MARANHO, L.A.FONTES, M.K.KAMIMURA, A.S.S.NOBRE, C.R.MORENO, B.B.PUSCEDDU, F.H.CORTEZ, F.S.LEBRE, D.T.MARQUES, J.R.ABESSA, D.M.S.RIBEIRO, D.A.PEREIRA, C.D.S.2018-02-072018-02-072017MARANHO, L.A.; FONTES, M.K.; KAMIMURA, A.S.S.; NOBRE, C.R.; MORENO, B.B.; PUSCEDDU, F.H.; CORTEZ, F.S.; LEBRE, D.T.; MARQUES, J.R.; ABESSA, D.M.S.; RIBEIRO, D.A.; PEREIRA, C.D.S. Exposure to crack cocaine causes adverse effects on marine mussels Perna perna. <b>Marine Pollution Bulletin</b>, v. 123, n. 1-2, p. 410-414, 2017. DOI: <a href="https://dx.doi.org/10.1016/j.marpolbul.2017.08.043">10.1016/j.marpolbul.2017.08.043</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28460.0025-326Xhttp://repositorio.ipen.br/handle/123456789/28460Our study aimed to evaluate crack cocaine effects in different life stages of the marine mussel Perna perna. For this purpose, fertilization rate, embryo-larval development, lysosomal membrane stability and DNA strand breaks were assessed. Effect concentrations in gametes and in larval development were found after 1 h (IC50 =23.53 mg·L−1) and 48 h (IC50 =16.31 mg·L−1), respectively. The highest tested concentration showing no acute toxicity (NOEC) was 10 mg·L−1, while the lowest observed effect concentration (LOEC) was 20 mg·L−1. NOEC concerning embryo-larval development was 0.625 mg·L−1, while the LOEC was 1.25 mg·L−1. Cyto-genotoxic effects were evidenced in mussels exposed to crack cocaine concentrations ranging from 5 to 500 μg·L−1. Our results report the first data on effects of an illicit drug to marine organisms and should encourage further ecotoxicological studies of these contaminants of emerging concern in coastal ecosystems.410-414openAccesscocaineaquatic ecosystemsaquatic organismsmusselsbioassaytoxicitycell cyclewater pollutionpollutantschemical wastesArtigo de periódico1-212310.1016/j.marpolbul.2017.08.04382.25