SILVA, G.S.CAMILLO, M.A.P.HIGA, O.Z.PUGLIESI, R.FERNANDES, E.G.R.QUEIROZ, A.A.A.2014-11-172014-11-182015-04-012014-11-172014-11-182015-04-01SILVA, G.S.; CAMILLO, M.A.P.; HIGA, O.Z.; PUGLIESI, R.; FERNANDES, E.G.R.; QUEIROZ, A.A.A. Synthesis and biological evaluation of boronated polyglycerol dendrimers as potential agent for neutron capture therapy. In: INTERNATIONAL NUCLEAR ATLANTIC CONFERENCE; ENCONTRO NACIONAL DE APLICACOES NUCLEARES, 7th, ago. 28 - set. 2, 2005, Santos, SP. <b>Anais...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/18237.http://repositorio.ipen.br/handle/123456789/18237In this work, the polyglycerol dendrimer (PGLD) generation 5 was used to obtain a boronated macromolecule for boron neutron capture therapy (BNCT). The PGLD dendrimer was synthesized by the ring opening polymerization of deprotonated glycidol using polyglycerol as core functionality in a step-growth processes denominated divergent synthesis. The PGLD dendritic structure was confirmed by gel permeation chromatography (GPC), nuclear magnetic resonance (1 H-NMR, 13C-NMR) and matrix assisted laser desorption/ionization (MALDI-TOF) techniques. The synthesized dendrimer presented low dispersion in molecular weights (Mw/Mn = 1.05) and a degree of branching of 0.82, which characterize the polymer dendritic structure. Quantitative neutron capture radiography (QNCR) was used to investigate the boron-10 enrichment of the polyglycerol dendrimer. The in vitro citotoxicity to Chinese hamster ovary cells of 10B-PGLD dendrimer indicate lower cytotoxicity, suggesting that the macromolecule is a biocompatible material.openAccessboron 10compatibilitygel permeation chromatographyglycerolhamstershistological techniquesmolecular weightneutron capture therapynuclear magnetic resonancepolymerstoxicityTexto completo de evento