BORRELY, S.I.REDÍGOLO, M.M.VILLARD, B.D.LEBRE, D.T.TOMINAGA, F.K.2022-12-202022-12-202022BORRELY, S.I.; REDÍGOLO, M.M.; VILLARD, B.D.; LEBRE, D.T.; TOMINAGA, F.K. Degradation and toxicity of amoxicillin after electron beam irradiation. <b>Brazilian Journal of Radiation Sciences</b>, v. 10, n. 3B, p. 1-8, 2022. DOI: <a href="https://dx.doi.org/10.15392/2319-0612.2022.1894">10.15392/2319-0612.2022.1894</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/33499.2319-0612http://repositorio.ipen.br/handle/123456789/33499A recent and growing concern in environmental studies is the presence of antibiotics in wastewater, which contributes to antimicrobial resistance building. Amoxicillin, according to the World Health Organization, is one of the most consumed antibiotics worldwide, for being a first line therapy for common infections. Among several drug degradation methodologies, electron beam irradiation (EBI) is presented as an efficient and green treatment. This work presents data on amoxicillin degradation via EBI. Degradation rate was evaluated by LC/MS-MS, carbon removal efficiency was evaluated by TOC and ecotoxicity assays were performed employing Vibrio fischeri. Chromatographic results indicate an efficiency removal of 97.65% at 0.75 kGy and concentration below the limit of detection with increasing absorbed dose. Low mineralization (up to 10%) was achieved at 3.0 kGy. Regarding toxicity, approximately 81% of toxicity removal was obtained at 0.75 kGy and a decrease in efficiency was achieved with higher doses. In conclusion, results indicate the low doses (0.75 kGy) as most effective for drug removal employing EBI.1-8openAccessantibioticswaste waterwater pollutiontoxicitydecompositiondetoxificationelectron beamsionizing radiationsirradiationArtigo de periódico3B1010.15392/2319-0612.2022.1894https://orcid.org/0000-0002-9692-5539Sem PercentilSem Percentil CiteScore