NANCI DO NASCIMENTO
39 resultados
Resultados de Busca
Agora exibindo 1 - 10 de 39
Artigo IPEN-doc 27224 Paratrygon aiereba irradiated anti-mucus serum reduce edematogenic activity induced in experimental model2020 - THOMAZI, GABRIELA O.C.; COSTA, ANDREA da; RODRIGUES, JAQUELINE P.; ALVES, GLAUCIE J.; PREZOTTO NETO, JOSE P.; TURIBIO, THOMPSON de O.; ROCHA, ANDRE M.; AIRES, RAQUEL da S.; SEIBERT, CARLA S.; SPENCER, PATRICK J.; GALISTEO JUNIOR, ANDRES J.; ANDRADE JUNIOR, HEITOR F. de; NASCIMENTO, NANCI doAccidents by freshwater stingrays are common in northern Brazil, there is no specific therapy for high morbidity and local tissue destruction. The irradiation of venoms and toxins by ionizing radiation has been used to produce appropriate immunogens for the production of antisera. We planned to study the efficacy of stinging mucus irradiation in the production of antisera, with serum neutralization assays of edematogenic activity and quantification of cytokines performed in animal models of immunization with native and irradiated mucus of Paratrygon aiereba, a large freshwater stingray. Antiserum potency and its cross-reactivity with mucus from other freshwater stingrays were detected by ELISA. Immunization models demonstrated the ability to stimulate a strong humoral response with elevated levels of serum IgG detectable by ELISA, and both native and irradiated mucus were immunogenic and capable of recognizing mucus proteins from other freshwater neotropical stingrays. Mucus P. aiereba causes cellular and humoral adaptive immune responses in cells of immunized mice producing antibodies and cytokines such as TNF-α, IL-6 and IL-17. Rabbit antisera immunized with mucus from P. aiereba irradiated at 2 kGy showed a significant reduction of mucus-induced edematogenic activity in mice. Our data suggest that the use of antisera against freshwater stingray mucus show the possibility of specific therapy for these accidents.Artigo IPEN-doc 21107 Comparative nephrotoxicity of native or Co-60 gamma rays irradiated crotoxin in mice2015 - ROCHA, ANDRE M.; ROCHA, JOSEFA M.N.; MAGALHAES FILHO, ASTERIO S.; ALVES, GLAUCIE J.; AIRES, RAQUEL da S.; TURIBIO, THOMPSON O.; THOMAZI, GABRIELA O.C.; SPENCER, PATRICK J.; NASCIMENTO, NANCI doArtigo IPEN-doc 20886 New insights into the structural characteristics of irradiated crotamine2015 - OLIVEIRA, KARINA C.; SPENCER, PATRICK J.; FERREIRA JUNIOR, RUI S.; NASCIMENTO, NANCICapítulo IPEN-doc 02923 Comparative studies of antisera against different toxins1996 - NASCIMENTO, N.; SPENCER, P.J.; PAULA, R.A.; ANDRADE JUNIOR, H.F.; ROGERO, J.R.Resumo IPEN-doc 04676 Structural and biological alterations of crotoxin following irradiation in the presence of thiol groups1997 - NASCIMENTO, N.; ANDRIANI, E.P.; SPENCER, P.J.; ROGERO, J.R.Resumo IPEN-doc 05091 Effects of sup(60)Co gamma radiation on the antigenic and immunogenic properties of bothorops jararacussu venom1996 - SPENCER, P.J.; NASCIMENTO, N.; ROGERO, J.R.Resumo IPEN-doc 04685 Biochemical and immunological characterization of the main products of crotoxin irradiation1996 - NASCIMENTO, N.; CLISSA, P.B.; SPENCER, P.J.; ANDRADE JUNIOR, H.F.; KAISER, I.I.; ROGERO, J.R.Resumo IPEN-doc 02801 Biochemical and immunogenic properties of sup(60)Co irradiated bothrops jararacussu venom1996 - SPENCER, P.J.; NASCIMENTO, N.; ROGERO, J.R.Resumo IPEN-doc 06074 Immunogenicidade comparativa de veneno de bothrops jararacussu nativo e submetido a radiacao gama1995 - SPENCER, P.J.; PAULA, R.A. de; NASCIMENTO, N.; OLIVEIRA LIMA, M.; ROGERO, J.R.Resumo IPEN-doc 05878 Structural biological and immunological alterations of crotoxin following irradiation in the presence of thiol groups1995 - ANDRIANI, E.P.; SPENCER, P.J.; NASCIMENTO, N.; CLISSA, P.B.; ROGERO, J.R.