four (4) sub-categories that explain potential benefits and performance
results in areas such as: a) Current Projects and Programs, b) Patents, c)
Education and Teaching and d) Scientific Publications. The sampling
contemplated the big picture of performance related in National Management
Information System and a repository proper in response to institutional
performance growth and plans, programs and projects associated in
Innovation key indicators and policy disclosure. The taxonomy to
roadmapping innovation impact measure was centered in terms in two
potential fields to shape the future: i) Nuclear Research Reactors and/or
ii) Nanotechnology.
Palavras-Chave: nanotechnology; socio-economic factors; research reactors; appropriate technology
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IPEN-DOC 25208
- KATTI, K.V.
;- KHOOBCHANDANI, M.
;- THIPE, V.C.
;- AL-YASIRI, A.Y.
;- KATTI, K.K.
;- LOYALKA, S.K.
;- SAKR, T.M.
;- LUGAO, A.B.
. Prostate tumor therapy advances in nuclear medicine: green nanotechnology toward the design of tumor specific radioactive gold nanoparticles.
Journal of Radioanalytical and Nuclear Chemistry,
v. 318,
n. 3,
p. 1737-1747,
2018.
DOI:
10.1007/s10967-018-6320-4
Abstract: We report herein an innovative approach to prostate tumor therapy using tumor specific radioactive gold nanoparticles
(198Au) functionalized with Mangiferin (MGF). Production and full characterization of MGF-198AuNPs are described. In vivo
therapeutic efficacy of MGF-198AuNPs, through intratumoral delivery, in SCID mice bearing prostate tumor xenografts
are described. Singular doses of the nano-radiopharmaceutical (MGF-198AuNPs) resulted in over 85% reduction of tumor
volume as compared to untreated control groups. The excellent anti-tumor efficacy of MGF-198AuNPs are attributed to the
retention of over 90% of the injected dose within tumors for long periods of time. The retention of MGF-198AuNPs is also
rationalized in terms of the higher tumor metabolism of glucose which is present in the xanthanoid functionality of MGF.
Limited/no lymphatic drainage of MGF-198AuNPs to various non-target organs is an attractive feature presenting realistic
scope for the clinical translation of MGF-198AuNPs in for treating prostate cancers in human patients. The comparative
analysis of MGF-198AuNPs with other radioactive gold nanoparticles, functionalized either with epigallocatechin gallate
or the Gum Arabic, has revealed significantly superior tumoricidal characteristics of MGF-198AuNPs, thus corroborating
the importance of the tumor-avid glucose motif of MGF. Oncological implications of MGF-198AuNPs as a new therapeutic
agent for treating prostate and various solid tumors are presented.
Palavras-Chave: neoplasms; prostate; nuclear medicine; gold; nanoparticles; therapy; nanotechnology; radiation effects; brachytherapy
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IPEN-DOC 23219
- AL-YASIRI, A.Y.
;- KHOOBCHANDANI, M.
;- CUTLER, C.S.
;- WATKINSON, L.
;- CARMACK, T.
;- SMITH, C.J.
;- KUCHUK, M.
;- LOYALKA, S.K.
;- LUGAO, A.B.
; - KATTI, K.V.
. Mangiferin functionalized radioactive gold nanoparticles (MGF-198AuNPs) in prostate tumor therapy: green nanotechnology for production, in vivo tumor retention and evaluation of therapeutic efficacy. Dalton Transactions, 2017. DOI: 10.1039/c7dt00383h Abstract: We report here an innovative feature of green nanotechnology-focused work showing that mangiferin—a glucose functionalized xanthonoid, found in abundance in mango peels—serves dual roles of chemical reduction and in situ encapsulation, to produce gold nanoparticles with optimum in vivo stability and tumor specific characteristics. The interaction of mangiferin with a Au-198 gold precursor affords MGF-198AuNPs as the beta emissions of Au-198 provide unique advantages for tumor therapy while gamma rays are used for the quantitative estimation of gold within the tumors and various organs. The laminin receptor specificity of mangiferin affords specific accumulation of therapeutic payloads of this new therapeutic agent within prostate tumors (PC-3) of human prostate tumor origin induced in mice which overexpress this receptor subtype. Detailed in vivo therapeutic efficacy studies, through the intratumoral delivery of MGF-198AuNPs, show the retention of over 80% of the injected dose (ID) in prostate tumors up to 24 h. By three weeks post treatment, tumor volumes of the treated group of animals showed an over 5 fold reduction as compared to the control saline group. New opportunities for green nanotechnology and a new paradigm of using mangiferin as a tumor targeting agent in oncology for the application of MGF-198AuNPs in the treatment of cancer are discussed.Palavras-Chave: radioactive materials; nanoparticles; gold; therapy; prostate; neoplasms; nanotechnology
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A elaboração do projeto do RI do IPEN foi iniciado em novembro de 2013, colocado em operação interna em julho de 2014 e disponibilizado na Internet em junho de 2015. Utiliza o software livre Dspace, desenvolvido pelo Massachusetts Institute of Technology (MIT). Para descrição dos metadados adota o padrão Dublin Core. É compatível com o Protocolo de Arquivos Abertos (OAI) permitindo interoperabilidade com repositórios de âmbito nacional e internacional.
O gerenciamento do Repositório está a cargo da Biblioteca do IPEN. Constam neste RI, até o presente momento 20.950 itens que tanto podem ser artigos de periódicos ou de eventos nacionais e internacionais, dissertações e teses, livros, capítulo de livros e relatórios técnicos. Para participar do RI-IPEN é necessário que pelo menos um dos autores tenha vínculo acadêmico ou funcional com o Instituto. Nesta primeira etapa de funcionamento do RI, a coleta das publicações é realizada periodicamente pela equipe da Biblioteca do IPEN, extraindo os dados das bases internacionais tais como a Web of Science, Scopus, INIS, SciElo além de verificar o Currículo Lattes. O RI-IPEN apresenta também um aspecto inovador no seu funcionamento. Por meio de metadados específicos ele está vinculado ao sistema de gerenciamento das atividades do Plano Diretor anual do IPEN (SIGEPI). Com o objetivo de fornecer dados numéricos para a elaboração dos indicadores da Produção Cientifica Institucional, disponibiliza uma tabela estatística registrando em tempo real a inserção de novos itens. Foi criado um metadado que contém um número único para cada integrante da comunidade científica do IPEN. Esse metadado se transformou em um filtro que ao ser acionado apresenta todos os trabalhos de um determinado autor independente das variáveis na forma de citação do seu nome.