ROSTELATO, MARIA E.C.M.RELA, PAULO R.ZEITUNI, CARLOS A.FEHER, ANSELMOMANZOLI, JOSE E.MOURA, JOAO A.MOURA, EDUARDO S.SILVA, CONSTANCIA P.G.2014-07-152014-07-302014-07-152014-07-302008ROSTELATO, MARIA E.C.M.; RELA, PAULO R.; ZEITUNI, CARLOS A.; FEHER, ANSELMO; MANZOLI, JOSE E.; MOURA, JOAO A.; MOURA, EDUARDO S.; SILVA, CONSTANCIA P.G. Development and production of radioactive sources used for cancer treatment in Brazil. <b>Nukleonika</b>, v. 53, p. S99-S103, 2008. Disponível em: http://repositorio.ipen.br/handle/123456789/4934.0029-5922http://repositorio.ipen.br/handle/123456789/4934The number of cancer patients in Brazil is increasing and part of the patients are submitted to brachytherapy treatment using iridium-192 wire and iodine-125 radioactive seeds. The Nuclear Energy Research Institute established a programme to produce iridium-192 wire and iodine-125 radioactive seeds. With the purpose of settling a laboratory for iridium-192 sources production, a wire activation method was developed and a hot cell for the wire manipulation, quality assurance and packaging was built. The iodine-125 seeds consist of a welded titanium capsule containing iodine-125 adsorbed onto a silver rod. Concerning the setup of the local production, the following activities were carried out: superficial treatment of the silver rod, development of a process to absorb the iodine in the silver rod, welding methodology to seal the seeds, leakage and contamination test and source activity measurement.S99-S103openAccessirradiation devicesionizing radiationsbrachytherapyneoplasmsbraziliodine 125iridium 192radiation sourcesArtigo de periódico53https://orcid.org/0000-0002-5054-0799https://orcid.org/0000-0002-7303-6720https://orcid.org/0000-0003-2943-6097