ETCHEBEHERE, E.LIMA, M.PEREIRA, L.PAGNANO, R.BORTOLETTI, E.MENGATTI, J.BRUNETTO, S.Q.TAKAHASHI, M.BRUNETTO, E.OZELO, M.SANTOS, A.2022-02-042022-02-042020ETCHEBEHERE, E.; LIMA, M.; PEREIRA, L.; PAGNANO, R.; BORTOLETTI, E.; MENGATTI, J.; BRUNETTO, S.Q.; TAKAHASHI, M.; BRUNETTO, E.; OZELO, M.; SANTOS, A. Knee radiosynovectomy with Sm-153 hydroxyapatite compared to Y-90 hydroxyapatite: initial results of a prospective trial. <b>European Journal of Nuclear Medicine and Molecular Imaging</b>, v. 47, p. S628-S628, 2020. Supplement 1. DOI: <a href="https://dx.doi.org/10.1007/s00259-020-04988-4">10.1007/s00259-020-04988-4</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32698.1619-7070http://repositorio.ipen.br/handle/123456789/32698Aim/Introduction: Introduction: The most common clinical presentation in hemophilia patients consists of hemarthrosis. Various treatment strategies aim to control hemarthrosis to prevent secondary arthropathy, among them, radiosynovectomy with Y-90 hydroxyapatite (90YHA). A few studies have shown a lower efficiency of knee radiosynovectomy with Sm-153 hydroxyapatite (153Sm- HA) compared to 90Y-HA. Purpose: The purpose of this investigation was to assess the efficacy and safety of knee radiosynovectomy with 153Sm-HA compared to 90Y-HA. Materials and Methods: Forty patients were prospectively assigned to undergo knee radiosynovectomy with 153Sm- HA (19 patients) or with 90Y-HA (21 patients). The frequency of hemarthrosis episodes before and after treatment was compared. Results: The response to knee radiosynovectomy stratifying according to radiotracer showed that after 6 months the median response rate with 153Sm-HA was not significantly different from 90Y-HA (87.5% vs 80.9%; p = 0.576). However, after 12 months the median response rate of knee radiosynovectomy with 153Sm-HA was significantly better than with 90Y-HA (87.5% vs 50%; p = 0.037), respectively. The reduction of joint bleeding by at least 50%, after 12 months, was greater in the group of patients treated with 153Sm-HA compared to 90Y-HA (74% vs 52%), respectively. Conclusion: Knee radiosynovectomy with high doses of 153Sm-HA is safe, with an efficiency rate similar that is described in the literature by the 90Y-HA.S628-S628openAccessResumos em periódicos47Supplement 110.1007/s00259-020-04988-4https://orcid.org/0000-0003-0456-558996.6298.00