HAMBLIN, MICHAEL R.SABINO, CAETANO P.SELLERA, FABIO P.NASCIMENTO, CRISTIANE L.RIBEIRO, MARTHA S.2018-03-062018-03-062016HAMBLIN, MICHAEL R.; SABINO, CAETANO P. Systemic effects. In: SELLERA, FABIO P. (ed.); NASCIMENTO, CRISTIANE L. (ed.); RIBEIRO, MARTHA S. (ed.). <b>Photodynamic therapy in veterinary medicine: from basics to clinical practice</b>. Gewerbestrasse, Switzerland: Springer, 2016. p. 73-91. DOI: <a href="https://dx.doi.org/10.1007/978-3-319-45007-0_6">10.1007/978-3-319-45007-0_6</a>. Disponível em: http://repositorio.ipen.br/handle/123456789/28661.http://repositorio.ipen.br/handle/123456789/28661Photodynamic therapy (PDT) is a clinically approved practice for treatment of cancer and infectious diseases. PDT involves systemic or topical administration of a photosensitizer (PS), followed by irradiation of the target area with light of a wavelength matching the absorption band of the PS. In the presence of oxygen, photochemical reactions trigger the production of reactive oxygen species and, consequently, cell death by oxidative stress. Besides causing direct cytotoxicity to tumor cells, PDT induces destruction of the tumor vasculature releasing pro-inflammatory cytokines. Current literature supports that PDT is able to affect both the innate and adaptive responses of the immune system. In addition, PDT-induced adaptive immunity may attack distant untreated tumor cells and lead to development of antitumor memory immunity, which can potentially avoid the cancer relapse. Conversely, pro-inflammatory activity of PDT can also collaborate to resolve local infections since more neutrophils are recruited to the infected region.73-91openAccessveterinary medicineanimalsphotodynamic therapytumor cellsneoplasmsimmunityCapítulo de livro10.1007/978-3-319-45007-0_6