MARIANO, KELLI C.F.NASCIMENTO, MONICA H.M. doQUEROBINO, SAMYR M.CAMPOS, ESTEFANIA V.R.OLIVEIRA, JHONES L. deYOKAICHIYA, FABIANOFRANCO, MARGARETH K.K.D.ALBERTO-SILVA, CARLOSPAULA, ENEIDA deLOMBELLO, CHRISTIANE B.LIMA, RENATA deFRACETO, LEONARDO F.ARAUJO, DANIELE R. de2020-04-072020-04-072020MARIANO, KELLI C.F.; NASCIMENTO, MONICA H.M. do; QUEROBINO, SAMYR M.; CAMPOS, ESTEFANIA V.R.; OLIVEIRA, JHONES L. de; YOKAICHIYA, FABIANO; FRANCO, MARGARETH K.K.D.; ALBERTO-SILVA, CARLOS; PAULA, ENEIDA de; LOMBELLO, CHRISTIANE B.; LIMA, RENATA de; FRACETO, LEONARDO F.; ARAUJO, DANIELE R. de. Influence of chitosan-tripolyphosphate nanoparticles on thermosensitive polymeric hydrogels: structural organization, drug release mechanisms and cytotoxicity. <b>International Journal of Polymeric Materials and Polymeric Biomaterials</b>, v. 69, n. 9, p. 592-603, 2020. DOI: <a href="https://dx.doi.org/10.1080/00914037.2019.1596909">10.1080/00914037.2019.1596909</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31100.0091-4037http://repositorio.ipen.br/handle/123456789/31100Chitosan-tripolyphosphate (CS-TPP) nanoparticles containing naproxen (NPX) were dispersed in poloxamer (PL) as unique (PL407) or binary (PL407-PL403) systems. Nanoparticles presented diameter of 250nm and zeta potential of 35mV with drug loading and encapsulation efficiency of 98.4 ± 0.3% and 36.9 ± 0.12%, respectively. NPX-CS-TPP shifted the sol-gel transition and micellization temperatures. PL407-PL403 systems presented G0 >G00 compared to PL407. SAXS patterns revealed transitions from lamellar to hexagonal phase organizations with low drug release rates, in the presence of CS-TPP nanoparticles. NPX-CS-TPP-PL407 induced lower cytotoxicity compared to PL407-PL403 in fibroblasts and osteoblasts, making them promising systems for intra-articular delivery.592-603openAccesspolysaccharideschitinnanoparticlesantipyreticsdrugsviabilityanimal cellssensitivitytemperature dependencehydrogelsArtigo de periódico96910.1080/00914037.2019.159690937.1667.00