ROJAS CABRERA, W.I.DRUMOND, WALKER S.WANG, SHU H.MIYAGI, SUELYMARQUES, MARCIA M.LAGANA, DALVA C.BRESSIANI, ANA H.RIBEIRO, CHRISTIANE2014-11-172014-11-182015-04-022014-11-172014-11-182015-04-02ROJAS CABRERA, W.I.; DRUMOND, WALKER S.; WANG, SHU H.; MIYAGI, SUELY; MARQUES, MARCIA M.; LAGANA, DALVA C.; BRESSIANI, ANA H.; RIBEIRO, CHRISTIANE. Development of porous composite membrane of PLLA/PEG/HA for tissue engineering. In: INTERNATIONAL SYMPOSIUM ON MACROMOLECULES, 41st, July 16-21, 2006, Rio de Janeiro, RJ. <b>Proceedings...</b> Disponível em: http://repositorio.ipen.br/handle/123456789/15662.http://repositorio.ipen.br/handle/123456789/15662Composites membranes of poly(lactic acid)/poly(ethylene glycol)/hydroxyapatite (PLLA/PEG/HA), presenting uniform porosity distribution and characteristics appropriate for guided bone regeneration (GBR), were prepared in this work. The appropriate combination among polymer components (PLLA:PEG-1000, 2:3) and a biocompatible reinforcing ceramic filler (HA, 20 wt%), resulted in the development of composite devices presenting new mechanical and biological characteristics, ideal for bone matrix substitution, which allows cell growth. The membranes were prepared with a uniform porous (4 m) structure suitable for cells penetration, anchorage, differentiation and proliferation. The homogeneous porosity in membranes was achieved by self-organization during solvent evaporation process, due to phase-separated structure of the composites. The in vitro culture of osteoblasts on PLLA/PEG/HA membranes indicated good biocompatibility.openAccesstissuesskeletonbiological regenerationmembranespolyethylene glycolsapatitesporositycompatibilityreinforced materialsceramicsfillersconnective tissue cellsbiological materialsTexto completo de evento