VILELA, HANDIALLY S.TRINCA, RAFAEL B.ALVES, TARSILA V.M.SCARAMUCCI, TAISSAKAE, LETICIA O.MARIANO, FLAVIA S.GIANNINI, MARCELOSILVA, FLAVIA R.O.BRAGA, ROBERTO R.2024-04-042024-04-042024VILELA, HANDIALLY S.; TRINCA, RAFAEL B.; ALVES, TARSILA V.M.; SCARAMUCCI, TAIS; SAKAE, LETICIA O.; MARIANO, FLAVIA S.; GIANNINI, MARCELO; SILVA, FLAVIA R.O.; BRAGA, ROBERTO R. Effect of a calcium silicate cement and experimental glass ionomer cements containing calcium orthophosphate particles on demineralized dentin. <b>Clinical Oral Investigations</b>, v. 28, n. 1, p. 1-11, 2024. DOI: <a href="https://dx.doi.org/10.1007/s00784-024-05489-6">10.1007/s00784-024-05489-6</a>. Disponível em: https://repositorio.ipen.br/handle/123456789/48014.1432-6981https://repositorio.ipen.br/handle/123456789/48014Objective: The study aims to evaluate the effect of a glass ionomer cement (GIC; Fuji 9 Gold Label, GC) with added calcium orthophosphate particles and a calcium silicate cement (CSC; Biodentine, Septodont) regarding ion release, degradation in water, mineral content, and mechanical properties of demineralized dentin samples. Methods: GIC, GIC + 5% DCPD (dicalcium phosphate dihydrate), GIC + 15% DCPD, GIC + 5% β-TCP (tricalcium phosphate), GIC + 15% β-TCP (by mass), and CSC were evaluated for Ca2+/Sr2+/F− release in water for 56 days. Cement mass loss was evaluated after 7-day immersion in water. Partially demineralized dentin disks were kept in contact with materials while immersed in simulated body fluid (SBF) at 37 °C for 56 days. The “mineral-to-matrix ratio” (MMR) was determined by ATR-FTIR spectroscopy. Dentin hardness and elastic modulus were obtained by nanoindentation. Samples were observed under scanning and transmission electron microscopy. Data were analyzed by ANOVA/Tukey test (α = 0.05). Results: Ca2+ release from CSC and GIC (μg/cm2) were 4737.0 ± 735.9 and 13.6 ± 1.6, respectively. In relation to the unmodified GIC, the addition of DCPD or β-TCP increased ion release (p < 0.001). Only the dentin disks in contact with CSC presented higher MMR (p < 0.05) and mechanical properties than those restored with a resin composite used as control (p < 0.05). Mass loss was similar for GIC and CSC; however, the addition of DCPD or β-TCP increased GIC degradation (p < 0.05). Conclusion: Despite the increase in ion release, the additional Ca2+ sources did not impart remineralizing capability to GIC. Both unmodified GIC and CSC showed similar degradation in water. Clinical relevance: CSC was able to promote dentin remineralization.1-11openAccessdemineralizationdentinbone tissuescalcium silicatescalcium phosphatesglasscementsArtigo de periódico12810.1007/s00784-024-05489-685.789.00