CABRAL, FERNANDA V.LIAN, CHENGPERSHEYEV, SAYDULLASMITH, TERRY K.RIBEIRO, MARTHA S.SAMUEL, IFOR D.W.2021-12-302021-12-302021CABRAL, FERNANDA V.; LIAN, CHENG; PERSHEYEV, SAYDULLA; SMITH, TERRY K.; RIBEIRO, MARTHA S.; SAMUEL, IFOR D.W. Organic light-emitting diodes as an innovative approach for treating cutaneous leishmaniasis. <b>Advanced Materials Technologies</b>, v. 6, n. 11, p. 1-9, 2021. DOI: <a href="https://dx.doi.org/10.1002/admt.202100395">10.1002/admt.202100395</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/32586.2365-709Xhttp://repositorio.ipen.br/handle/123456789/32586Antimicrobial photodynamic therapy (APDT) has been studied as a noninvasive therapy for treating cutaneous leishmaniasis to overcome challenges with current treatment, such as toxicity, resistance, and need for in-patient hospital treatment. Organic light-emitting diodes (OLEDs) have emerged as an attractive technology that can provide wearable light-emitting materials that are conformable to human skin. This makes OLEDs ideal candidates for APDT by light-bandages for ambulatory care. In this work, suitable OLEDs are successfully developed to match the absorbance of three photosensitizers: methylene blue, new methylene blue, and 1,9-dimethyl-methylene blue to inactivate two Leishmania species in vitro: Leishmania major and Leishmania amazonensis. Parasites are treated either by LED (20 mW cm−2) or OLED (6.5 mW cm−2) at increasing photosensitizer concentrations at a radiant exposure of 50 J cm−2. 1,9-Dimethyl-methylene blue is the most potent photosensitizer, killing both strains at nanomolar concentrations. The effect of different intensities from the OLEDs (0.7, 1.5, and 6.5 mW cm−2) are also explored and it is shown that effective killing of Leishmania occurs even at a very low intensity. These findings demonstrate the great potential of OLEDs as a new approach for ambulatory treatment of cutaneous leishmaniasis by APDT.1-9openAccessantibioticsantimicrobial agentslight emitting diodesorganic compoundsparasitesphotosensitivityArtigo de periódico11610.1002/admt.2021003950000-0002-4203-1134https://orcid.org/0000-0002-4203-113482.1793.00