REZENDE, SANDRA B.RIBEIRO, MARTHA S.NUNEZ, SILVIA C.GARCIA, VALDIR G.MALDONADO, EDISON P.2014-07-152014-07-302014-07-152014-07-302007REZENDE, SANDRA B.; RIBEIRO, MARTHA S.; NUNEZ, SILVIA C.; GARCIA, VALDIR G.; MALDONADO, EDISON P. Effects of a single near-infrared laser treatment on cutaneous wound healing: biometrical and histological study in rats. <b>Journal of Photochemistry and Photobiology B: Biology</b>, v. 87, p. 145-153, 2007. DOI: <a href="https://dx.doi.org/10.1016/j.jphotobiol.2007.02.005">10.1016/j.jphotobiol.2007.02.005</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/5246.1011-1344http://repositorio.ipen.br/handle/123456789/5246Background: Low intensity laser therapy has been recommended to support the cutaneous repair; however, so far studies do not have evaluated the tissue response following a single laser treatment. This study investigated the effect of a single laser irradiation on the healing of full-thickness skin lesions in rats. Methods: Forty-eight male rats were randomly divided into three groups. One surgical lesion was created on the back of rats using a punch of 8 mm in diameter. One group was not submitted to any treatment after surgery and it was used as control. Two energy doses from an 830-nm near-infrared diode laser were used immediately post-wounding: 1.3 J cm-2 and 3 J cm-2. The laser intensity 53 mW cm-2 was kept for both groups. Biometrical and histological analyses were accomplished at days 3, 7 and 14 post-wounding. Results: Irradiated lesions presented a more advanced healing process than control group. The dose of 1.3 J cm-2 leaded to better results. Lesions of the group irradiated with 1.3 J cm-2 presented faster lesion contraction showing quicker re-epithelization and reformed connective tissue with more organized collagen fibers. Conclusions: Low-intensity laser therapy may accelerate cutaneous wound healing in a rat model even if a single laser treatment is performed. This finding might broaden current treatment regimens.145-153openAccessskinrepairwoundslaser radiationgallium arsenideslow dose irradiationtherapeutic usestherapyArtigo de periódico8710.1016/j.jphotobiol.2007.02.005https://orcid.org/0000-0002-4203-1134