PATRICK JACK SPENCER

Resumo

Possui graduação em Ciências Biológicas pela Universidade Presbiteriana Mackenzie (1991), mestrado em Tecnologia Nuclear pela Universidade de São Paulo (1995) e doutorado em Tecnologia Nuclear pela Universidade de São Paulo (2000) tendo sido bolsista sandwich no US Army Medical Research Institute for Infeccious Diseases (98-99). É responsável pelo Biotério de criação e manutenção de animais de laboratório do IPEN. Tem experiência na área de Bioquímica, com ênfase em Proteínas, atuando principalmente nos seguintes temas: veneno, proteínas, bothrops, irradiação e miotoxina.(Texto extraído do Currículo Lattes em 22 dez. 2021)

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  • Capítulo IPEN-doc 28624
    Bradykinin-potentiating and related peptides from reptile venoms
    2021 - PIMENTA, DANIEL C.; SPENCER, PATRICK J.
    Evolution has provided venomous snakes with a vast arsenal of molecules able to interfere in several physiological processes. The ultimate role of these toxins, which are proteins or peptides, is to subdue the prey, although digestive functions should also be considered. Among these toxins, some are vasoactive peptides, which induce a drastic drop in blood pressure. This effect is attributed mostly to bradykinin-potentiating peptides, although other venom peptides have been shown to interfere with blood pressure. Bradykinin-potentiating peptides are modular in nature, with highly conserved motifs, and present high proline content, a pyroglutamate at the N-terminal and an IPP motif at the C-terminal. These peptides are potent and highly selective inhibitors of angiotensin-converting enzyme, a crucial molecule for blood pressure regulation, and display K i s as low as 8 nM. Besides the enzyme inhibition, some of these peptides might cross the cell membrane, interfering in the production of nitric oxide, another modulator of blood vessel tonus. Evolution frequently results in physiological redundancies. Such a fact is reflected by the occurrence of another class of blood pressure–modulating toxins. C-type natriuretic peptides can be considered as such. Apparently, these toxins increase guanylate cyclase levels, inducing vasorelaxation. These peptides are being considered as drug leads for congestive heart failure. While C-type natriuretic peptides are still under investigation as potential drugs, bradykinin-potentiating peptide–derived drugs are the boldest example of the use of a deleterious “toxin” as a building block for a cheap drug that benefits a huge number of human beings.
  • Capítulo IPEN-doc 16161
    Advances in rabies laboratory diagnosis in Brazil
    2010 - CAPORALE, GRACIANE M.M.; PEIXOTO, ZELIA M.P.; CHAVES, LUCIANA B.; CARRIERI, MARIA L.; SCHEFFER, KARIN C.; ACHKAR, SAMIRA M.; CARNIELI JUNIOR, PEDRO; SPENCER, PATRICK; VASSAO, RUTH C.; SILVA, ANDREA de C.R. da