ANTUNES, PAULA C.G.SIQUEIRA, PAULO de T.D.SHORTO, JULIAN M.B.YORIYAZ, HELIO2023-04-262023-04-262023ANTUNES, PAULA C.G.; SIQUEIRA, PAULO de T.D.; SHORTO, JULIAN M.B.; YORIYAZ, HELIO. A versatile physical phantom design and construction for I-125 dose measurements and dose-to-medium determination. <b>Brachytherapy</b>, v. 22, n. 1, p. 80-92, 2023. DOI: <a href="https://dx.doi.org/10.1016/j.brachy.2022.10.005">10.1016/j.brachy.2022.10.005</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/34007.1538-4721http://repositorio.ipen.br/handle/123456789/34007PURPOSE: In this paper we present a phantom designed to provide conditions to generate set of “true” independent reference data as requested by TG-186, and mitigating the scarcity of experimental studies on brachytherapy validation. It was used to perform accurate experimental measurements of dose of 125I brachytherapy seeds using LiF dosimeters, with the objective of experimentally validating Monte Carlo (MC) calculations with model-based dose calculation algorithm (MBDCA). In addition, this work intends to evaluate a methodology to convert the experimental values from LiF into dose in the medium. METHODS AND MATERIALS: The proposed PMMA physical phantom features cavities to insert a LiF dosimeter and a 125I seed, adjusted in different configurations with variable thickness. Monte Carlo calculations performed with MCNP6.2 code were used to score the absorbed dose in the LiF and the dose conversion parameters. A sensitivity analysis was done to verify the source of possible uncertainties and quantify their impact on the results. RESULTS: The proposed phantom and experimental procedure developed in this work provided precise dose data within 5.68% uncertainty (k = 1). The achieved precision made it possible to convert the LiF responses into absorbed dose to medium and to validate the dose conversion factor methodology. CONCLUSIONS: The proposed phantom is simple both in design and as in its composition, thus achieving the demanded precision in dose evaluations due to its easy reproducibility of experimental setup. The results derived from the phantom measurements support the dose conversion methodology. The phantom and the experimental procedure developed here can be applied for other materials and radiation sources.80-92openAccessbiological modelsphantomsbrachytherapyiodine 125seedslithium fluoridesmonte carlo methodArtigo de periódico12210.1016/j.brachy.2022.10.0050000-0003-4023-236X0000-0003-4817-52750000-0003-2281-5756https://orcid.org/0000-0003-4023-236Xhttps://orcid.org/0000-0003-4817-527518.748.00