BOIANI, N.F.TOMINAGA, F.K.BORRELY, S.I.2022-12-202022-12-202022BOIANI, N.F.; TOMINAGA, F.K.; BORRELY, S.I. Toxicity removal of pharmaceuticals mixtures through electron beam irradiation. <b>Brazilian Journal of Radiation Sciences</b>, v. 10, n. 3B, p. 1-11, 2022. DOI: <a href="https://dx.doi.org/10.15392/2319-0612.2022.1838">10.15392/2319-0612.2022.1838</a>. DisponÃvel em: http://repositorio.ipen.br/handle/123456789/33511.2319-0612http://repositorio.ipen.br/handle/123456789/33511Contamination of the aquatic environment by pharmaceuticals is becoming a global phenomenon of growing concern. Pharmaceuticals are partially metabolized, resulting in the excretion and release of residual into sewage, unaltered or metabolites. The wastewater treatment plants are not designed to eliminate these compounds, leading the residues into the aquatic environment. Besides, pharmaceuticals are not detected individually but as a complex mixture. Advanced oxidative processes have been applied as an alternative or complement to conventional sewage treatment processes, aiming the degradation and removal of toxic pollutants. The objective of this study was to evaluate the toxicity removal of mixtures of pharmaceuticals subjected to electron beam treatment. The aqueous solutions of each pharmaceutical were diluted in ultra-pure water and prepared in three pharmaceuticals combinations: Propranolol + Fluoxetine + Sulfadiazine; Propranolol + Fluoxetine + Diclofenac; Acetylsalicylic acid + Fluoxetine + Metformin). Electron Beam Accelerator was applied for the irradiations and the absorbed doses were 2.5-5.0 kGy. Acute toxicity tests with Daphnia similis were performed to evaluate the toxicity, before and after irradiation.. The data analyzed showed toxicity removal efficiency around 80% for the mixture of Propranolol, Fluoxetine and Diclofenac; 75% for the mixture of Propranolol, Fluoxetine and Sulfadiazine; and 30% for the mixture of Acetylsalicylic acid, Fluoxetine and Metformin. According to the literature, this is a viable technology for the removal of toxicity from pharmaceuticals, and the results demonstrated the potential of electron beam irradiation in reducing the toxicity of pharmaceutical from different classes.1-11openAccessaquatic ecosystemscontaminationdrugselectron beamsenvironmental impactspollutantsradiation dose unitstoxicitywaste waterToxicity removal of pharmaceuticals mixtures through electron beam irradiationArtigo de periódico3B1010.15392/2319-0612.2022.1838https://orcid.org/0000-0002-9692-5539Sem PercentilSem Percentil CiteScore