NANCI DO NASCIMENTO
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Artigo IPEN-doc 06836 Gabaergic-benzodiazepine system is involved in the crotoxin-induced anxiogenic effect2000 - MOREIRA, E.G.; NASCIMENTO, N.; ROGERO, J.R.; VASSILIEFF, V.S.The behavioral effects of crotoxin (CTX), the major component of Crotalus durissus terrificus venom, were studied in rats submitted to the open field, holeboard, and social interaction tests. CTX (100, 250, and 500 Ī¼g/kg, IP) was administered 2 h before the tests. In the open field, CTX reduced ambulation (250 Ī¼g/kg) and rearing (250 and 500 Ī¼g/kg) and increased grooming (100 and 250 Ī¼g/kg) and freezing (250 Ī¼g/kg). In the holeboard and social interaction, all the CTX doses evaluated decreased, respectively, head dip and head dipping, and social interaction time. The CTX-induced behavioral alterations could be attributed to its neuromuscular transmission blockade, but this possibility was ruled out because CTX (250 and 500 Ī¼g/kg, IP, 2 h before the rotarod test) was unable to modify the rotarod performance of rats. The involvement of the benzodiazepine receptor in the CTX-induced behavioral alterations was investigated through the pretreatment (30 min before the tests, IP) of the animals with diazepam (1.2 mg/kg), or flumazenil (4 and 10 mg/kg). Both diazepam and flumazenil antagonized the CTX-induced behavioral alterations in the open field, holeboard, and social interaction tests. This study demonstrated that: (1) CTX is an anxiogenic compound; and (2) the gabaergic-benzodiazepine system may play a role in the CTX-induced anxiogenic effect.