MARGATHO, RAFAEL O.MASSOCO, CRISTINA de O.CALEFI, ATILIO S.CRUZ, DANIEL S.G.SANDINI, THAISA M.ALVES, GLAUCIE J.FLORIO, JORGE C.PALERMO-NETO, JOAO2018-02-062018-02-062017MARGATHO, RAFAEL O.; MASSOCO, CRISTINA de O.; CALEFI, ATILIO S.; CRUZ, DANIEL S.G.; SANDINI, THAISA M.; ALVES, GLAUCIE J.; FLORIO, JORGE C.; PALERMO-NETO, JOAO. Beta-adrenergic blockade decreases the neuroimmune changes in mice induced by cohabitation with an ehrlich tumor-bearing cage mate. <b>Neuroimmunomodulation</b>, v. 24, n. 1, p. 40-53, 2017. DOI: <a href="https://dx.doi.org/10.1159/000477938">10.1159/000477938</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28448.1021-7401http://repositorio.ipen.br/handle/123456789/28448Objectives: Cohabitation with Ehrlich tumor-bearing (ETB) mice induced behavioral, neurochemical, hormonal, and immune effects in the conspecifics as a consequence of stressinduced activation of the sympathetic nervous system (SNS) with catecholamine release. In the current study, the nonspecific β-AR blocker d,l -propranolol and the specific β 2 -AR blocker ICI-118.551 were employed as pharmacological tools to assess the extent to which catecholamines participated in the effects induced by cohabitation with ETB mice. Methods: Two experiments were performed, 1 with d,l -propranolol treatment and the other with ICI-118.551. One mouse in the experimental group was called the “companion of the sick partner” (CSP) since it was forced to live in the same cage with 2 (experiment 1) or 1 (experiment 2) cage mate that had been i.p. injected with 5 × 10 6 Ehrlich tumor cells. Results: The d,l -propranolol treatment, but not the ICI- 118.551 treatment, attenuated the effects of cohabitation with 2 ETB mice on both open-field behavior and the hypothalamic levels and turnover rate of norepinephrine. The 2 β-AR blockers were unable to change the serum corticosterone levels and adrenal weights of the CSP mice; however, these drugs abrogated the effects of cohabitation on neutrophil oxidative burst and phagocytosis. Finally, an increase in the 5-HT turnover rate was observed in the olfactory bulb of CSP mice compared to their respective controls, an effect that was not modified by β-AR blockade. Conclusion: These results confirm and strengthen our hypothesis that the SNS is involved in the effects induced by cohabitation with ETB mice and point towards β 2 -AR participation in the immune effects analyzed.40-53openAccesscatecholaminesstressesdrugsserotoninneutrophilsneoplasmsArtigo de periódico12410.1159/00047793828.12