NANCI DO NASCIMENTO
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Artigo IPEN-doc 14485 Effect of gamma radiation on the structural and biological properties of angiotensin II2008 - NARDI, DANIELA T.; CASARE, MURILO S.; TEIXEIRA, LUIS G.D.; NASCIMENTO, NANCI; NAKAIE, CLOVIS R.Artigo IPEN-doc 14476 Young ovine death during hyperimmunization: crotalic envenomation or copper toxicosis?2008 - FERREIRA JUNIOR, R.S.; NASCIMENTO, N.; COUTO, R.; ALVES, J.B.; MEIRA, D.A.; BARRAVIERA, B.Artigo IPEN-doc 14475 Immunological assessment of mice hyperimmunized with native and cobalt-60-irradiated bothrops venoms2005 - FERREIRA JUNIOR, R.S.; NASCIMENTO, N.; MARTINEZ, J.C.; ALVES, J.B.; MEIRA, D.A.; BARRAVIERA, B.ELISA was used to evaluate, accompany, and compare the humoral immune response of Swiss mice during hyperimmunization with native and Cobalt60-irradiated (60Co) venoms of Bothrops jararaca, Bothrops jararacussu and Bothrops moojeni. Potency and neutralization were evaluated by in vitro challenges. After hyperimmunization, immunity was observed by in vivo challenge, and the side effects were assessed. The animals immunization with one LD50 of each venom occurred on days 1, 15, 21, 30, and 45, when blood samples were collected; challenges happened on the 60th day. Results showed that ELISA was efficient in evaluating, accompanying and comparing mouse immune response during hyperimmunization. Serum titers produced with natural venom were similar to those produced with irradiated venom. Immunogenic capacity was maintained after 60Coirradiation. The sera produced with native venom showed neutralizing potency and capacity similar to those of the sera produced with irradiated venom. All antibodies were able to neutralize five LD50 from these venoms. Clinical alterations were minimum during hyperimmunization with irradiated venom, however, necrosis and death occurred in animals inoculated with native venom.Artigo IPEN-doc 14474 Immunization with native and cobalt 60-irradiated Crotalus durissus terrificus venom in swiss mice: assessment of the neutralizing potency of antisera2005 - FERREIRA JUNIOR, R.S.; NASCIMENTO, N.; MARTINEZ, J.C.; ALVES, J.B.; MEIRA, D.A.; BARRAVIERA, B.Artigo IPEN-doc 13066 Tissue distribution in mice of BPP 10c, a potent proline-rich anti-hypertensive peptide of Bothrops jararaca2008 - SILVA, CARLOS A.; PORTARO, FERNANDA C.V.; FERNANDES, BEATRIZ L.; IANZER, DANIELLE A.; GUERREIRO, JULIANO R.; GOMES, CLAUDIANA L.; KONNO, KATSUHIRO; SERRANO, SOLANGE M.T.; NASCIMENTO, NANCI; CAMARGO, ANTONIO C.M.Artigo IPEN-doc 13015 Laboratory evaluation of young ovines inoculated with natural or sup(60)Co-irradiated Crotalus durissus terrificus venom during hyperimmunization process2006 - FERREIRA JUNIOR, R.S.; NASCIMENTO, N.; COUTO, R.; ALVES, J.B.; MEIRA, D.A.; BARRAVIERA, B.Laboratory profile of young ovines was studied in order to evaluate and compare their antiserum production from natural and Cobalt-60 irradiated Crotalus durissus terrificus (C.d.t.) venoms. The parameters analyzed included complete blood count, and urea, creatinine, aspartate aminotransferase, total proteins, albumin and globulin serum measurements. Three groups of six animals each were used. Group 1 (G1) received natural C.d.t. venom; Group 2 (G2) received irradiated C.d.t. venom; and Group 3 (G3) was used as control and did not receive venom, only adjuvants, using seven venom inoculations. During the experimental period, animals were fortnightly weighed. According to clinical and weight evaluation, sheep in post-weaning phase showed no changes in their physiological profiles but had excellent weight gain. The parameters analyzed were not statistically different (p<5%) among the groups tested. The hyperimmunization process was successfully accomplished with the production of specific antibodies against Crotalus durissus terrificus venom. Results bring a new possibility of utilizing ovines in the commercial production of anticrotalic serum, which may be used to treat human and animal envenomation. Its production cost may be reduced by subsequent use of hyperimmunized sheep for human consumption.Artigo IPEN-doc 12286 Efeitos da radiacao gama no comportamento mecanico e na calcificacao do pericardio bovino fixado com glutaraldeido2007 - BAUCIA, JOSE A.; LEAL NETO, RICARDO M.; ROGERO, JOSE R.; NASCIMENTO, NANCI do; REYES, CARMEM A.C.Artigo IPEN-doc 11620 Immune response against irradiated with sup(60)Co gamma-rays2006 - BAPTISTA, J.A.; SPENCER, P.J.; OLIVEIRA, J.E.; CESARE, M.S.; NASCIMENTO, N.Artigo IPEN-doc 09897 Effects of gamma rays on the immunogenicity (IgG types) of ovalbumin2004 - BAPTISTA, J.A.; SPENCER, P.J.; AROEIRA, L.G.S.; CASARE, M.S.; NASCIMENTO, N.Artigo IPEN-doc 09896 Effects of sup(60)Co radiation on the molecular structure of crotamine2004 - CASARE, M.S.; BAPTISTA, J.A.; SPENCER, P.J.; NASCIMENTO, N.