CABRAL, FERNANDA V.RIBEIRO, MARTHA S.2020-03-252020-03-25CABRAL, FERNANDA V.; RIBEIRO, MARTHA S. Methylene blue-mediated photodynamic therapy on cutaneous leishmaniasis: an in vitro and in vivo study. In: INTERNATIONAL PHOTODYNAMIC ASSOCIATION WORLD CONGRESS, 17th, June 28 - July 4, 2019, Cambridge, Massachusetts, USA. <b>Abstract...</b> DisponÃvel em: http://repositorio.ipen.br/handle/123456789/30951.http://repositorio.ipen.br/handle/123456789/30951Cutaneous leishmaniasis (CL) is a neglected disease, which promotes destructive lesions. Difficulties in treatment are related to resistance and toxicity. Methylene blue-mediated photodynamic therapy (MB-PDT) has emerged as a promising treatment considering low cost and no reports about resistance. We evaluated MB-PDT on Leishmania amazonensis in vitro and in vivo using a red LED at different fluences. Our results demonstrated that the best fluence in vitro was not effective in vivo, and a higher dose was necessary to provide better responses in mice. This study reinforces the idea that a well-planned protocol is necessary for a successful MB-PDT on CL.openAccessMethylene blue-mediated photodynamic therapy on cutaneous leishmaniasisResumo de eventos cientÃficos0000-0002-4203-1134https://orcid.org/0000-0002-4203-1134