LIMA, CAROLINE S.A. deVARCA, GUSTAVO H.C.COSTA, SIRLENE M. daFERRAZ, HUMBERTO G.SANTOS, ANA C. da S.LOPES, PATRICIA S.COSTA, SILGIA A. da2021-03-172021-03-172020LIMA, CAROLINE S.A. de; VARCA, GUSTAVO H.C.; COSTA, SIRLENE M. da; FERRAZ, HUMBERTO G.; SANTOS, ANA C. da S.; LOPES, PATRICIA S.; COSTA, SILGIA A. da. Development of natural polymeric microcapsules for antimicrobial drug delivery: triclosan loaded chitosan and alginate-based microcapsules. <b>Drug Development and Industrial Pharmacy</b>, v. 46, n. 9, p. 1477-1486, 2020. DOI: <a href="https://dx.doi.org/10.1080/03639045.2020.1809445">10.1080/03639045.2020.1809445</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/31916.0363-9045http://repositorio.ipen.br/handle/123456789/31916The goal of this work was the development of natural polymeric microcapsules for antimicrobial drug delivery – triclosan loaded alginate and chitosan-based microcapsules for potential coating applications in substrates such as textiles or plastics. Microcapsules containing 2.5% (w/w) or 3% (w/w) triclosan in both core and matrix were synthesized and evaluated by Fourier-transform infrared spectroscopy, scanning electron microscopy, confocal microscopy, differential scanning calorimetry, thermogravimetry, and antimicrobial activity. The microcapsules produced featured spherical and mostly irregularly-shaped surfaces composed by an alginate core in a chitosan outer matrix, as revealed by confocal microscopy, and antimicrobial activity against S. aureus and E. coli with inhibition halos up to 60 mm and 25 mm respectively, granted by a triclosan loading of 61.66%. The thermal analysis suggested that the polymers protected the active substance from temperature-induced degradation. In conclusion, these microcapsules may be applied toward antimicrobial functionalization of plastics, textiles and other materials.1477-1486openAccesspolysaccharidesoligosaccharidesantimicrobial agentsdrugsantisepticssodiumalginatespolymersDevelopment of natural polymeric microcapsules for antimicrobial drug deliveryArtigo de periódico94610.1080/03639045.2020.18094450000-0002-6545-237X44.6464.25